MOUSE:NED4L

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nedd4l (synonyms: Kiaa0439, Nedd4b)
Protein Name(s)	E3 ubiquitin-protein ligase NEDD4-like NEDD4.2 Nedd4-2
External Links
UniProt	Q8CFI0
EMBL	AF277232 BC039746 BC071210 AK042621
CCDS	CCDS29305.1
UniGene	Mm.98668
PDB	1WR3 1WR4 1WR7
PDBsum	1WR3 1WR4 1WR7
ProteinModelPortal	Q8CFI0
SMR	Q8CFI0
DIP	DIP-48843N
IntAct	Q8CFI0
MINT	MINT-5097552
TCDB	8.A.30.1.1
PhosphoSite	Q8CFI0
MaxQB	Q8CFI0
PaxDb	Q8CFI0
PRIDE	Q8CFI0
MGI	MGI:1933754
eggNOG	COG5021
HOGENOM	HOG000208451
HOVERGEN	HBG004134
InParanoid	Q8CFI0
PhylomeDB	Q8CFI0
UniPathway	UPA00143
ChiTaRS	Nedd4l
EvolutionaryTrace	Q8CFI0
PRO	PR:Q8CFI0
Proteomes	UP000000589
Genevestigator	Q8CFI0
GO	GO:0005737 GO:0005634 GO:0016874 GO:0019871 GO:0061630 GO:0004842 GO:0010766 GO:0003085 GO:2001259 GO:0010765 GO:0042787 GO:2000810 GO:0009651 GO:0043162
Gene3D	2.60.40.150
InterPro	IPR000008 IPR024928 IPR000569 IPR001202
Pfam	PF00168 PF00632 PF00397
PIRSF	PIRSF001569
PRINTS	PR00360
SMART	SM00239 SM00119 SM00456
SUPFAM	SSF49562 SSF51045 SSF56204
PROSITE	PS50004 PS50237 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
involved_in	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000882924 UniProtKB:P46934 UniProtKB:Q96PU5	P		Seeded From UniProt	complete
involved_in	GO:1901380	negative regulation of potassium ion transmembrane transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135072 UniProtKB:Q96PU5	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1933754 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000882924 RGD:3157	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 RGD:735047 UniProtKB:P46934	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:O00308 UniProtKB:Q96PU5 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1923038 MGI:MGI:97297 PANTHER:PTN000134256 SGD:S000000927 SGD:S000002865 TAIR:locus:2135630 UniProtKB:O00308 UniProtKB:P46934 UniProtKB:Q5BDP1 UniProtKB:Q8IYU2 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HCE7 WB:WBGene00007009	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97297 PANTHER:PTN000882924 UniProtKB:P46934 UniProtKB:Q96PU5	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 PomBase:SPAC11G7.02 SGD:S000000927 UniProtKB:O15033 UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003557 FB:FBgn0259174 MGI:MGI:1202301 MGI:MGI:1914144 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c SGD:S000000927 TAIR:locus:2135630 UniProtKB:P46934 UniProtKB:Q7Z6Z7 UniProtKB:Q9HCE7 WB:WBGene00007009	C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:Q9HCE7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001288	positive regulation of caveolin-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001259	positive regulation of cation channel activity	PMID:18981174^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1338071	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000810	regulation of bicellular tight junction assembly	PMID:20504882^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000009	negative regulation of protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903861	positive regulation of dendrite extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902306	negative regulation of sodium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901380	negative regulation of potassium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901016	regulation of potassium ion transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0086005	ventricular cardiac muscle cell action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:20504882^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:106183)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060306	regulation of membrane repolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735047	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	PMID:11149908^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	F		Seeded From UniProt	complete
enables	GO:0019870	potassium channel inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	F		Seeded From UniProt	complete
enables	GO:0019870	potassium channel inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735047	F		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
enables	GO:0015459	potassium channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010766	negative regulation of sodium ion transport	PMID:21300902^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4940977	P	regulates_o_occurs_in:(EMAPA:32860) regulates_o_occurs_in:(CL:0002063)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010766	negative regulation of sodium ion transport	PMID:18524855^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3846431	P	regulates_o_occurs_in:(EMAPA:17896)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010766	negative regulation of sodium ion transport	PMID:17715136^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010766	negative regulation of sodium ion transport	PMID:11149908^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010766	negative regulation of sodium ion transport	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5U1Z5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010765	positive regulation of sodium ion transport	PMID:18981174^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1338071	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010038	response to metal ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009651	response to salt stress	PMID:18524855^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3846431	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006513	protein monoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735047	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003254	regulation of membrane depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96PU5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003085	negative regulation of systemic arterial blood pressure	PMID:18524855^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3846431	P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0174	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Edinger, RS et al. (2009) Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J. Biol. Chem. 284 150-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Raikwar, NS et al. (2010) Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia. Am. J. Physiol. Renal Physiol. 299 F436-44 PubMed GONUTS page
↑ ^4.0 ^4.1 Kamynina, E et al. (2001) A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEB J. 15 204-214 PubMed GONUTS page
↑ Kimura, T et al. (2011) Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc. Natl. Acad. Sci. U.S.A. 108 3216-21 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Shi, PP et al. (2008) Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am. J. Physiol. Renal Physiol. 295 F462-70 PubMed GONUTS page
↑ Lee, IH et al. (2007) Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J. Biol. Chem. 282 29866-73 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18981174-2] 2.0 ^2.1 Edinger, RS et al. (2009) Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J. Biol. Chem. 284 150-7 PubMed GONUTS page

[PMID:20504882-3] 3.0 ^3.1 Raikwar, NS et al. (2010) Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia. Am. J. Physiol. Renal Physiol. 299 F436-44 PubMed GONUTS page

[PMID:11149908-4] 4.0 ^4.1 Kamynina, E et al. (2001) A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEB J. 15 204-214 PubMed GONUTS page

[PMID:21300902-5] Kimura, T et al. (2011) Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc. Natl. Acad. Sci. U.S.A. 108 3216-21 PubMed GONUTS page

[PMID:18524855-6] 6.0 ^6.1 ^6.2 Shi, PP et al. (2008) Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am. J. Physiol. Renal Physiol. 295 F462-70 PubMed GONUTS page

[PMID:17715136-7] Lee, IH et al. (2007) Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J. Biol. Chem. 282 29866-73 PubMed GONUTS page

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MOUSE:NED4L

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