DROME:IAP1

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	th (synonyms: Iap1)
Protein Name(s)	Apoptosis 1 inhibitor E3 ubiquitin-protein ligase th Inhibitor of apoptosis 1 dIAP1 Protein thread
External Links
UniProt	Q24306
EMBL	L49440 AE014296 AE014296 AE014296 BT031197 AY119524
RefSeq	NP_001261916.1 NP_001261917.1 NP_001261918.1 NP_524101.2 NP_730097.1 NP_730098.1
UniGene	Dm.6466
PDB	1JD4 1JD5 1JD6 1Q4Q 1SDZ 1SE0 3SIP 3SIQ
PDBsum	1JD4 1JD5 1JD6 1Q4Q 1SDZ 1SE0 3SIP 3SIQ
ProteinModelPortal	Q24306
SMR	Q24306
BioGrid	65064
IntAct	Q24306
MINT	MINT-1601077
MEROPS	I32.009
EnsemblMetazoa	FBtr0075499 FBtr0075500 FBtr0075501 FBtr0333617 FBtr0333618 FBtr0333619
GeneID	39753
KEGG	dme:Dmel_CG12284
CTD	7054
FlyBase	FBgn0260635
eggNOG	NOG243347
GeneTree	ENSGT00500000044782
InParanoid	Q24306
KO	K04725
OMA	QKPQQLA
OrthoDB	EOG78H3TF
PhylomeDB	Q24306
Reactome	REACT_241007
SignaLink	Q24306
EvolutionaryTrace	Q24306
GenomeRNAi	39753
NextBio	815208
PMAP-CutDB	Q24306
Proteomes	UP000000803
Bgee	Q24306
ExpressionAtlas	Q24306
GO	GO:0005737 GO:0005634 GO:0004869 GO:0019899 GO:0019788 GO:0031625 GO:0004842 GO:0008270 GO:0048800 GO:0006915 GO:0007298 GO:0009987 GO:0008407 GO:0008354 GO:0097340 GO:1990001 GO:0007275 GO:0043066 GO:0046673 GO:0043154 GO:0090263 GO:0031398 GO:0051865 GO:0070936 GO:0000209 GO:0042787 GO:0007423 GO:0045035 GO:0007289 GO:0007283 GO:0016055
Gene3D	1.10.1170.10 3.30.40.10
InterPro	IPR001370 IPR001841 IPR013083
Pfam	PF00653
SMART	SM00238 SM00184
PROSITE	PS01282 PS50143 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0060243	negative regulation of cell growth involved in contact inhibition	PMID:10481910^[1]	ECO:0000314			P	Figure 5. Cells in Embryos Homozygous Mutant for DIAP1 Show Premature and Increased DNA Fragmentation and an Increase in DIAP1-Inhibitable Caspase Activity.	complete CACAO 5949
	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:10481910^[1]	ECO:0000314			P	Figure 7-DIAP1 inhibits caspase activity and is essential for cell survival	complete CACAO 6046
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:22304967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:18259196^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17397804^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 MGI:MGI:107572 PANTHER:PTN000799425	P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015247 FB:FBgn0260635 PANTHER:PTN000799425 UniProtKB:P98170	F	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015247 FB:FBgn0260635 MGI:MGI:107572 PANTHER:PTN000005168 UniProtKB:O15392 UniProtKB:P98170	P	Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015247 FB:FBgn0260635 PANTHER:PTN000005168 UniProtKB:O15392	F	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 MGI:MGI:1197007 MGI:MGI:1197009 PANTHER:PTN000799425 UniProtKB:P98170 UniProtKB:Q13489 UniProtKB:Q13490	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 MGI:MGI:107572 MGI:MGI:1203517 PANTHER:PTN000005166 RGD:620692 UniProtKB:O15392 UniProtKB:P98170 UniProtKB:Q13489 UniProtKB:Q13490 UniProtKB:Q96CA5	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260635 PANTHER:PTN000005166 PomBase:SPCC962.02c RGD:620690 RGD:620692 UniProtKB:O15392 UniProtKB:P98170 UniProtKB:Q13489 UniProtKB:Q13490 UniProtKB:Q96CA5	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21912646^[6]	ECO:0000255	match to sequence model evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
enables	GO:1990381	ubiquitin-specific protease binding	PMID:24362437^[7]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0033738	F	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:23940367^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	PMID:23940367^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:23409089^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044390	ubiquitin-like protein conjugating enzyme binding	PMID:21145488^[10]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0035853	F	Seeded From UniProt	complete
enables	GO:0061663	NEDD8 ligase activity	PMID:21145488^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045116	protein neddylation	PMID:21145488^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045035	sensory organ precursor cell division	PMID:19822670^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0086657	P	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:19026784^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:17205079^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:17205079^[13]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0015247	F	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:17205079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:17205079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903688	positive regulation of border follicle cell migration	PMID:17483425^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17464325^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17464325^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18166655^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18166655^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0019972	P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18166655^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010501	P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16485033^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0019972	P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16485033^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0263864	P	Seeded From UniProt	complete
enables	GO:0089720	caspase binding	PMID:16485033^[17]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0010501	F	Seeded From UniProt	complete
involved_in	GO:0046673	negative regulation of compound eye retinal cell programmed cell death	PMID:16485033^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16485033^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0026404	P	Seeded From UniProt	complete
enables	GO:0089720	caspase binding	PMID:16485033^[17]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0019972	F	Seeded From UniProt	complete
