HUMAN:SH3R1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SH3RF1 (synonyms: KIAA1494, POSH, RNF142, SH3MD2)
Protein Name(s)	E3 ubiquitin-protein ligase SH3RF1 Plenty of SH3s Protein POSH RING finger protein 142 SH3 domain-containing RING finger protein 1 SH3 multiple domains protein 2
External Links
UniProt	Q7Z6J0
EMBL	BC033203 BC041023 BC053671 AK021429 AB040927
CCDS	CCDS34099.1
RefSeq	NP_065921.2
UniGene	Hs.301804
ProteinModelPortal	Q7Z6J0
SMR	Q7Z6J0
BioGrid	121673
IntAct	Q7Z6J0
MINT	MINT-2792302
STRING	9606.ENSP00000284637
PhosphoSite	Q7Z6J0
DMDM	205830834
MaxQB	Q7Z6J0
PaxDb	Q7Z6J0
PRIDE	Q7Z6J0
Ensembl	ENST00000284637
GeneID	57630
KEGG	hsa:57630
UCSC	uc003isa.1
CTD	57630
GeneCards	GC04M170015
HGNC	HGNC:17650
neXtProt	NX_Q7Z6J0
PharmGKB	PA134915904
eggNOG	NOG314495
GeneTree	ENSGT00760000119190
HOGENOM	HOG000045564
HOVERGEN	HBG069552
InParanoid	Q7Z6J0
KO	K12171
OMA	PCSSLGP
OrthoDB	EOG7HMS0X
PhylomeDB	Q7Z6J0
TreeFam	TF105571
SignaLink	Q7Z6J0
UniPathway	UPA00143
ChiTaRS	SH3RF1
GeneWiki	SH3RF1
GenomeRNAi	57630
NextBio	64333
PRO	PR:Q7Z6J0
Proteomes	UP000005640
Bgee	Q7Z6J0
CleanEx	HS_SH3RF1
ExpressionAtlas	Q7Z6J0
Genevestigator	Q7Z6J0
GO	GO:0005829 GO:0005794 GO:0030027 GO:0048471 GO:0016874 GO:0008270 GO:0043066 GO:0043154 GO:2001237 GO:0016567 GO:0046328
Gene3D	3.30.40.10
InterPro	IPR028502 IPR001452 IPR018957 IPR001841 IPR013083 IPR017907
PANTHER	PTHR10661:SF8
Pfam	PF14604 PF00097
PRINTS	PR00452
SMART	SM00184 SM00326
SUPFAM	SSF50044
PROSITE	PS50002 PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0005078	MAP-kinase scaffold activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q69ZI1	F		Seeded From UniProt	complete
involved_in	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q69ZI1	P		Seeded From UniProt	complete
involved_in	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q69ZI1	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q69ZI1	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q69ZI1	C		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q69ZI1	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:20696164	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:20696164	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21586138	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21586138	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21586138	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21586138	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028502	P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028502	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018957	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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References

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