HUMAN:SMUF1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SMURF1 (synonyms: KIAA1625)
Protein Name(s)	E3 ubiquitin-protein ligase SMURF1 hSMURF1 SMAD ubiquitination regulatory factor 1 SMAD-specific E3 ubiquitin-protein ligase 1
External Links
UniProt	Q9HCE7
EMBL	AB046845 AC004893 AF464850 AC073468 AC114500 CH236956 CH236956 CH471091 CH471091 BC136804 BC144414 BC152468 AF199364
CCDS	CCDS34689.1 CCDS34690.1
RefSeq	NP_001186776.1 NP_065162.1 NP_851994.1
UniGene	Hs.189329
PDB	2LAZ 2LB0 2LB1 2LTX 3PYC
PDBsum	2LAZ 2LB0 2LB1 2LTX 3PYC
ProteinModelPortal	Q9HCE7
SMR	Q9HCE7
BioGrid	121411
DIP	DIP-36709N
IntAct	Q9HCE7
MINT	MINT-102628
STRING	9606.ENSP00000354621
PhosphoSite	Q9HCE7
DMDM	17865625
MaxQB	Q9HCE7
PaxDb	Q9HCE7
PRIDE	Q9HCE7
Ensembl	ENST00000361125 ENST00000361368
GeneID	57154
KEGG	hsa:57154
UCSC	uc003upt.3 uc003upu.2
CTD	57154
GeneCards	GC07M098627
HGNC	HGNC:16807
HPA	CAB013009
MIM	605568
neXtProt	NX_Q9HCE7
PharmGKB	PA134987175
eggNOG	COG5021
GeneTree	ENSGT00760000118966
HOGENOM	HOG000208451
HOVERGEN	HBG004134
InParanoid	Q9HCE7
KO	K04678
OMA	TDNGRIY
OrthoDB	EOG77Q4W4
PhylomeDB	Q9HCE7
TreeFam	TF323658
Reactome	REACT_12034 REACT_120726 REACT_120727 REACT_172638 REACT_75842
SignaLink	Q9HCE7
UniPathway	UPA00143
ChiTaRS	SMURF1
EvolutionaryTrace	Q9HCE7
GeneWiki	SMURF1
GenomeRNAi	57154
NextBio	63133
PRO	PR:Q9HCE7
Proteomes	UP000005640
Bgee	Q9HCE7
CleanEx	HS_SMURF1
ExpressionAtlas	Q9HCE7
Genevestigator	Q9HCE7
GO	GO:0030424 GO:0005737 GO:0005829 GO:0070062 GO:0043025 GO:0005654 GO:0005634 GO:0005886 GO:0048185 GO:0070411 GO:0016874 GO:0070412 GO:0004842 GO:0030509 GO:0030154 GO:0007398 GO:0030514 GO:0030279 GO:0030512 GO:0043161 GO:0006611 GO:0034394 GO:0000209 GO:0016567 GO:0042787 GO:0032801 GO:0007179 GO:0030579
Gene3D	2.60.40.150
InterPro	IPR000008 IPR024928 IPR000569 IPR001202
Pfam	PF00168 PF00632 PF00397
PIRSF	PIRSF001569
SMART	SM00239 SM00119 SM00456
SUPFAM	SSF49562 SSF51045 SSF56204
PROSITE	PS50004 PS50237 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:21454619^[1]	ECO:0000315			P		Figure 4 shows how the mutation of this gene affects the regulation of the WFS1 protien	complete CACAO 7110
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:27214554^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:0061753	substrate localization to autophagosome	PMID:22020285^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_target_start_location:(GO:0005739)	Seeded From UniProt	complete
involved_in	GO:0061736	engulfment of target by autophagosome	PMID:22020285^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(GO:0005739)	Seeded From UniProt	complete
involved_in	GO:1903861	positive regulation of dendrite extension	PMID:23999003^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000148)	Seeded From UniProt	complete
involved_in	GO:0071211	protein targeting to vacuole involved in autophagy	PMID:22020285^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P03316)	Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	PMID:22020285^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9CUN6	C		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PMID:21454619^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:11278251^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99717	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:11278251^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:11278251^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:12151385^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:11278251^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43541	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:16720724^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:11278251^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	PMID:11278251^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:11278251^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:11278251^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	PMID:11278251^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11278251^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:12151385^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O15105)	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:11278251^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O15105)	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:19937093^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:10458166^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21572392^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:10458166^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21572392^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:19937093^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:10458166^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:19937093^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1933754 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 RGD:735047 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:O00308 UniProtKB:Q96PU5 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135002 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 PANTHER:PTN000135002 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1923038 MGI:MGI:97297 PANTHER:PTN000134256 