MOUSE:RAG2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rag2 (synonyms: Rag-2)
Protein Name(s)	V(D)J recombination-activating protein 2 RAG-2
External Links
UniProt	P21784
EMBL	M64796
CCDS	CCDS16462.1
PIR	A34852
RefSeq	NP_033046.1
UniGene	Mm.4988
PDB	2JWO 2V83 2V85 2V86 2V87 2V88 2V89
PDBsum	2JWO 2V83 2V85 2V86 2V87 2V88 2V89
ProteinModelPortal	P21784
SMR	P21784
BioGrid	202575
DIP	DIP-46179N
IntAct	P21784
MINT	MINT-8384500
PhosphoSite	P21784
PRIDE	P21784
Ensembl	ENSMUST00000044031 ENSMUST00000111227
GeneID	19374
KEGG	mmu:19374
UCSC	uc008lhj.1
CTD	5897
MGI	MGI:97849
eggNOG	NOG39310
HOGENOM	HOG000237346
HOVERGEN	HBG006694
InParanoid	P21784
KO	K10988
OMA	FGQKGWP
OrthoDB	EOG73804B
PhylomeDB	P21784
TreeFam	TF331236
EvolutionaryTrace	P21784
NextBio	296467
PRO	PR:P21784
Proteomes	UP000000589
Bgee	P21784
CleanEx	MM_RAG2
ExpressionAtlas	P21784
Genevestigator	P21784
GO	GO:0005634 GO:0003682 GO:0003677 GO:0035064 GO:0035091 GO:0005547 GO:0043325 GO:0080025 GO:0005546 GO:0008270 GO:0030183 GO:0002358 GO:0002326 GO:0016568 GO:0006310 GO:0046622 GO:0002331 GO:0030217 GO:0033077 GO:0002360 GO:0033151
Gene3D	2.120.10.80
InterPro	IPR011043 IPR015915 IPR004321 IPR025162 IPR011011
PANTHER	PTHR10960
Pfam	PF03089 PF13341
SUPFAM	SSF50965 SSF57903

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030183	B cell differentiation	PMID:1547487^[1]	ECO:0000315			P		Fig 3; there is a pronounced lack of mature B cells in RAG-2 deficient mice	complete CACAO 2853
involved_in	GO:0030183	B cell differentiation	PMID:1547487^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	PMID:15964836^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	PMID:15964836^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:18033247^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:18033247^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:18025461^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	PMID:1547488^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	PMID:18033247^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	PMID:1547488^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:1547488^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:18033247^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:18025461^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:15964836^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18033247^[3]	ECO:0000305	curator inference used in manual assertion	GO:0035064	C		Seeded From UniProt	complete
enables	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	PMID:15964836^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:15964836^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18033247^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18025461^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002331	pre-B cell allelic exclusion	PMID:19448632^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097519	DNA recombinase complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002590007 ZFIN:ZDB-GENE-990415-235	C		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002590007 ZFIN:ZDB-GENE-990415-235	F		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97849 PANTHER:PTN002590007 ZFIN:ZDB-GENE-990415-235	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:12629039^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046622	positive regulation of organ growth	PMID:9252127^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96561	P	regulates_o_occurs_in:(EMAPA:18768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046622	positive regulation of organ growth	PMID:9252127^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:18768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	PMID:14766966^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1342279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033151	V(D)J recombination	PMID:2360047^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97848	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:9875844^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P	results_in_acquisition_of_features_of:(CL:0000806)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030217	T cell differentiation	PMID:14595002^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030217	T cell differentiation	PMID:11980719^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P	results_in_acquisition_of_features_of:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030183	B cell differentiation	PMID:14595002^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030183	B cell differentiation	PMID:11980719^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P	results_in_acquisition_of_features_of:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002360	T cell lineage commitment	PMID:8788039^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P	occurs_in:(EMAPA:18768) occurs_in:(CL:0000084)\|occurs_in:(EMAPA:32760) occurs_in:(CL:0000084)\|occurs_in:(EMAPA:18767) occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002358	B cell homeostatic proliferation	PMID:9052834^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P	occurs_in:(EMAPA:32760)\|occurs_in:(EMAPA:18767)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002326	B cell lineage commitment	PMID:8788039^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858556	P	occurs_in:(EMAPA:18768) results_in_commitment_to:(CL:0000236)\|occurs_in(EMAPA:32760) results_in_commitment_to:(CL:0000236)\|occurs_in(EMAPA:18767) results_in_commitment_to:(CL:0000236)	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0061630	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004321	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004321	C		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004321	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8865728	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006310	DNA recombination	PMID:12606021^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shinkai, Y et al. (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68 855-67 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Elkin, SK et al. (2005) A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J. Biol. Chem. 280 28701-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Matthews, AG et al. (2007) RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 450 1106-10 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ramón-Maiques, S et al. (2007) The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc. Natl. Acad. Sci. U.S.A. 104 18993-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Mombaerts, P et al. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68 869-77 PubMed GONUTS page
↑ Hewitt, SL et al. (2009) RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat. Immunol. 10 655-64 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yurchenko, V et al. (2003) The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev. 17 581-5 PubMed GONUTS page
↑ ^9.0 ^9.1 von Freeden-Jeffry, U et al. (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7 147-54 PubMed GONUTS page
↑ Suzuki, K et al. (2004) Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. U.S.A. 101 1981-6 PubMed GONUTS page
↑ Oettinger, MA et al. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248 1517-23 PubMed GONUTS page
↑ Gao, Y et al. (1998) A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95 891-902 PubMed GONUTS page
↑ ^13.0 ^13.1 Cabana, VG et al. (2004) Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J. Lipid Res. 45 317-25 PubMed GONUTS page
↑ ^14.0 ^14.1 Dahl, R et al. (2002) Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 21 2220-30 PubMed GONUTS page
↑ ^15.0 ^15.1 Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page
↑ Young, F et al. (1997) Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells. Immunity 6 23-33 PubMed GONUTS page
↑ Ohinata, Y et al. (2003) A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. FEBS Lett. 537 1-5 PubMed GONUTS page

