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PMID:9305852
| Citation |
Gavva, NR, Gavva, R, Ermekova, K, Sudol, M and Shen, CJ (1997) Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J. Biol. Chem. 272:24105-8 |
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| Abstract |
NF-E2 is an erythroid-specific transcription factor required for expression of several erythroid-specific genes. By Far-Western blotting and yeast two-hybrid assay, we demonstrate that p45, the large subunit of NF-E2, is capable of binding to a specific set of WW domain-containing proteins, including the ubiquitin ligase hRPF1. This binding is mediated through the interaction between the WW domains and a PY motif located within the amino-terminal region of p45. Interestingly, the carboxyl-terminal domain of mammalian RNA polymerase II binds a similar set of WW domains to which p45 interacts with. We discuss the data in terms of possible new pathways through which the processes of transcriptional regulation by NF-E2 could be regulated in erythroid and megakaryote cells. |
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| Keywords |
Amino Acid Sequence; Bone Marrow/metabolism; DNA-Binding Proteins/metabolism; Erythroid-Specific DNA-Binding Factors; Molecular Sequence Data; NF-E2 Transcription Factor; NF-E2 Transcription Factor, p45 Subunit; Protein Binding; RNA Polymerase II/chemistry; RNA Polymerase II/metabolism; Saccharomyces cerevisiae/genetics; Sequence Homology, Amino Acid; Transcription Factors/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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