HUMAN:NEDD4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NEDD4 (synonyms: KIAA0093, NEDD4-1)
Protein Name(s)	E3 ubiquitin-protein ligase NEDD4 Cell proliferation-inducing gene 53 protein Neural precursor cell expressed developmentally down-regulated protein 4 NEDD-4
External Links
UniProt	P46934
EMBL	D42055 AK304394 AY550969 AL832063 AC009997 AC039057 CH471082 BC136605 BC144284 BC144285 BC152452 BC152562
CCDS	CCDS10156.1 CCDS45265.1 CCDS61643.1 CCDS61644.1
RefSeq	NP_001271267.1 NP_001271268.1 NP_001271269.1 NP_006145.2 NP_940682.2
UniGene	Hs.1565
PDB	2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H
PDBsum	2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H
ProteinModelPortal	P46934
SMR	P46934
BioGrid	110811
DIP	DIP-29815N
IntAct	P46934
MINT	MINT-86457
STRING	9606.ENSP00000345530
TCDB	8.A.30.1.2
PhosphoSite	P46934
BioMuta	NEDD4
DMDM	313104311
MaxQB	P46934
PaxDb	P46934
PRIDE	P46934
DNASU	4734
Ensembl	ENST00000338963 ENST00000435532 ENST00000506154 ENST00000508342
GeneID	4734
KEGG	hsa:4734
UCSC	uc002adi.3 uc002adj.3 uc002adl.3 uc010ugj.2
CTD	4734
GeneCards	GC15M056119
HGNC	HGNC:7727
HPA	CAB001991 HPA039883
MIM	602278
neXtProt	NX_P46934
PharmGKB	PA31533
eggNOG	COG5021
GeneTree	ENSGT00760000118966
HOVERGEN	HBG004134
InParanoid	P46934
KO	K10591
OMA	YSNENPQ
OrthoDB	EOG7RFTGT
PhylomeDB	P46934
TreeFam	TF323658
BRENDA	2.3.2.B9 6.3.2.19
Reactome	REACT_115828 REACT_115831 REACT_75842
SignaLink	P46934
UniPathway	UPA00143
ChiTaRS	NEDD4
EvolutionaryTrace	P46934
GeneWiki	NEDD4
GenomeRNAi	4734
NextBio	18250
PRO	PR:P46934
Proteomes	UP000005640
Bgee	P46934
CleanEx	HS_NEDD4
ExpressionAtlas	P46934
Genevisible	P46934
GO	GO:0016327 GO:0005938 GO:0000785 GO:0005737 GO:0005829 GO:0070062 GO:0005794 GO:0048471 GO:0005886 GO:0000151 GO:0031698 GO:0016874 GO:0050815 GO:0050816 GO:0070064 GO:0019904 GO:0070063 GO:0019871 GO:0043130 GO:0061630 GO:0002250 GO:0048514 GO:0034644 GO:0019221 GO:0044111 GO:0003197 GO:0042921 GO:0007041 GO:2000650 GO:0010766 GO:0010768 GO:0030948 GO:0007528 GO:0031175 GO:0003151 GO:0046824 GO:0014068 GO:0045732 GO:0050847 GO:0070534 GO:0006513 GO:0006622 GO:0016567 GO:0042787 GO:0032801 GO:0031623 GO:0048814 GO:0034765 GO:0042391 GO:1901016 GO:0050807 GO:0051592 GO:0042110 GO:0019089 GO:0043162
Gene3D	2.60.40.150
InterPro	IPR000008 IPR000569 IPR001202
Pfam	PF00632 PF00397
SMART	SM00119 SM00456
SUPFAM	SSF51045 SSF56204
PROSITE	PS50237 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0016567	protein ubiquitination	PMID:25631046^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	PMID:10642508^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:17996703^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901016	regulation of potassium ion transmembrane transporter activity	PMID:17289006^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	PMID:15126635^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070063	RNA polymerase binding	PMID:17996703^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P24928	F		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	PMID:8649367^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050816	phosphothreonine residue binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46935	F		Seeded From UniProt	complete
enables	GO:0050815	phosphoserine residue binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46935	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:9990509^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046824	positive regulation of nucleocytoplasmic transport	PMID:17218261^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	PMID:20086093^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:9990509^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	PMID:8649367^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:17996703^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:17218260^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:20086093^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:17289006^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	PMID:17289006^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:17996703^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:9990509^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	PMID:10642508^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019089	transmission of virus	PMID:15126635^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:17218260^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	PMID:17996703^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:9990509^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15126635^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46935	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12796489^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:20086093^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q07912)	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:17996703^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:17996703^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46935	C		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62940	P		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	PMID:11342538^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15038	F		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46935	P		Seeded From UniProt	complete
involved_in	GO:0044111	development involved in symbiotic interaction	PMID:15126635^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	PMID:18544533^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031698	beta-2 adrenergic receptor binding	PMID:18544533^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:18544533^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P46935	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:12907594^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q969W9	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:18305167^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010766	negative regulation of sodium ion transport	PMID:10642508^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007041	lysosomal transport	PMID:18544533^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006622	protein targeting to lysosome	PMID:17116753^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16118794^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:16118794^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000882924 UniProtKB:P46934 UniProtKB:Q96PU5	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1933754 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000135098	P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000882924 RGD:3157	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 RGD:735047 UniProtKB:P46934	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000135098	C		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:O00308 UniProtKB:Q96PU5 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1923038 MGI:MGI:97297 PANTHER:PTN000134256 SGD:S000000927 SGD:S000002865 TAIR:locus:2135630 UniProtKB:O00308 UniProtKB:P46934 UniProtKB:Q5BDP1 UniProtKB:Q8IYU2 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HCE7 WB:WBGene00007009	P		Seeded From UniProt	complete