[PMID:1547487-1] 1.0 ^1.1 Shinkai, Y et al. (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68 855-67 PubMed GONUTS page

[PMID:15964836-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Elkin, SK et al. (2005) A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J. Biol. Chem. 280 28701-10 PubMed GONUTS page

[PMID:18033247-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Matthews, AG et al. (2007) RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 450 1106-10 PubMed GONUTS page

[PMID:18025461-4] 4.0 ^4.1 ^4.2 Ramón-Maiques, S et al. (2007) The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc. Natl. Acad. Sci. U.S.A. 104 18993-8 PubMed GONUTS page

[PMID:1547488-5] 5.0 ^5.1 ^5.2 Mombaerts, P et al. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68 869-77 PubMed GONUTS page

[PMID:19448632-6] Hewitt, SL et al. (2009) RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat. Immunol. 10 655-64 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12629039-8] Yurchenko, V et al. (2003) The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev. 17 581-5 PubMed GONUTS page

[PMID:9252127-9] 9.0 ^9.1 von Freeden-Jeffry, U et al. (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7 147-54 PubMed GONUTS page

[PMID:14766966-10] Suzuki, K et al. (2004) Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. U.S.A. 101 1981-6 PubMed GONUTS page

[PMID:2360047-11] Oettinger, MA et al. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248 1517-23 PubMed GONUTS page

[PMID:9875844-12] Gao, Y et al. (1998) A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95 891-902 PubMed GONUTS page

[PMID:14595002-13] 13.0 ^13.1 Cabana, VG et al. (2004) Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J. Lipid Res. 45 317-25 PubMed GONUTS page

[PMID:11980719-14] 14.0 ^14.1 Dahl, R et al. (2002) Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 21 2220-30 PubMed GONUTS page

[PMID:8788039-15] 15.0 ^15.1 Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page

[PMID:9052834-16] Young, F et al. (1997) Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells. Immunity 6 23-33 PubMed GONUTS page

[PMID:12606021-17] Ohinata, Y et al. (2003) A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. FEBS Lett. 537 1-5 PubMed GONUTS page

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MOUSE:RAG2

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