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MOUSE:AREL1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Arel1 (synonyms: Kiaa0317) | |
| Protein Name(s) | Apoptosis-resistant E3 ubiquitin protein ligase 1
Apoptosis-resistant HECT-type E3 ubiquitin transferase 1 | |
| External Links | ||
| UniProt | Q8CHG5 | |
| EMBL | AB093230 AK077015 BC049900 BC060658 | |
| CCDS | CCDS26051.1 | |
| RefSeq | NP_835166.3 XP_006516252.1 XP_006516253.1 | |
| UniGene | Mm.24446 | |
| ProteinModelPortal | Q8CHG5 | |
| SMR | Q8CHG5 | |
| STRING | 10090.ENSMUSP00000048780 | |
| iPTMnet | Q8CHG5 | |
| PhosphoSitePlus | Q8CHG5 | |
| MaxQB | Q8CHG5 | |
| PaxDb | Q8CHG5 | |
| PRIDE | Q8CHG5 | |
| Ensembl | ENSMUST00000043169 | |
| GeneID | 68497 | |
| KEGG | mmu:68497 | |
| UCSC | uc007ofy.1 | |
| CTD | 9870 | |
| MGI | MGI:1915747 | |
| eggNOG | KOG0939 COG5021 | |
| GeneTree | ENSGT00850000132302 | |
| HOGENOM | HOG000008177 | |
| HOVERGEN | HBG052181 | |
| InParanoid | Q8CHG5 | |
| OMA | KPRKVLC | |
| OrthoDB | EOG091G05DB | |
| PhylomeDB | Q8CHG5 | |
| TreeFam | TF323417 | |
| UniPathway | UPA00143 | |
| PRO | PR:Q8CHG5 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000042350 | |
| CleanEx | MM_1110018G07RIK | |
| ExpressionAtlas | Q8CHG5 | |
| Genevisible | Q8CHG5 | |
| GO | GO:0005737 GO:0005829 GO:0061630 GO:0004842 GO:0006915 GO:0043066 GO:0042787 | |
| CDD | cd00078 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR017868 IPR000569 IPR035983 IPR013783 IPR014756 | |
| Pfam | PF00630 PF00632 | |
| SMART | SM00119 | |
| SUPFAM | SSF56204 SSF81296 | |
| PROSITE | PS50194 PS50237 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
the organism is Mus Musculus and the protein is AREL1(Apoptosis-resistant E3 ubiquitin protein ligase 1). Figure 4A shows that AREL1 can ubiquitinate multiple proteins including ARTS, HtrA2, and SMAC. and the rest of Figure 4 shows that the ubiquitination is enough to cause degradation of ARTS, HtrA2, and SMAC |
complete | ||||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0259174 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1202301 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861728 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000134954 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0259174 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0029006 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003557 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1202301 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15033 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15033 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15033 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15033 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kim, JB et al. (2013) Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J. Biol. Chem. 288 12014-21 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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