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HUMAN:TRAIP
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TRAIP (synonyms: RNF206, TRIP) | |
| Protein Name(s) | E3 ubiquitin-protein ligase TRAIP
RING finger protein 206 TRAF-interacting protein | |
| External Links | ||
| UniProt | Q9BWF2 | |
| EMBL | U77845 AB451320 AB451449 BC000310 BC019283 | |
| CCDS | CCDS2806.1 | |
| RefSeq | NP_005870.2 | |
| UniGene | Hs.517972 | |
| ProteinModelPortal | Q9BWF2 | |
| SMR | Q9BWF2 | |
| BioGrid | 115581 | |
| IntAct | Q9BWF2 | |
| MINT | MINT-6781129 | |
| STRING | 9606.ENSP00000328203 | |
| PhosphoSite | Q9BWF2 | |
| DMDM | 30580637 | |
| MaxQB | Q9BWF2 | |
| PaxDb | Q9BWF2 | |
| PRIDE | Q9BWF2 | |
| DNASU | 10293 | |
| Ensembl | ENST00000331456 | |
| GeneID | 10293 | |
| KEGG | hsa:10293 | |
| UCSC | uc003cxs.1 | |
| CTD | 10293 | |
| GeneCards | GC03M049866 | |
| HGNC | HGNC:30764 | |
| HPA | HPA036261 | |
| MIM | 605958 | |
| neXtProt | NX_Q9BWF2 | |
| PharmGKB | PA142670705 | |
| eggNOG | NOG86944 | |
| GeneTree | ENSGT00390000007696 | |
| HOGENOM | HOG000054214 | |
| HOVERGEN | HBG059760 | |
| InParanoid | Q9BWF2 | |
| KO | K11985 | |
| OMA | KTMEQIE | |
| OrthoDB | EOG7HXCQV | |
| PhylomeDB | Q9BWF2 | |
| TreeFam | TF317309 | |
| SignaLink | Q9BWF2 | |
| UniPathway | UPA00143 | |
| ChiTaRS | TRAIP | |
| GeneWiki | TRAF_interacting_protein | |
| GenomeRNAi | 10293 | |
| NextBio | 35477924 | |
| PRO | PR:Q9BWF2 | |
| Proteomes | UP000005640 | |
| Bgee | Q9BWF2 | |
| CleanEx | HS_TRAIP | |
| ExpressionAtlas | Q9BWF2 | |
| Genevestigator | Q9BWF2 | |
| GO | GO:0005730 GO:0048471 GO:0016874 GO:0005057 GO:0004842 GO:0008270 GO:0006915 GO:0008283 GO:0007165 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR009053 IPR001841 IPR013083 | |
| Pfam | PF13639 | |
| SMART | SM00184 | |
| SUPFAM | SSF46579 | |
| PROSITE | PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0034504 |
protein localization to nucleus |
ECO:0000314 |
P |
figure 4A shows Trip colocalized into the nucleoli of the nucleus via immunoflorescence of MCF7 cells with overexpressed TRIP. |
complete | |||||
| GO:0034504 |
protein localization to nucleus |
ECO:0000315 |
P |
Trip knockdown with siRNA in figure 4B leads to reduced TRIP in the nucleoli of the nucleus in MCF7 cells showing that when trip is being expressed it is localized in the nucleoli of the nucleus. |
complete | |||||
|
Colocalizes with |
GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 4c and D shows when Sky-EGFP and TRIP were coexpressed then TRIP is colocalized along with SKY in the cytoplasm. |
complete | ||||
| GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000314 |
P |
Increasing amounts of TRIP results in decreased activation of NF-kB by the TNF mediated pathway. This is indicated in Figure 6 and Supplemental figure 3. |
complete | |||||
|
involved_in |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VIG6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VIG6 |
P |
Seeded From UniProt |
complete | ||
| GO:0005730 |
nucleolus |
ECO:0000314 |
C |
When the author epitope-tagged TRAIP at its C-terminus, it was found that TRAIP concentrated itself within the nucleolus of the cells (Figure 2a). |
complete | |||||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VIG6 |
P |
Seeded From UniProt |
complete | ||
|
Colocalizes with |
GO:0000794 |
condensed nuclear chromosome |
ECO:0000314 |
C |
Immunofluorescence revealed that TRAIP localized at the periphery of chromosomes (Figure 1). |
complete | ||||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VIG6 |
P |
Seeded From UniProt |
complete | ||
| GO:0010838 |
positive regulation of keratinocyte proliferation |
ECO:0000315 |
P |
BrdU incorporation was used to monitor cell proliferation and it was found that DNA synthesis in the TRAIP knockout cells were significantly reduced. Indicating that the knockout of TRAIP caused arrest in cell proliferation of the keratinocyte (Figure 1A). |
complete | |||||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VIG6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VIG6 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006915 |
apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Zhou, Q & Geahlen, RL (2009) The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Oncogene 28 1348-56 PubMed GONUTS page
- ↑ Feng, W et al. (2016) TRAIP regulates replication fork recovery and progression via PCNA. Cell Discov 2 16016 PubMed GONUTS page
- ↑ Chapard, C et al. (2014) TRAIP is a regulator of the spindle assembly checkpoint. J. Cell. Sci. 127 5149-56 PubMed GONUTS page
- ↑ Almeida, S et al. (2011) The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation. J. Invest. Dermatol. 131 349-57 PubMed GONUTS page
- ↑ 5.0 5.1 Lee, SY et al. (1997) TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. J. Exp. Med. 185 1275-85 PubMed GONUTS page
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