MOUSE:RNF12

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rlim (synonyms: Rnf12)
Protein Name(s)	E3 ubiquitin-protein ligase RLIM LIM domain-interacting RING finger protein RING finger LIM domain-binding protein R-LIM RING finger protein 12
External Links
UniProt	Q9WTV7
EMBL	AF069992 AK013207 AK029295 AL805911 CH466564 CH466564 BC012960
CCDS	CCDS30331.1
RefSeq	NP_035406.3 XP_006527980.1 XP_006527981.1 XP_006527982.1 XP_006527983.1 XP_006527984.1
UniGene	Mm.427762 Mm.490660
ProteinModelPortal	Q9WTV7
SMR	Q9WTV7
BioGrid	202918
DIP	DIP-46445N
STRING	10090.ENSMUSP00000070662
PhosphoSite	Q9WTV7
MaxQB	Q9WTV7
PRIDE	Q9WTV7
Ensembl	ENSMUST00000070705 ENSMUST00000121153
GeneID	19820
KEGG	mmu:19820
UCSC	uc009tzz.1
CTD	51132
MGI	MGI:1342291
eggNOG	COG5540
GeneTree	ENSGT00730000110459
HOGENOM	HOG000273881
InParanoid	Q9WTV7
KO	K16271
OMA	DNLAMRN
OrthoDB	EOG7Z69CK
PhylomeDB	Q9WTV7
TreeFam	TF325756
UniPathway	UPA00143
NextBio	297281
PRO	PR:Q9WTV7
Proteomes	UP000000589
Bgee	Q9WTV7
CleanEx	MM_RNF12
Genevestigator	Q9WTV7
GO	GO:0005737 GO:0005634 GO:0016874 GO:0061630 GO:0004842 GO:0008270 GO:0043433 GO:0000122 GO:0016567 GO:0060816 GO:0006351 GO:0006511
Gene3D	3.30.40.10
InterPro	IPR001841 IPR013083
Pfam	PF13639
SMART	SM00184
PROSITE	PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060816	random inactivation of X chromosome	PMID:19945382^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:11882901^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:11882901^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19945382^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:11882901^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900095	regulation of dosage compensation by inactivation of X chromosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342291 PANTHER:PTN000366022	P		Seeded From UniProt	complete
involved_in	GO:0060816	random inactivation of X chromosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342291 PANTHER:PTN000366022 UniProtKB:Q9NVW2	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000366017 UniProtKB:Q9NVW2	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900095	regulation of dosage compensation by inactivation of X chromosome	PMID:24613346^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:16204183^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:104572)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060816	random inactivation of X chromosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NVW2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:10431247^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894670	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NVW2	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NVW2	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10431247^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10431247^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107157 MGI:MGI:1097691	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10431247^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102673 MGI:MGI:97588	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10431247^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102673 MGI:MGI:894670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10431247^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102673 MGI:MGI:107374 MGI:MGI:894670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10431247^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102673	P		Seeded From UniProt	complete
involved_in	GO:0060816	random inactivation of X chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NVW2 ensembl:ENSP00000328059	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NVW2 ensembl:ENSP00000328059	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NVW2 ensembl:ENSP00000328059	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Jonkers, I et al. (2009) RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation. Cell 139 999-1011 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ostendorff, HP et al. (2002) Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature 416 99-103 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Barakat, TS et al. (2014) The trans-activator RNF12 and cis-acting elements effectuate X chromosome inactivation independent of X-pairing. Mol. Cell 53 965-78 PubMed GONUTS page
↑ Tursun, B et al. (2005) The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 19 2307-19 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Bach, I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 22 394-9 PubMed GONUTS page

[PMID:19945382-1] 1.0 ^1.1 Jonkers, I et al. (2009) RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation. Cell 139 999-1011 PubMed GONUTS page

[PMID:11882901-2] 2.0 ^2.1 ^2.2 Ostendorff, HP et al. (2002) Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature 416 99-103 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24613346-4] Barakat, TS et al. (2014) The trans-activator RNF12 and cis-acting elements effectuate X chromosome inactivation independent of X-pairing. Mol. Cell 53 965-78 PubMed GONUTS page

[PMID:16204183-5] Tursun, B et al. (2005) The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 19 2307-19 PubMed GONUTS page

[PMID:10431247-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Bach, I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 22 394-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

MOUSE:RNF12

Contents

Annotations

Notes

References

c

e

g

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools