MOUSE:TRI63

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Trim63 (synonyms: Murf1, Rf1)
Protein Name(s)	E3 ubiquitin-protein ligase TRIM63 Muscle-specific RING finger protein 1 MuRF-1 MuRF1 Muscle RING finger protein 1 RING-type E3 ubiquitin transferase TRIM63 (ECO:0000305) Tripartite motif-containing protein 63
External Links
UniProt	Q38HM4
EMBL	DQ229108 AK052911
UniGene	Mm.331961
ProteinModelPortal	Q38HM4
SMR	Q38HM4
STRING	10090.ENSMUSP00000101501
iPTMnet	Q38HM4
PhosphoSitePlus	Q38HM4
PaxDb	Q38HM4
PRIDE	Q38HM4
UCSC	uc008ves.1
MGI	MGI:2447992
eggNOG	ENOG410ITEN ENOG4110918
HOVERGEN	HBG071242
InParanoid	Q38HM4
UniPathway	UPA00143
PRO	PR:Q38HM4
Proteomes	UP000000589
CleanEx	MM_TRIM63
GO	GO:0043292 GO:0005737 GO:0031430 GO:0005634 GO:0030018 GO:0031432 GO:0061630 GO:0008270 GO:0071549 GO:0006936 GO:0043161 GO:0010468 GO:0014894 GO:0014878
CDD	cd00021
Gene3D	3.30.40.10
InterPro	IPR017903 IPR027370 IPR000315 IPR001841 IPR013083 IPR017907
Pfam	PF00643 PF13445
SMART	SM00336 SM00184
PROSITE	PS51262 PS50119 PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006513	protein monoubiquitination	PMID:26862156^[1]	ECO:0000314			P		The organism is Mus Musculus and the protein is referred to as MuRF1 ( muscle-specific ubiquitin ligase muscle ring finger-1 ) in the article but is actually called TRI63. Figure 5C showss that MuRF1 is able mono- ubiquitinate TRalpha (thyroid receptor protein).	complete CACAO 13027
involved_in	GO:0014894	response to denervation involved in regulation of muscle adaptation	PMID:21465538^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91Z63	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071549	cellular response to dexamethasone stimulus	PMID:23752591^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:15601779^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:98783)	Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	PMID:15601779^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q91Z63	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:15601779^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031432	titin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969Q1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619964	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619964	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:19850579^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006936	muscle contraction	PMID:15601779^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q91Z63	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969Q1	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619964	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000315	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9625772 Reactome:R-MMU-9625730	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0314	C		Seeded From UniProt	complete
part_of	GO:0031430	M band	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0315	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wadosky, KM et al. (2016) MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo. J. Mol. Endocrinol. 56 273-90 PubMed GONUTS page
↑ Macpherson, PC et al. (2011) Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. J. Cell. Biochem. 112 2149-59 PubMed GONUTS page
↑ Proserpio, V et al. (2013) The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 27 1299-312 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Kedar, V et al. (2004) Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc. Natl. Acad. Sci. U.S.A. 101 18135-40 PubMed GONUTS page
↑ Mearini, G et al. (2010) Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovasc. Res. 85 357-66 PubMed GONUTS page

[PMID:26862156-1] Wadosky, KM et al. (2016) MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo. J. Mol. Endocrinol. 56 273-90 PubMed GONUTS page

[PMID:21465538-2] Macpherson, PC et al. (2011) Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. J. Cell. Biochem. 112 2149-59 PubMed GONUTS page

[PMID:23752591-3] Proserpio, V et al. (2013) The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 27 1299-312 PubMed GONUTS page

[PMID:15601779-4] 4.0 ^4.1 ^4.2 ^4.3 Kedar, V et al. (2004) Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc. Natl. Acad. Sci. U.S.A. 101 18135-40 PubMed GONUTS page

[PMID:19850579-5] Mearini, G et al. (2010) Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovasc. Res. 85 357-66 PubMed GONUTS page

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MOUSE:TRI63

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