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PMID:9990509
| Citation |
Anan, T, Nagata, Y, Koga, H, Honda, Y, Yabuki, N, Miyamoto, C, Kuwano, A, Matsuda, I, Endo, F, Saya, H and Nakao, M (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3:751-63 |
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| Abstract |
Nedd4 is a ubiquitin-protein ligase containing a calcium/lipid-binding domain, multiple WW domains and a C-terminal Hect domain, which is required for both the ubiquitin transfer and the association with E2 ubiquitin-conjugating enzymes. Nedd4 has been reported to be involved in the selective ubiquitination of some regulatory proteins in transcription and membrane transport. |
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| Keywords |
Cell Differentiation; Cell Nucleus/enzymology; Chromosome Mapping; Chromosomes, Human, Pair 15; Down-Regulation; Humans; Ligases/metabolism; Neurons/cytology; Neurons/enzymology; Protein Binding; Sequence Deletion; Subcellular Fractions/enzymology; Tumor Cells, Cultured; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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