ARATH:COP1

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	COP1
Protein Name(s)	E3 ubiquitin-protein ligase COP1 Constitutive photomorphogenesis protein 1
External Links
UniProt	P43254
EMBL	L24437 AC003033 CP002685 BT025337 AJ000535 AJ000536
PIR	T01112
RefSeq	NP_180854.1
UniGene	At.298
ProteinModelPortal	P43254
SMR	P43254
BioGrid	3204
DIP	DIP-32850N
IntAct	P43254
MINT	MINT-189205
STRING	3702.AT2G32950.1-P
PaxDb	P43254
PRIDE	P43254
EnsemblPlants	AT2G32950.1
GeneID	817857
KEGG	ath:AT2G32950
GeneFarm	2849
TAIR	AT2G32950
eggNOG	COG2319
HOGENOM	HOG000006123
InParanoid	P43254
KO	K10143
OMA	IAEIRHG
PhylomeDB	P43254
Reactome	REACT_244054
UniPathway	UPA00143
PRO	PR:P43254
Proteomes	UP000006548
ExpressionAtlas	P43254
Genevestigator	P43254
GO	GO:0080008 GO:0005737 GO:0016604 GO:0000152 GO:0005634 GO:0042802 GO:0016874 GO:0004842 GO:0008270 GO:0046283 GO:0006281 GO:0009649 GO:0009640 GO:0048573 GO:0009585 GO:0010119 GO:0009641 GO:0009647
Gene3D	2.130.10.10 3.30.40.10
InterPro	IPR015943 IPR001680 IPR019775 IPR017986 IPR001841 IPR013083 IPR017907
Pfam	PF00400
SMART	SM00184 SM00320
SUPFAM	SSF50978
PROSITE	PS00678 PS50082 PS50294 PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005634	nucleus	PMID:26474641^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:26474641^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	PMID:18223036^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	AGI_LocusCode:AT4G15900	C	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:29087315^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048573	photoperiodism, flowering	PMID:18388858^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046283	anthocyanin-containing compound metabolic process	PMID:17217468^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:23647163^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010119	regulation of stomatal movement	PMID:16093319^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	AGI_LocusCode:AT3G45780 AGI_LocusCode:AT5G58140	P	Seeded From UniProt	complete
involved_in	GO:0010119	regulation of stomatal movement	PMID:16093319^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009649	entrainment of circadian clock	PMID:21395889^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009641	shade avoidance	PMID:8205001^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009640	photomorphogenesis	PMID:20061554^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	AGI_LocusCode:At5g46210	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:18434413^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19061637^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16829591^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11080276^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:15705947^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9755158^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P43254	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18812498^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P43254	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17551013^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P43254	F	Seeded From UniProt	complete
involved_in	GO:0009647	skotomorphogenesis	PMID:11080276^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000152	nuclear ubiquitin ligase complex	PMID:10839542^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0009585	red, far-red light phototransduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0607	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0010017	red or far-red light signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0607	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Srivastava, AK et al. (2015) Short Hypocotyl in White Light1 Interacts with Elongated Hypocotyl5 (HY5) and Constitutive Photomorphogenic1 (COP1) and Promotes COP1-Mediated Degradation of HY5 during Arabidopsis Seedling Development. Plant Physiol. 169 2922-34 PubMed GONUTS page
↑ Lee, JH et al. (2008) Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Plant Cell 20 152-67 PubMed GONUTS page
↑ Lian, N et al. (2017) COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating hypocotyl elongation. Proc. Natl. Acad. Sci. U.S.A. 114 12321-12326 PubMed GONUTS page
↑ Jang, S et al. (2008) Arabidopsis COP1 shapes the temporal pattern of CO accumulation conferring a photoperiodic flowering response. EMBO J. 27 1277-88 PubMed GONUTS page
↑ Vandenbussche, F et al. (2007) HY5 is a point of convergence between cryptochrome and cytokinin signalling pathways in Arabidopsis thaliana. Plant J. 49 428-41 PubMed GONUTS page
↑ Pacín, M et al. (2013) COP1 re-accumulates in the nucleus under shade. Plant J. 75 631-41 PubMed GONUTS page
↑ ^7.0 ^7.1 Mao, J et al. (2005) From The Cover: A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening. Proc. Natl. Acad. Sci. U.S.A. 102 12270-5 PubMed GONUTS page
↑ Fehér, B et al. (2011) Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana. Plant J. 67 37-48 PubMed GONUTS page
↑ McNellis, TW et al. (1994) Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains. Plant Cell 6 487-500 PubMed GONUTS page
↑ Chen, H et al. (2010) Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell 22 108-23 PubMed GONUTS page
↑ Dohmann, EM et al. (2008) The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development 135 2013-22 PubMed GONUTS page
↑ Yu, JW et al. (2008) COP1 and ELF3 control circadian function and photoperiodic flowering by regulating GI stability. Mol. Cell 32 617-30 PubMed GONUTS page
↑ Oravecz, A et al. (2006) CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis. Plant Cell 18 1975-90 PubMed GONUTS page
↑ ^14.0 ^14.1 Stacey, MG et al. (2000) Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta. Plant Physiol. 124 979-90 PubMed GONUTS page
↑ Yang, J et al. (2005) Light regulates COP1-mediated degradation of HFR1, a transcription factor essential for light signaling in Arabidopsis. Plant Cell 17 804-21 PubMed GONUTS page
↑ Torii, KU et al. (1998) Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development. EMBO J. 17 5577-87 PubMed GONUTS page
↑ Zhu, D et al. (2008) Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development. Plant Cell 20 2307-23 PubMed GONUTS page
↑ Xu, X et al. (2007) Imaging protein interactions with bioluminescence resonance energy transfer (BRET) in plant and mammalian cells and tissues. Proc. Natl. Acad. Sci. U.S.A. 104 10264-9 PubMed GONUTS page
↑ Osterlund, MT et al. (2000) Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature 405 462-6 PubMed GONUTS page

