MOUSE:NEDD4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nedd4 (synonyms: Kiaa0093, Nedd-4, Nedd4-1, Nedd4a)
Protein Name(s)	E3 ubiquitin-protein ligase NEDD4 Neural precursor cell expressed developmentally down-regulated protein 4 NEDD-4
External Links
UniProt	P46935
EMBL	D85414 U96635 AK088620 AK088767 AK122203 AK133838
CCDS	CCDS72275.1
RefSeq	NP_035020.2
UniGene	Mm.279923
PDB	3M7F
PDBsum	3M7F
ProteinModelPortal	P46935
SMR	P46935
BioGrid	201723
DIP	DIP-32323N
IntAct	P46935
MINT	MINT-90132
PhosphoSite	P46935
MaxQB	P46935
PaxDb	P46935
PRIDE	P46935
Ensembl	ENSMUST00000034740
GeneID	17999
KEGG	mmu:17999
UCSC	uc009qqe.1
CTD	4734
MGI	MGI:97297
eggNOG	COG5021
GeneTree	ENSGT00760000118966
HOGENOM	HOG000208451
HOVERGEN	HBG004134
InParanoid	P46935
KO	K10591
OMA	HEFRRTQ
OrthoDB	EOG7RFTGT
PhylomeDB	P46935
TreeFam	TF323658
Reactome	REACT_198533 REACT_199100 REACT_199115
UniPathway	UPA00143
ChiTaRS	Nedd4
NextBio	292995
PRO	PR:P46935
Proteomes	UP000000589
Bgee	P46935
ExpressionAtlas	P46935
Genevestigator	P46935
GO	GO:0005938 GO:0000785 GO:0005737 GO:0005829 GO:0005794 GO:0016020 GO:0005634 GO:0048471 GO:0005886 GO:0000151 GO:0016874 GO:0050815 GO:0050816 GO:0070064 GO:0019871 GO:0061630 GO:0002250 GO:0048514 GO:0044111 GO:0003197 GO:0042921 GO:0010766 GO:0000122 GO:0010768 GO:0030948 GO:0007528 GO:0031175 GO:0003151 GO:0046824 GO:0014068 GO:0045732 GO:0050847 GO:0070534 GO:0006513 GO:0006622 GO:0016567 GO:0042787 GO:0032801 GO:0031623 GO:0048814 GO:0042391 GO:1901016 GO:0050807 GO:0042110 GO:0019089 GO:0043162
Gene3D	2.60.40.150
InterPro	IPR000008 IPR024928 IPR000569 IPR001202
Pfam	PF00168 PF00632 PF00397
PIRSF	PIRSF001569
SMART	SM00239 SM00119 SM00456
SUPFAM	SSF49562 SSF51045 SSF56204
PROSITE	PS50004 PS50237 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0043197	dendritic spine	PMID:25505317^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608) exists_during:(GO:0035235)	Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:25505317^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P23818)	Seeded From UniProt	complete
enables	GO:0050816	phosphothreonine residue binding	PMID:10037602^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050815	phosphoserine residue binding	PMID:10037602^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62940	P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:20159449^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	PMID:15060076^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	PMID:25505317^[1]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	PMID:25505317^[1]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:25505317^[1]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:25505317^[1]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000882924 UniProtKB:P46934 UniProtKB:Q96PU5	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1933754 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000135098	P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000882924 RGD:3157	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 RGD:735047 UniProtKB:P46934	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000135098	C		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:O00308 UniProtKB:Q96PU5 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1923038 MGI:MGI:97297 PANTHER:PTN000134256 SGD:S000000927 SGD:S000002865 TAIR:locus:2135630 UniProtKB:O00308 UniProtKB:P46934 UniProtKB:Q5BDP1 UniProtKB:Q8IYU2 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HCE7 WB:WBGene00007009	P		Seeded From UniProt	complete
involved_in	GO:0007528	neuromuscular junction development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000135098	P		Seeded From UniProt	complete
involved_in	GO:0006622	protein targeting to lysosome	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135098 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000882924 UniProtKB:P46934 UniProtKB:Q96PU5	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 PomBase:SPAC11G7.02 SGD:S000000927 UniProtKB:O15033 UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003557 FB:FBgn0259174 MGI:MGI:1202301 MGI:MGI:1914144 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c SGD:S000000927 TAIR:locus:2135630 UniProtKB:P46934 UniProtKB:Q7Z6Z7 UniProtKB:Q9HCE7 WB:WBGene00007009	C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	P		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	PMID:9305852^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97764 UniProtKB:Q16621	F		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	PMID:11748237^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8R0W6	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:9182527^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:11717310^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:2136825)\|has_direct_input:(MGI:MGI:2684414)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050807	regulation of synapse organization	PMID:19345204^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:20026598^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98737	P	has_participant:(EMAPA:16240)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:20026598^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3799317	P	has_participant:(EMAPA:16240)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	PMID:11748237^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46934	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042110	T cell activation	PMID:18931680^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3829272	P		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	PMID:10212229^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000068)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	PMID:9182527^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	PMID:26280536^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46934	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:14973438^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000545)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010766	negative regulation of sodium ion transport	PMID:10212229^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000068)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007528	neuromuscular junction development	PMID:19345204^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006513	protein monoubiquitination	PMID:21920314^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(MGI:MGI:1888986)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:18931680^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3829272	P	occurs_in:(CL:0000084) has_direct_input:(MGI:MGI:2146430)	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:9182527^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19794060^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14973438^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000545)	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3157	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003197	endocardial cushion development	PMID:20026598^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98737	P	results_in_development_of:(EMAPA:16696)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003197	endocardial cushion development	PMID:20026598^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3799317	P	results_in_development_of:(EMAPA:16696)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	PMID:20026598^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98737	P	has_participant:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	PMID:20026598^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3799317	P	has_participant:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002250	adaptive immune response	PMID:18931680^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3829272	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:11042109^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QYK7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20026598^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3799317	P	has_regulation_target:(MGI:MGI:98737)	Seeded From UniProt	complete
involved_in	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:1901016	regulation of potassium ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	F		Seeded From UniProt	complete
enables	GO:0070063	RNA polymerase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	F		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	C		Seeded From UniProt	complete
involved_in	GO:0046824	positive regulation of nucleocytoplasmic transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0044111	development involved in symbiotic interaction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	F		Seeded From UniProt	complete
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0032801	receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
enables	GO:0031698	beta-2 adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	F		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	F		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	F		Seeded From UniProt	complete
involved_in	GO:0019089	transmission of virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0010766	negative regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0007041	lysosomal transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0006622	protein targeting to lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46934 ensembl:ENSP00000424827	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Scudder, SL et al. (2014) Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8. J. Neurosci. 34 16637-49 PubMed GONUTS page
↑ ^2.0 ^2.1 Lu, PJ et al. (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283 1325-8 PubMed GONUTS page
↑ Kawabe, H et al. (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 65 358-72 PubMed GONUTS page
↑ Murdaca, J et al. (2004) Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J. Biol. Chem. 279 26754-61 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Gavva, NR et al. (1997) Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J. Biol. Chem. 272 24105-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Harvey, KF et al. (2002) N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J. Biol. Chem. 277 9307-17 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hatakeyama, S et al. (1997) Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J. Biol. Chem. 272 15085-92 PubMed GONUTS page
↑ Murillas, R et al. (2002) Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. J. Biol. Chem. 277 2897-907 PubMed GONUTS page
↑ ^10.0 ^10.1 Liu, Y et al. (2009) Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev. Biol. 330 153-66 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Fouladkou, F et al. (2010) The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J. Biol. Chem. 285 6770-80 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Yang, B et al. (2008) Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat. Immunol. 9 1356-63 PubMed GONUTS page
↑ ^13.0 ^13.1 Harvey, KF et al. (1999) All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. J. Biol. Chem. 274 12525-30 PubMed GONUTS page
↑ Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page
↑ ^15.0 ^15.1 Heissmeyer, V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 255-65 PubMed GONUTS page
↑ Van Campenhout, CA et al. (2011) Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev. Cell 21 479-91 PubMed GONUTS page
↑ Aitken, JF et al. (2010) Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice. Diabetes 59 161-71 PubMed GONUTS page
↑ Jolliffe, CN et al. (2000) Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem. J. 351 Pt 3 557-65 PubMed GONUTS page