involved_in	GO:0007528	neuromuscular junction development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000135098	P		Seeded From UniProt	complete
involved_in	GO:0006622	protein targeting to lysosome	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000882924 UniProtKB:P46934 UniProtKB:Q96PU5	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 PomBase:SPAC11G7.02 SGD:S000000927 UniProtKB:O15033 UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003557 FB:FBgn0259174 MGI:MGI:1202301 MGI:MGI:1914144 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c SGD:S000000927 TAIR:locus:2135630 UniProtKB:P46934 UniProtKB:Q7Z6Z7 UniProtKB:Q9HCE7 WB:WBGene00007009	C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:14973438^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:26280536^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	C		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	F		Seeded From UniProt	complete
enables	GO:0050816	phosphothreonine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	F		Seeded From UniProt	complete
enables	GO:0050815	phosphoserine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	F		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	C		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	F		Seeded From UniProt	complete
involved_in	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	C		Seeded From UniProt	complete
involved_in	GO:0010766	negative regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0007528	neuromuscular junction development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	C		Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46935 ensembl:ENSMUSP00000034740	P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	PMID:25809873^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:9405440^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016327	apicolateral plasma membrane	PMID:9405440^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:9405440^[23] Reactome:R-HSA-6807134 Reactome:R-HSA-1977296 Reactome:R-HSA-1973956 Reactome:R-HSA-1169399	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:26263374^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		The organism is homo sapiens and the protein is NEDD4. Figure 1C shows that overexpression of NEDD4 is sufficient to show ubiquitination of IFITM3 on a Western blot. Figure 7E shows that inhibition of lysosomal proteases increased IFITM3 levels meaning that NEDD4 is involved in ubiquitin-dependent catabolic process	complete CACAO 13028
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Low, LH et al. (2015) Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J. Biol. Chem. 290 7141-50 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Farr, TJ et al. (2000) Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochem. J. 345 Pt 3 503-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Anindya, R et al. (2007) Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol. Cell 28 386-97 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Jespersen, T et al. (2007) The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc. Res. 74 64-74 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Blot, V et al. (2004) Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. J. Cell. Sci. 117 2357-67 PubMed GONUTS page
↑ ^7.0 ^7.1 Imhof, MO & McDonnell, DP (1996) Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol. Cell. Biol. 16 2594-605 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Anan, T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3 751-63 PubMed GONUTS page
↑ Trotman, LC et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128 141-56 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Lin, Q et al. (2010) HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol. Cell. Biol. 30 1541-54 PubMed GONUTS page
↑ ^11.0 ^11.1 Wang, X et al. (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128 129-39 PubMed GONUTS page
↑ Cristillo, AD et al. (2003) Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. J. Biol. Chem. 278 34587-97 PubMed GONUTS page
↑ Hamilton, MH et al. (2001) Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J. Biol. Chem. 276 26324-31 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Shenoy, SK et al. (2008) Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J. Biol. Chem. 283 22166-76 PubMed GONUTS page
↑ Xu, LL et al. (2003) PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. Cancer Res. 63 4299-304 PubMed GONUTS page
↑ Okumura, A et al. (2008) ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc. Natl. Acad. Sci. U.S.A. 105 3974-9 PubMed GONUTS page
↑ Pak, Y et al. (2006) Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J. Cell Biol. 175 631-45 PubMed GONUTS page
↑ ^18.0 ^18.1 Shirk, AJ et al. (2005) SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J. Neurosci. Res. 82 43-50 PubMed GONUTS page
↑ ^19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 ^19.11 ^19.12 ^19.13 ^19.14 ^19.15 ^19.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Heissmeyer, V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 255-65 PubMed GONUTS page
↑ Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page
↑ Li, Y et al. (2015) Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy. Cell Prolif. 48 338-47 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Plant, PJ et al. (1997) The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization. J. Biol. Chem. 272 32329-36 PubMed GONUTS page
↑ Chesarino, NM et al. (2015) E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog. 11 e1005095 PubMed GONUTS page