[PMID:26474641-1] 1.0 ^1.1 Srivastava, AK et al. (2015) Short Hypocotyl in White Light1 Interacts with Elongated Hypocotyl5 (HY5) and Constitutive Photomorphogenic1 (COP1) and Promotes COP1-Mediated Degradation of HY5 during Arabidopsis Seedling Development. Plant Physiol. 169 2922-34 PubMed GONUTS page

[PMID:18223036-2] Lee, JH et al. (2008) Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Plant Cell 20 152-67 PubMed GONUTS page

[PMID:29087315-3] Lian, N et al. (2017) COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating hypocotyl elongation. Proc. Natl. Acad. Sci. U.S.A. 114 12321-12326 PubMed GONUTS page

[PMID:18388858-4] Jang, S et al. (2008) Arabidopsis COP1 shapes the temporal pattern of CO accumulation conferring a photoperiodic flowering response. EMBO J. 27 1277-88 PubMed GONUTS page

[PMID:17217468-5] Vandenbussche, F et al. (2007) HY5 is a point of convergence between cryptochrome and cytokinin signalling pathways in Arabidopsis thaliana. Plant J. 49 428-41 PubMed GONUTS page

[PMID:23647163-6] Pacín, M et al. (2013) COP1 re-accumulates in the nucleus under shade. Plant J. 75 631-41 PubMed GONUTS page

[PMID:16093319-7] 7.0 ^7.1 Mao, J et al. (2005) From The Cover: A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening. Proc. Natl. Acad. Sci. U.S.A. 102 12270-5 PubMed GONUTS page

[PMID:21395889-8] Fehér, B et al. (2011) Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana. Plant J. 67 37-48 PubMed GONUTS page

[PMID:8205001-9] McNellis, TW et al. (1994) Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains. Plant Cell 6 487-500 PubMed GONUTS page

[PMID:20061554-10] Chen, H et al. (2010) Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell 22 108-23 PubMed GONUTS page

[PMID:18434413-11] Dohmann, EM et al. (2008) The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development 135 2013-22 PubMed GONUTS page

[PMID:19061637-12] Yu, JW et al. (2008) COP1 and ELF3 control circadian function and photoperiodic flowering by regulating GI stability. Mol. Cell 32 617-30 PubMed GONUTS page

[PMID:16829591-13] Oravecz, A et al. (2006) CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis. Plant Cell 18 1975-90 PubMed GONUTS page

[PMID:11080276-14] 14.0 ^14.1 Stacey, MG et al. (2000) Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta. Plant Physiol. 124 979-90 PubMed GONUTS page

[PMID:15705947-15] Yang, J et al. (2005) Light regulates COP1-mediated degradation of HFR1, a transcription factor essential for light signaling in Arabidopsis. Plant Cell 17 804-21 PubMed GONUTS page

[PMID:9755158-16] Torii, KU et al. (1998) Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development. EMBO J. 17 5577-87 PubMed GONUTS page

[PMID:18812498-17] Zhu, D et al. (2008) Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development. Plant Cell 20 2307-23 PubMed GONUTS page

[PMID:17551013-18] Xu, X et al. (2007) Imaging protein interactions with bioluminescence resonance energy transfer (BRET) in plant and mammalian cells and tissues. Proc. Natl. Acad. Sci. U.S.A. 104 10264-9 PubMed GONUTS page

[PMID:10839542-19] Osterlund, MT et al. (2000) Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature 405 462-6 PubMed GONUTS page

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ARATH:COP1

Contents

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