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HUMAN:RFFL
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RFFL (ECO:0000312 with HGNC:HGNC:24821) (synonyms: RNF189, RNF34L) | |
| Protein Name(s) | E3 ubiquitin-protein ligase rififylin (ECO:0000305)
Caspase regulator CARP2 Caspases-8 and -10-associated RING finger protein 2 CARP-2 FYVE-RING finger protein Sakura Fring RING finger and FYVE-like domain-containing protein 1 RING finger protein 189 RING finger protein 34-like | |
| External Links | ||
| UniProt | Q8WZ73 | |
| EMBL | AF434816 AY098935 AK093112 CR933651 CH471147 CH471147 CH471147 CH471147 CH471147 BC015681 BC028424 | |
| CCDS | CCDS11286.1 | |
| RefSeq | NP_001017368.1 | |
| UniGene | Hs.13680 | |
| PDB | 1Y02 | |
| PDBsum | 1Y02 | |
| ProteinModelPortal | Q8WZ73 | |
| SMR | Q8WZ73 | |
| BioGrid | 125593 | |
| IntAct | Q8WZ73 | |
| STRING | 9606.ENSP00000326170 | |
| iPTMnet | Q8WZ73 | |
| PhosphoSite | Q8WZ73 | |
| SwissPalm | Q8WZ73 | |
| BioMuta | RFFL | |
| DMDM | 74760639 | |
| EPD | Q8WZ73 | |
| MaxQB | Q8WZ73 | |
| PaxDb | Q8WZ73 | |
| PRIDE | Q8WZ73 | |
| DNASU | 117584 | |
| Ensembl | ENST00000315249 ENST00000394597 ENST00000413582 ENST00000415395 ENST00000447669 ENST00000584655 | |
| GeneID | 117584 | |
| KEGG | hsa:117584 | |
| UCSC | uc002hin.2 | |
| CTD | 117584 | |
| GeneCards | RFFL | |
| HGNC | HGNC:24821 | |
| HPA | CAB008096 HPA017910 HPA019492 | |
| MIM | 609735 | |
| neXtProt | NX_Q8WZ73 | |
| PharmGKB | PA142671086 | |
| eggNOG | KOG4275 ENOG41101VR | |
| GeneTree | ENSGT00390000012719 | |
| HOGENOM | HOG000068080 | |
| HOVERGEN | HBG055079 | |
| InParanoid | Q8WZ73 | |
| OMA | HLHEVST | |
| OrthoDB | EOG70GMFS | |
| PhylomeDB | Q8WZ73 | |
| TreeFam | TF325195 | |
| UniPathway | UPA00143 | |
| ChiTaRS | RFFL | |
| EvolutionaryTrace | Q8WZ73 | |
| GeneWiki | RFFL | |
| GenomeRNAi | 117584 | |
| NextBio | 80230 | |
| PRO | PR:Q8WZ73 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WZ73 | |
| CleanEx | HS_RFFL | |
| ExpressionAtlas | Q8WZ73 | |
| Genevisible | Q8WZ73 | |
| GO | GO:0005737 GO:0016023 GO:0005829 GO:0010008 GO:0016020 GO:0005886 GO:0055038 GO:0016874 GO:0002039 GO:0002020 GO:0019901 GO:0061630 GO:0031625 GO:0008270 GO:0006886 GO:2001271 GO:1902042 GO:1901797 GO:0010804 GO:0043161 GO:0070936 GO:0042787 GO:0010762 GO:0032006 GO:0006511 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR011011 IPR001841 IPR013083 | |
| SMART | SM00184 | |
| SUPFAM | SSF57903 | |
| PROSITE | PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001271 |
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902042 |
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901797 |
negative regulation of signal transduction by p53 class mediator |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032006 |
regulation of TOR signaling |
ECO:0000305 |
curator inference used in manual assertion |
GO:0043161 GO:0070936 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010762 |
regulation of fibroblast migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010008 |
endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
NOT|part_of |
GO:0005764 |
lysosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0002947 |
tumor necrosis factor receptor superfamily complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|part_of |
GO:0000139 |
Golgi membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6804441 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055038 |
recycling endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Gan, X et al. (2012) PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat. Cell Biol. 14 686-96 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 McDonald, ER 3rd & El-Deiry, WS (2004) Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 101 6170-5 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Yang, W et al. (2007) CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation. J. Biol. Chem. 282 3273-81 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Liao, W et al. (2008) CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. Curr. Biol. 18 641-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Yang, W et al. (2008) CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. Cell Cycle 7 670-82 PubMed GONUTS page
e
n
- GO:2001271 ! negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
- GO:1901797 ! negative regulation of signal transduction by p53 class mediator
- GO:1902042 ! negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- GO:0010804 ! negative regulation of tumor necrosis factor-mediated signaling pathway
- GO:0005654 ! nucleoplasm
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