MOUSE:FBXW7

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fbxw7 (synonyms: Fbw7, Fbwd6, Fbxw6)
Protein Name(s)	F-box/WD repeat-containing protein 7 F-box and WD-40 domain-containing protein 7 F-box protein FBW7 F-box protein Fbxw6 F-box-WD40 repeat protein 6 SEL-10
External Links
UniProt	Q8VBV4
EMBL	AF391202 AF391193 AF391194 AF391195 AF391196 AF391197 AF391198 AF391199 AF391200 AF391201 AF391192 AF427101 BC131648 AK032174
CCDS	CCDS17440.1
RefSeq	NP_536353.2
UniGene	Mm.196475
ProteinModelPortal	Q8VBV4
SMR	Q8VBV4
BioGrid	206088
IntAct	Q8VBV4
MINT	MINT-4609106
PRIDE	Q8VBV4
Ensembl	ENSMUST00000029727
GeneID	50754
KEGG	mmu:50754
UCSC	uc008pql.2
CTD	55294
MGI	MGI:1354695
eggNOG	COG2319
GeneTree	ENSGT00760000119106
HOGENOM	HOG000236264
HOVERGEN	HBG051596
InParanoid	Q8VBV4
KO	K10260
OMA	DHVITCM
OrthoDB	EOG7VX8VF
PhylomeDB	Q8VBV4
Reactome	REACT_196464 REACT_196589 REACT_196591 REACT_196604 REACT_199115 REACT_244970
NextBio	307631
PRO	PR:Q8VBV4
Proteomes	UP000000589
Bgee	Q8VBV4
ExpressionAtlas	Q8VBV4
Genevestigator	Q8VBV4
GO	GO:0005737 GO:0005783 GO:0005794 GO:0016021 GO:0005739 GO:0005634 GO:1990452 GO:0048471 GO:0019005 GO:0030332 GO:0042802 GO:0030674 GO:0003700 GO:0031625 GO:0097027 GO:0006974 GO:0034644 GO:0030324 GO:0032876 GO:0007219 GO:0045741 GO:0070374 GO:1903378 GO:1901800 GO:0031398 GO:2000060 GO:0051443 GO:0050821 GO:0016567 GO:0006355 GO:0031146 GO:0007062 GO:0001570
Gene3D	2.130.10.10
InterPro	IPR001810 IPR020472 IPR015943 IPR001680 IPR019775 IPR017986
Pfam	PF12937 PF00400
PRINTS	PR00320
SMART	SM00256 SM00320
SUPFAM	SSF50978 SSF81383
PROSITE	PS50181 PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	PMID:23507969^[1]	ECO:0000315			P		Figure 1E to 1H	complete CACAO 7046
involved_in	GO:2001205	negative regulation of osteoclast development	PMID:29149593^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:27238018^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PMID:27238018^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:21953459^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050816	phosphothreonine residue binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
involved_in	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	PMID:23507969^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
enables	GO:0097027	ubiquitin-protein transferase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0-1	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0-1	P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0032876	negative regulation of DNA endoreduplication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0007062	sister chromatid cohesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:23858059^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23858059^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000530) part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1901800	positive regulation of proteasomal protein catabolic process	PMID:23858059^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000530) occurs_in:(UBERON:0000955) has_regulation_target:(UniProtKB:P97287)	Seeded From UniProt	complete
involved_in	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	PMID:23858059^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20208556^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20208556^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000457424 PomBase:SPBC887.04c SGD:S000001696 UniProtKB:Q969H0	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000457424 SGD:S000001696	F		Seeded From UniProt	complete
involved_in	GO:0010992	ubiquitin recycling	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000457424 SGD:S000001696	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104810 PANTHER:PTN000457424 PomBase:SPBC887.04c UniProtKB:Q969H0 UniProtKB:Q9Y263	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104810 MGI:MGI:1354695 PANTHER:PTN000457424 PomBase:SPBC887.04c UniProtKB:Q969H0 UniProtKB:Q9Y263	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001205	negative regulation of osteoclast development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
part_of	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903955	positive regulation of protein targeting to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903146	regulation of autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	PMID:18625840^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901800	positive regulation of proteasomal protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
enables	GO:0097027	ubiquitin-protein transferase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
enables	GO:0050816	phosphothreonine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042752	regulation of circadian rhythm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034644	cellular response to UV	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032876	negative regulation of DNA endoreduplication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	PMID:18625840^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:21503901^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5007620	P		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	PMID:12354302^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:11425854^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007062	sister chromatid cohesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11735228^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:11735228^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:18625840^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q969H0	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18625840^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|part_of	GO:0005634	nucleus	PMID:11735228^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:21503901^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097027	ubiquitin-protein transferase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
enables	GO:0050816	phosphothreonine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	F		Seeded From UniProt	complete
involved_in	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	F		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:0032876	negative regulation of DNA endoreduplication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	F		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	F		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	F		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:0007062	sister chromatid cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	C		Seeded From UniProt	complete
involved_in	GO:2001205	negative regulation of osteoclast development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
part_of	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	C		Seeded From UniProt	complete
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
involved_in	GO:1901800	positive regulation of proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969H0 ensembl:ENSP00000474725	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	Reactome:R-MMU-9008715	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9008717 Reactome:R-MMU-9008715 Reactome:R-MMU-9008677	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11425854^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11425854^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wang, R et al. (2013) FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Res. 23 803-19 PubMed GONUTS page
↑ Fukushima, H et al. (2017) NOTCH2 Hajdu-Cheney Mutations Escape SCF-Dependent Proteolysis to Promote Osteoporosis. Mol. Cell 68 645-658.e5 PubMed GONUTS page
↑ ^3.0 ^3.1 Zhao, X et al. (2016) Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell 165 1644-1657 PubMed GONUTS page
↑ Biswas, M et al. (2011) The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J. Biol. Chem. 286 39282-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page
↑ ^6.0 ^6.1 Rocher-Ros, V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29 2950-61 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Bonetti, P et al. (2008) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J. Cell Biol. 182 19-26 PubMed GONUTS page
↑ ^9.0 ^9.1 Davis, H et al. (2011) FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J. Pathol. 224 180-9 PubMed GONUTS page
↑ Li, J et al. (2002) SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. J. Neurochem. 82 1540-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Gupta-Rossi, N et al. (2001) Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J. Biol. Chem. 276 34371-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Maruyama, S et al. (2001) Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Genomics 78 214-22 PubMed GONUTS page