[PMID:25631046-1] Low, LH et al. (2015) Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J. Biol. Chem. 290 7141-50 PubMed GONUTS page

[PMID:10642508-2] 2.0 ^2.1 ^2.2 Farr, TJ et al. (2000) Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochem. J. 345 Pt 3 503-9 PubMed GONUTS page

[PMID:17996703-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Anindya, R et al. (2007) Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol. Cell 28 386-97 PubMed GONUTS page

[PMID:23533145-4] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:17289006-5] 5.0 ^5.1 ^5.2 Jespersen, T et al. (2007) The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc. Res. 74 64-74 PubMed GONUTS page

[PMID:15126635-6] 6.0 ^6.1 ^6.2 ^6.3 Blot, V et al. (2004) Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. J. Cell. Sci. 117 2357-67 PubMed GONUTS page

[PMID:8649367-7] 7.0 ^7.1 Imhof, MO & McDonnell, DP (1996) Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol. Cell. Biol. 16 2594-605 PubMed GONUTS page

[PMID:9990509-8] 8.0 ^8.1 ^8.2 ^8.3 Anan, T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3 751-63 PubMed GONUTS page

[PMID:17218261-9] Trotman, LC et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128 141-56 PubMed GONUTS page

[PMID:20086093-10] 10.0 ^10.1 ^10.2 Lin, Q et al. (2010) HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol. Cell. Biol. 30 1541-54 PubMed GONUTS page

[PMID:17218260-11] 11.0 ^11.1 Wang, X et al. (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128 129-39 PubMed GONUTS page

[PMID:12796489-12] Cristillo, AD et al. (2003) Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. J. Biol. Chem. 278 34587-97 PubMed GONUTS page

[PMID:11342538-13] Hamilton, MH et al. (2001) Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J. Biol. Chem. 276 26324-31 PubMed GONUTS page

[PMID:18544533-14] 14.0 ^14.1 ^14.2 ^14.3 Shenoy, SK et al. (2008) Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J. Biol. Chem. 283 22166-76 PubMed GONUTS page

[PMID:12907594-15] Xu, LL et al. (2003) PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. Cancer Res. 63 4299-304 PubMed GONUTS page

[PMID:18305167-16] Okumura, A et al. (2008) ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc. Natl. Acad. Sci. U.S.A. 105 3974-9 PubMed GONUTS page

[PMID:17116753-17] Pak, Y et al. (2006) Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J. Cell Biol. 175 631-45 PubMed GONUTS page

[PMID:16118794-18] 18.0 ^18.1 Shirk, AJ et al. (2005) SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J. Neurosci. Res. 82 43-50 PubMed GONUTS page

[PMID:21873635-19] 19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 ^19.11 ^19.12 ^19.13 ^19.14 ^19.15 ^19.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14973438-20] Heissmeyer, V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 255-65 PubMed GONUTS page

[PMID:26280536-21] Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page

[PMID:25809873-22] Li, Y et al. (2015) Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy. Cell Prolif. 48 338-47 PubMed GONUTS page

[PMID:9405440-23] 23.0 ^23.1 ^23.2 Plant, PJ et al. (1997) The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization. J. Biol. Chem. 272 32329-36 PubMed GONUTS page

[PMID:26263374-24] Chesarino, NM et al. (2015) E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog. 11 e1005095 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

HUMAN:NEDD4

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

l

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools