HUMAN:WWP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WWP2
Protein Name(s)	NEDD4-like E3 ubiquitin-protein ligase WWP2 Atrophin-1-interacting protein 2 AIP2 WW domain-containing protein 2
External Links
UniProt	O00308
EMBL	U96114 JN712744 AK126332 AK300266 AK312792 AC026468 AC092115 CH471092 BC000108 BC013645 BC064531
CCDS	CCDS10885.1 CCDS58475.1 CCDS58476.1 CCDS58477.1
RefSeq	NP_001257382.1 NP_001257383.1 NP_001257384.1 NP_008945.2 NP_955456.1 XP_005255835.1
UniGene	Hs.408458
ProteinModelPortal	O00308
SMR	O00308
BioGrid	116244
IntAct	O00308
MINT	MINT-148449
STRING	9606.ENSP00000348283
PhosphoSite	O00308
MaxQB	O00308
PaxDb	O00308
PRIDE	O00308
DNASU	11060
Ensembl	ENST00000356003 ENST00000359154 ENST00000568684 ENST00000569174
GeneID	11060
KEGG	hsa:11060
UCSC	uc002exu.2
CTD	11060
GeneCards	GC16P069796
HGNC	HGNC:16804
HPA	HPA041682
MIM	602308
neXtProt	NX_O00308
PharmGKB	PA134946925
eggNOG	COG5021
GeneTree	ENSGT00760000118966
HOGENOM	HOG000208453
HOVERGEN	HBG004134
InParanoid	O00308
KO	K05630
OMA	PRINSYV
OrthoDB	EOG7RFTGT
PhylomeDB	O00308
TreeFam	TF323658
SignaLink	O00308
UniPathway	UPA00143
ChiTaRS	WWP2
GeneWiki	WWP2
GenomeRNAi	11060
NextBio	13633274
PRO	PR:O00308
Proteomes	UP000005640
Bgee	O00308
CleanEx	HS_WWP2
ExpressionAtlas	O00308
Genevestigator	O00308
GO	GO:0005737 GO:0070062 GO:0016020 GO:0005634 GO:0000151 GO:0016874 GO:0001085 GO:0008134 GO:0004842 GO:0006464 GO:0010629 GO:0051224 GO:0043433 GO:0000122 GO:0045892 GO:0032410 GO:0043161 GO:0051865 GO:0070534 GO:0016567 GO:0042787 GO:0034765 GO:0042391 GO:1901016 GO:0046718
Gene3D	2.60.40.150
InterPro	IPR000008 IPR024928 IPR000569 IPR001202
Pfam	PF00632 PF00397
PIRSF	PIRSF001569
SMART	SM00239 SM00119 SM00456
SUPFAM	SSF49562 SSF51045 SSF56204
PROSITE	PS50237 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0016567	protein ubiquitination	PMID:22315426^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006858	extracellular transport	PMID:22315426^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1901016	regulation of potassium ion transmembrane transporter activity	PMID:17289006^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15047715^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBH0	P	Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:15047715^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBH0	P	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:17289006^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	PMID:17289006^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15047715^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBH0	C	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:19274063^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01860	F	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:15047715^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBH0	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19274063^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15047715^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBH0	P	Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9DBH0	P	Seeded From UniProt	complete
involved_in	GO:0051224	negative regulation of protein transport	PMID:18776082^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:19274063^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032410	negative regulation of transporter activity	PMID:18776082^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:18776082^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:18776082^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19651900^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11161	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19274063^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:18776082^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:19651900^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:19274063^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914144 PANTHER:PTN000134916	P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1933754 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q9HCE7	F	Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 RGD:735047 UniProtKB:P46934	P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN001679348 UniProtKB:O00308	P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861728 MGI:MGI:1914144 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:O00308 UniProtKB:Q96PU5 UniProtKB:Q9HCE7	P	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000134916 UniProtKB:O00308	P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259174 MGI:MGI:1861728 MGI:MGI:1914144 MGI:MGI:1923038 MGI:MGI:97297 PANTHER:PTN000134256 SGD:S000000927 SGD:S000002865 TAIR:locus:2135630 UniProtKB:O00308 UniProtKB:P46934 UniProtKB:Q5BDP1 UniProtKB:Q8IYU2 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HCE7 WB:WBGene00007009	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN001679348 UniProtKB:Q96J02	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029006 MGI:MGI:1202301 MGI:MGI:97297 PANTHER:PTN000134745 PomBase:SPAC11G7.02 SGD:S000000927 UniProtKB:O15033 UniProtKB:P46934 UniProtKB:Q96J02 UniProtKB:Q96PU5 UniProtKB:Q9HAU4 UniProtKB:Q9HCE7	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003557 FB:FBgn0259174 MGI:MGI:1202301 MGI:MGI:1914144 MGI:MGI:97297 PANTHER:PTN000134256 PomBase:SPAC11G7.02 PomBase:SPAC1805.15c SGD:S000000927 TAIR:locus:2135630 UniProtKB:P46934 UniProtKB:Q7Z6Z7 UniProtKB:Q9HCE7 WB:WBGene00007009	C	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202301 PANTHER:PTN000134745 SGD:S000000927 UniProtKB:Q9HCE7	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914144 PANTHER:PTN000134916 UniProtKB:O00308	P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:26280536^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:24105792^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:24105792^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	P	Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	F	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9DBH0 ensembl:ENSMUSP00000132224	P	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024928	F	Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:9169421^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:9169421^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:9647693^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	PMID:12450395^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	Reactome:R-HSA-9021523	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	Reactome:R-HSA-9021523 Reactome:R-HSA-9021520	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9021523 Reactome:R-HSA-9021520 Reactome:R-HSA-6807134	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Nabhan, JF et al. (2012) Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc. Natl. Acad. Sci. U.S.A. 109 4146-51 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Jespersen, T et al. (2007) The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc. Res. 74 64-74 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Xu, HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J. Biol. Chem. 279 23495-503 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Xu, H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 19 561-73 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Foot, NJ et al. (2008) Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112 4268-75 PubMed GONUTS page
↑ ^8.0 ^8.1 Chen, A et al. (2009) The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol. Cell. Biol. 29 5348-56 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page
↑ ^11.0 ^11.1 Lee, YI et al. (2014) Protein microarray characterization of the S-nitrosoproteome. Mol. Cell Proteomics 13 63-72 PubMed GONUTS page
↑ ^12.0 ^12.1 Pirozzi, G et al. (1997) Identification of novel human WW domain-containing proteins by cloning of ligand targets. J. Biol. Chem. 272 14611-6 PubMed GONUTS page
↑ Wood, JD et al. (1998) Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol. Cell. Neurosci. 11 149-60 PubMed GONUTS page
↑ Galinier, R et al. (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry 41 14299-305 PubMed GONUTS page

