name: ubiquitin-like protein ligase activity
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def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
synonym: "small conjugating protein ligase activity" EXACT [GOC:dph]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
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