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HUMAN:MARH1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MARCH1 (synonyms: RNF171)
Protein Name(s) E3 ubiquitin-protein ligase MARCH1

Membrane-associated RING finger protein 1 Membrane-associated RING-CH protein I MARCH-I RING finger protein 171

External Links
UniProt Q8TCQ1
EMBL AK000675
AL713759
CH471056
CCDS CCDS3806.1
CCDS54814.1
RefSeq NP_001159845.1
NP_060393.1
XP_011530358.1
UniGene Hs.592804
Hs.608487
ProteinModelPortal Q8TCQ1
SMR Q8TCQ1
BioGrid 120348
STRING 9606.ENSP00000274056
iPTMnet Q8TCQ1
PhosphoSite Q8TCQ1
BioMuta MARCH1
DMDM 74762613
PaxDb Q8TCQ1
PRIDE Q8TCQ1
DNASU 55016
Ensembl ENST00000274056
ENST00000339875
ENST00000503008
GeneID 55016
KEGG hsa:55016
UCSC uc003iqr.3
CTD 55016
GeneCards MARCH1
HGNC HGNC:26077
HPA HPA014600
MIM 613331
neXtProt NX_Q8TCQ1
PharmGKB PA134986392
eggNOG KOG1609
COG5183
GeneTree ENSGT00730000110355
HOGENOM HOG000113483
HOVERGEN HBG081957
InParanoid Q8TCQ1
KO K10656
OMA ERRKICC
PhylomeDB Q8TCQ1
TreeFam TF319557
UniPathway UPA00143
ChiTaRS MARCH1
GenomeRNAi 55016
PRO PR:Q8TCQ1
Proteomes UP000005640
Bgee Q8TCQ1
CleanEx HS_MARCH1
ExpressionAtlas Q8TCQ1
Genevisible Q8TCQ1
GO GO:0030659
GO:0031901
GO:0005789
GO:0005768
GO:0016021
GO:0031902
GO:0005765
GO:0005764
GO:0005886
GO:0032588
GO:0016874
GO:0042287
GO:0061630
GO:0004842
GO:0008270
GO:0002495
GO:0006955
GO:0000209
Gene3D 3.30.40.10
InterPro IPR033275
IPR011016
IPR013083
PANTHER PTHR23012
Pfam PF12906
SMART SM00744
PROSITE PS51292

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042287

MHC protein binding

PMID:18389477[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0000209

protein polyubiquitination

PMID:27577745[2]

ECO:0000315

P

Figure 8C shows that wild-type MARCH1 polyubiquitinates INSR beta, while MARCH1 that is E3-ligase activity-defective does not. Figure 8D demonstrates that, in cells, knockdown of MARCH1 results in a decrease in INSR beta ubiquitination.

complete
CACAO 12111

part_of

GO:0032588

trans-Golgi network membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6NZQ8

C

Seeded From UniProt

complete

part_of

GO:0031902

late endosome membrane

PMID:19117940[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031901

early endosome membrane

PMID:19117940[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:18305173[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:18389477[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:19117940[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6NZQ8

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:14722266[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6NZQ8

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:14722266[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:18389477[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:19117940[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:18305173[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:14722266[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002495

antigen processing and presentation of peptide antigen via MHC class II

PMID:18389477[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:19117940[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

F

Seeded From UniProt

complete

part_of

GO:0032588

trans-Golgi network membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

part_of

GO:0031902

late endosome membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

part_of

GO:0031901

early endosome membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

F

Seeded From UniProt

complete

involved_in

GO:0002495

antigen processing and presentation of peptide antigen via MHC class II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011016

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0031901

early endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0093

C

Seeded From UniProt

complete

part_of

GO:0031902

late endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0151

C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0157

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Thibodeau, J et al. (2008) Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur. J. Immunol. 38 1225-30 PubMed GONUTS page
  2. ↑ Nagarajan, A et al. (2016) MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun 7 12639 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Lapaque, N et al. (2009) The HLA-DRalpha chain is modified by polyubiquitination. J. Biol. Chem. 284 7007-16 PubMed GONUTS page
  4. ↑ 4.0 4.1 De Gassart, A et al. (2008) MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc. Natl. Acad. Sci. U.S.A. 105 3491-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Bartee, E et al. (2004) Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J. Virol. 78 1109-20 PubMed GONUTS page
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