SGD:S000000927 SGD:S000002865 TAIR:locus:2135630 UniProtKB:O00308 UniProtKB:P46934 UniProtKB:Q5BDP1 UniProtKB:Q8IYU2 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HCE7 WB:WBGene00007009	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 PANTHER:PTN000135002 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 PomBase:SPAC11G7.02 SGD:S000000927 UniProtKB:O15033 UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003557 FB:FBgn0259174 MGI:MGI:1202301 MGI:MGI:1914144 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c SGD:S000000927 TAIR:locus:2135630 UniProtKB:P46934 UniProtKB:Q7Z6Z7 UniProtKB:Q9HCE7 WB:WBGene00007009	C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9CUN6 ensembl:ENSMUSP00000082827	P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9CUN6 ensembl:ENSMUSP00000082827	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9CUN6 ensembl:ENSMUSP00000082827	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K612 ensembl:ENSRNOP00000073635	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K612 ensembl:ENSRNOP00000073635	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	F		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:22020285^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:22020285^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:10458166^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	PMID:10458166^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	Reactome:R-HSA-4608852	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	Reactome:R-HSA-2173791	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-2176396 Reactome:R-NUL-2169036 Reactome:R-NUL-2169016 Reactome:R-HSA-9009452 Reactome:R-HSA-5635865 Reactome:R-HSA-4608854 Reactome:R-HSA-4608852 Reactome:R-HSA-2160935 Reactome:R-HSA-2160932 Reactome:R-HSA-2160931 Reactome:R-HSA-201821 Reactome:R-HSA-201445	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-2169016 Reactome:R-NUL-2169012 Reactome:R-NUL-2169004 Reactome:R-HSA-8952419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Guo, X et al. (2011) The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum. J. Biol. Chem. 286 18037-47 PubMed GONUTS page
↑ Rothman, AM et al. (2016) MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension. J. Clin. Invest. 126 2495-508 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Orvedahl, A et al. (2011) Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 480 113-7 PubMed GONUTS page
↑ Yoo, JC et al. (2013) SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. J. Dermatol. Sci. 72 246-51 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Ebisawa, T et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 12477-80 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Suzuki, C et al. (2002) Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J. Biol. Chem. 277 39919-25 PubMed GONUTS page
↑ Yamaguchi, T et al. (2006) FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J. Mol. Endocrinol. 36 569-79 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Li, S et al. (2010) Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. Mol. Cell. Biochem. 338 11-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Zhu, H et al. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400 687-93 PubMed GONUTS page
↑ ^11.0 ^11.1 Cui, Y et al. (2011) SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J. 30 2675-89 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21454619-1] 1.0 ^1.1 Guo, X et al. (2011) The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum. J. Biol. Chem. 286 18037-47 PubMed GONUTS page

[PMID:27214554-2] Rothman, AM et al. (2016) MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension. J. Clin. Invest. 126 2495-508 PubMed GONUTS page

[PMID:22020285-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Orvedahl, A et al. (2011) Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 480 113-7 PubMed GONUTS page

[PMID:23999003-4] Yoo, JC et al. (2013) SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. J. Dermatol. Sci. 72 246-51 PubMed GONUTS page

[PMID:19056867-5] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:11278251-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Ebisawa, T et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 12477-80 PubMed GONUTS page

[PMID:12151385-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Suzuki, C et al. (2002) Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J. Biol. Chem. 277 39919-25 PubMed GONUTS page

[PMID:16720724-8] Yamaguchi, T et al. (2006) FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J. Mol. Endocrinol. 36 569-79 PubMed GONUTS page

[PMID:19937093-9] 9.0 ^9.1 ^9.2 Li, S et al. (2010) Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. Mol. Cell. Biochem. 338 11-7 PubMed GONUTS page

[PMID:10458166-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Zhu, H et al. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400 687-93 PubMed GONUTS page

[PMID:21572392-11] 11.0 ^11.1 Cui, Y et al. (2011) SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J. 30 2675-89 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:SMUF1

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