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HUMAN:WWP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WWP1
Protein Name(s) NEDD4-like E3 ubiquitin-protein ligase WWP1

Atrophin-1-interacting protein 5 AIP5 TGIF-interacting ubiquitin ligase 1 Tiul1 WW domain-containing protein 1

External Links
UniProt Q9H0M0
EMBL AL136739
AY043361
AY345857
AC083845
AC103817
BC015380
BC036065
U96113
CCDS CCDS6242.1
RefSeq NP_008944.1
XP_005250817.1
UniGene Hs.655189
PDB 1ND7
2OP7
PDBsum 1ND7
2OP7
ProteinModelPortal Q9H0M0
SMR Q9H0M0
BioGrid 116243
IntAct Q9H0M0
MINT MINT-199541
STRING 9606.ENSP00000265428
PhosphoSite Q9H0M0
DMDM 32171908
MaxQB Q9H0M0
PaxDb Q9H0M0
PRIDE Q9H0M0
DNASU 11059
Ensembl ENST00000265428
ENST00000517970
GeneID 11059
KEGG hsa:11059
UCSC uc003ydt.3
CTD 11059
GeneCards GC08P087424
HGNC HGNC:17004
HPA HPA023180
MIM 602307
neXtProt NX_Q9H0M0
PharmGKB PA134960138
eggNOG COG5021
GeneTree ENSGT00760000118966
HOGENOM HOG000208453
HOVERGEN HBG004134
InParanoid Q9H0M0
KO K05633
OMA MLSAEND
OrthoDB EOG7RFTGT
PhylomeDB Q9H0M0
TreeFam TF323658
Reactome REACT_115828
REACT_160189
REACT_75842
SignaLink Q9H0M0
UniPathway UPA00143
ChiTaRS WWP1
EvolutionaryTrace Q9H0M0
GeneWiki WWP1
GenomeRNAi 11059
NextBio 42019
PRO PR:Q9H0M0
Proteomes UP000005640
Bgee Q9H0M0
CleanEx HS_WWP1
ExpressionAtlas Q9H0M0
Genevestigator Q9H0M0
GO GO:0005737
GO:0005829
GO:0070062
GO:0005634
GO:0005886
GO:0000151
GO:0016874
GO:0004842
GO:0007417
GO:0034220
GO:0045892
GO:0043161
GO:0016567
GO:0042787
GO:0007165
GO:0055085
GO:0046718
Gene3D 2.60.40.150
InterPro IPR000008
IPR024928
IPR000569
IPR001202
Pfam PF00168
PF00632
PF00397
PIRSF PIRSF001569
SMART SM00239
SM00119
SM00456
SUPFAM SSF49562
SSF51045
SSF56204
PROSITE PS50004
PS50237
PS01159
PS50020

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:2000060

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

PMID:21487105[1]

ECO:0000314

P

Figure 5G shows the protein that is the gene product of human WWP1's involvement in the degradation of the KLF5 protein. When the WWP1 gene was knocked down using siRNA, levels of the KLF5 protein increased dramatically relative to a wild-type control in a Western Blot assay, provided that estrogen was provided in the assay.

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BZZ3

P

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

PMID:9647693[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9169421[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

PMID:9169421[4]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259174
MGI:MGI:1861728
MGI:MGI:1914144
MGI:MGI:1933754
MGI:MGI:97297
PANTHER:PTN000134256
PomBase:SPAC11G7.02
PomBase:SPAC1805.15c
UniProtKB:P46934
UniProtKB:Q96J02
UniProtKB:Q9HCE7

F

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202301
MGI:MGI:97297
PANTHER:PTN000134745
RGD:735047
UniProtKB:P46934

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861728
MGI:MGI:1914144
PANTHER:PTN001679348
UniProtKB:O00308

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861728
MGI:MGI:1914144
PANTHER:PTN000134745
SGD:S000000927
UniProtKB:O00308
UniProtKB:Q96PU5
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259174
MGI:MGI:1861728
MGI:MGI:1914144
MGI:MGI:1923038
MGI:MGI:97297
PANTHER:PTN000134256
SGD:S000000927
SGD:S000002865
TAIR:locus:2135630
UniProtKB:O00308
UniProtKB:P46934
UniProtKB:Q5BDP1
UniProtKB:Q8IYU2
UniProtKB:Q96J02
UniProtKB:Q96PU5
UniProtKB:Q9HCE7
WB:WBGene00007009

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202301
PANTHER:PTN001679348
UniProtKB:Q96J02

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029006
MGI:MGI:1202301
MGI:MGI:97297
PANTHER:PTN000134745
PomBase:SPAC11G7.02
SGD:S000000927
UniProtKB:O15033
UniProtKB:P46934
UniProtKB:Q96J02
UniProtKB:Q96PU5
UniProtKB:Q9HAU4
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003557
FB:FBgn0259174
MGI:MGI:1202301
MGI:MGI:1914144
MGI:MGI:97297
PANTHER:PTN000134256
PomBase:SPAC11G7.02
PomBase:SPAC1805.15c
SGD:S000000927
TAIR:locus:2135630
UniProtKB:P46934
UniProtKB:Q7Z6Z7
UniProtKB:Q9HCE7
WB:WBGene00007009

C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202301
PANTHER:PTN000134745
SGD:S000000927
UniProtKB:Q9HCE7

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BZZ3
ensembl:ENSMUSP00000103881

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BZZ3
ensembl:ENSMUSP00000103881

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BZZ3
ensembl:ENSMUSP00000103881

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BZZ3
ensembl:ENSMUSP00000103881

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BZZ3
ensembl:ENSMUSP00000103881

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000569
InterPro:IPR035983

F

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024928

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024928

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:9647693[3]
PMID:9169421[4]
Reactome:R-HSA-2682349

ECO:0000304

author statement supported by traceable reference used in manual assertion



F

Seeded From UniProt

complete

involved_in

GO:0046718

viral entry into host cell

PMID:12450395[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:12535537[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

Reactome:R-HSA-983712

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-2682349
Reactome:R-HSA-1253300
Reactome:R-HSA-1253282

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Nakajima, Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4 ra22 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ 3.0 3.1 Wood, JD et al. (1998) Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol. Cell. Neurosci. 11 149-60 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Pirozzi, G et al. (1997) Identification of novel human WW domain-containing proteins by cloning of ligand targets. J. Biol. Chem. 272 14611-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Galinier, R et al. (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry 41 14299-305 PubMed GONUTS page
  7. ↑ Verdecia, MA et al. (2003) Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol. Cell 11 249-59 PubMed GONUTS page
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