[PMID:25505317-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Scudder, SL et al. (2014) Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8. J. Neurosci. 34 16637-49 PubMed GONUTS page

[PMID:10037602-2] 2.0 ^2.1 Lu, PJ et al. (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283 1325-8 PubMed GONUTS page

[PMID:20159449-3] Kawabe, H et al. (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 65 358-72 PubMed GONUTS page

[PMID:15060076-4] Murdaca, J et al. (2004) Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J. Biol. Chem. 279 26754-61 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9305852-6] Gavva, NR et al. (1997) Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J. Biol. Chem. 272 24105-8 PubMed GONUTS page

[PMID:11748237-7] 7.0 ^7.1 Harvey, KF et al. (2002) N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J. Biol. Chem. 277 9307-17 PubMed GONUTS page

[PMID:9182527-8] 8.0 ^8.1 ^8.2 Hatakeyama, S et al. (1997) Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J. Biol. Chem. 272 15085-92 PubMed GONUTS page

[PMID:11717310-9] Murillas, R et al. (2002) Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. J. Biol. Chem. 277 2897-907 PubMed GONUTS page

[PMID:19345204-10] 10.0 ^10.1 Liu, Y et al. (2009) Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev. Biol. 330 153-66 PubMed GONUTS page

[PMID:20026598-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Fouladkou, F et al. (2010) The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J. Biol. Chem. 285 6770-80 PubMed GONUTS page

[PMID:18931680-12] 12.0 ^12.1 ^12.2 Yang, B et al. (2008) Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat. Immunol. 9 1356-63 PubMed GONUTS page

[PMID:10212229-13] 13.0 ^13.1 Harvey, KF et al. (1999) All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. J. Biol. Chem. 274 12525-30 PubMed GONUTS page

[PMID:26280536-14] Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page

[PMID:14973438-15] 15.0 ^15.1 Heissmeyer, V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5 255-65 PubMed GONUTS page

[PMID:21920314-16] Van Campenhout, CA et al. (2011) Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev. Cell 21 479-91 PubMed GONUTS page

[PMID:19794060-17] Aitken, JF et al. (2010) Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice. Diabetes 59 161-71 PubMed GONUTS page

[PMID:11042109-18] Jolliffe, CN et al. (2000) Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem. J. 351 Pt 3 557-65 PubMed GONUTS page

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