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PMID:22647544
| Citation |
Halleskog, C, Dijksterhuis, JP, Kilander, MB, Becerril-Ortega, J, Villaescusa, JC, Lindgren, E, Arenas, E and Schulte, G (2012) Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation. J Neuroinflammation 9:111 |
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| Abstract |
WNT-5A signaling in the central nervous system is important for morphogenesis, neurogenesis and establishment of functional connectivity; the source of WNT-5A and its importance for cellular communication in the adult brain, however, are mainly unknown. We have previously investigated the inflammatory effects of WNT/β-catenin signaling in microglia in Alzheimer's disease. WNT-5A, however, generally recruits β-catenin-independent signaling. Thus, we aim here to characterize the role of WNT-5A and downstream signaling pathways for the inflammatory transformation of the brain's macrophages, the microglia. |
| Links |
PubMed PMC3458933 Online version:10.1186/1742-2094-9-111 |
| Keywords |
Animals; Animals, Newborn; Cells, Cultured; Heterotrimeric GTP-Binding Proteins/physiology; Inflammation Mediators/physiology; MAP Kinase Signaling System/physiology; Mice; Mice, Inbred C57BL; Microglia/pathology; Microglia/physiology; Wnt Proteins/physiology |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0070374: positive regulation of ERK1 and ERK2 cascade |
ECO:0000315: |
P |
Several inhibitors were used in Figure 5 which shows mapping of the WNT-5A-induced signaling pathway leading to ERK1/2 phosphorylation in primary microglia. |
complete | ||||
Notes
See also
References
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