[PMID:23507969-1] 1.0 ^1.1 Wang, R et al. (2013) FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Res. 23 803-19 PubMed GONUTS page

[PMID:29149593-2] Fukushima, H et al. (2017) NOTCH2 Hajdu-Cheney Mutations Escape SCF-Dependent Proteolysis to Promote Osteoporosis. Mol. Cell 68 645-658.e5 PubMed GONUTS page

[PMID:27238018-3] 3.0 ^3.1 Zhao, X et al. (2016) Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell 165 1644-1657 PubMed GONUTS page

[PMID:21953459-4] Biswas, M et al. (2011) The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J. Biol. Chem. 286 39282-9 PubMed GONUTS page

[PMID:23858059-5] 5.0 ^5.1 ^5.2 ^5.3 Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page

[PMID:20208556-6] 6.0 ^6.1 Rocher-Ros, V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29 2950-61 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18625840-8] 8.0 ^8.1 ^8.2 ^8.3 Bonetti, P et al. (2008) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J. Cell Biol. 182 19-26 PubMed GONUTS page

[PMID:21503901-9] 9.0 ^9.1 Davis, H et al. (2011) FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J. Pathol. 224 180-9 PubMed GONUTS page

[PMID:12354302-10] Li, J et al. (2002) SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. J. Neurochem. 82 1540-8 PubMed GONUTS page

[PMID:11425854-11] 11.0 ^11.1 ^11.2 Gupta-Rossi, N et al. (2001) Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J. Biol. Chem. 276 34371-8 PubMed GONUTS page

[PMID:11735228-12] 12.0 ^12.1 ^12.2 Maruyama, S et al. (2001) Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Genomics 78 214-22 PubMed GONUTS page

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