[PMID:22315426-1] 1.0 ^1.1 Nabhan, JF et al. (2012) Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc. Natl. Acad. Sci. U.S.A. 109 4146-51 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:17289006-4] 4.0 ^4.1 ^4.2 Jespersen, T et al. (2007) The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc. Res. 74 64-74 PubMed GONUTS page

[PMID:15047715-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Xu, HM et al. (2004) Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J. Biol. Chem. 279 23495-503 PubMed GONUTS page

[PMID:19274063-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Xu, H et al. (2009) WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 19 561-73 PubMed GONUTS page

[PMID:18776082-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Foot, NJ et al. (2008) Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112 4268-75 PubMed GONUTS page

[PMID:19651900-8] 8.0 ^8.1 Chen, A et al. (2009) The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol. Cell. Biol. 29 5348-56 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26280536-10] Yuan, L et al. (2015) Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat. Cell Biol. 17 1169-81 PubMed GONUTS page

[PMID:24105792-11] 11.0 ^11.1 Lee, YI et al. (2014) Protein microarray characterization of the S-nitrosoproteome. Mol. Cell Proteomics 13 63-72 PubMed GONUTS page

[PMID:9169421-12] 12.0 ^12.1 Pirozzi, G et al. (1997) Identification of novel human WW domain-containing proteins by cloning of ligand targets. J. Biol. Chem. 272 14611-6 PubMed GONUTS page

[PMID:9647693-13] Wood, JD et al. (1998) Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol. Cell. Neurosci. 11 149-60 PubMed GONUTS page

[PMID:12450395-14] Galinier, R et al. (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry 41 14299-305 PubMed GONUTS page

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HUMAN:WWP2

Contents

Annotations

Notes

References

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