Category:GO:0061662 ! ISG15 ligase activity

name: ISG15 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0042296 ! ISG15 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity

AmiGO <GOterm>GO:0061662</GOterm>
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