involved_in	GO:0022416	chaeta development	PMID:16222340^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048800	antennal morphogenesis	PMID:15464574^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007298	border follicle cell migration	PMID:15242648^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007298	border follicle cell migration	PMID:15242648^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010333	P	Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	PMID:15107838^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	PMID:15107838^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12938178^[22]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007289	spermatid nucleus differentiation	PMID:14737191^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:12021769^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	PMID:12021769^[24]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0011217	F	Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:12021769^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:11337486^[25]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10675328^[26]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0011706	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10675328^[26]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003997	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10675328^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0011706	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10675328^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003997	P	Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	PMID:10481910^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0097340	inhibition of cysteine-type endopeptidase activity	PMID:10481910^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	PMID:10481910^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10200511^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:22304967^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-390120	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:11139272^[28] PMID:12006672^[29] PMID:11178240^[30] PMID:10511707^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:12850443^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008354	germ cell migration	PMID:12814944^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12072176^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:12072176^[34] PMID:11139276^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:11178240^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Wang, SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 453-63 PubMed GONUTS page
↑ ^2.0 ^2.1 Hanson, AJ et al. (2012) XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol. Cell 45 619-28 PubMed GONUTS page
↑ Khan, FS et al. (2008) The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. Cell Death Differ. 15 1073-83 PubMed GONUTS page
↑ Igaki, T et al. (2007) Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem. Biophys. Res. Commun. 356 993-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page
↑ Yang, CS et al. (2014) The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Cell Death Differ. 21 604-11 PubMed GONUTS page
↑ ^8.0 ^8.1 Yeh, TC & Bratton, SB (2013) Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting. Proc. Natl. Acad. Sci. U.S.A. 110 14284-9 PubMed GONUTS page
↑ Lindsley, DL et al. (2013) Anent the genomics of spermatogenesis in Drosophila melanogaster. PLoS ONE 8 e55915 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Broemer, M et al. (2010) Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. Mol. Cell 40 810-22 PubMed GONUTS page
↑ Koto, A et al. (2009) Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J. Cell Biol. 187 219-31 PubMed GONUTS page
↑ Ditzel, M et al. (2008) Inactivation of effector caspases through nondegradative polyubiquitylation. Mol. Cell 32 540-53 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Herman-Bachinsky, Y et al. (2007) Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death Differ. 14 861-71 PubMed GONUTS page
↑ Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page
↑ ^15.0 ^15.1 Baum, JS et al. (2007) The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 14 1508-17 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Ribeiro, PS et al. (2007) DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J. Cell Biol. 179 1467-80 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Leulier, F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 13 1663-74 PubMed GONUTS page
↑ Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page
↑ Cullen, K & McCall, K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev. Biol. 275 82-92 PubMed GONUTS page
↑ ^20.0 ^20.1 Geisbrecht, ER & Montell, DJ (2004) A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration. Cell 118 111-25 PubMed GONUTS page
↑ ^21.0 ^21.1 Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page
↑ Lawen, A (2003) Apoptosis-an introduction. Bioessays 25 888-96 PubMed GONUTS page
↑ Huh, JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2 E15 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Ryoo, HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 432-8 PubMed GONUTS page
↑ Harvey, NL et al. (2001) Characterization of the Drosophila caspase, DAMM. J. Biol. Chem. 276 25342-50 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Goyal, L et al. (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19 589-97 PubMed GONUTS page
↑ Hawkins, CJ et al. (1998) Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells. Cell Death Differ. 5 569-76 PubMed GONUTS page
↑ Kumar, S (2000) Cell death in the fly comes of age. Cell Death Differ. 7 1021-4 PubMed GONUTS page
↑ Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
↑ ^30.0 ^30.1 Tittel, JN & Steller, H (2000) A comparison of programmed cell death between species. Genome Biol. 1 REVIEWS0003 PubMed GONUTS page
↑ Abrams, JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 9 435-40 PubMed GONUTS page
↑ Ou, CY et al. (2003) Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genet. 19 382-9 PubMed GONUTS page
↑ Coffman, CR (2003) Cell migration and programmed cell death of Drosophila germ cells. Ann. N. Y. Acad. Sci. 995 117-26 PubMed GONUTS page
↑ ^34.0 ^34.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
↑ Kumar, S & Doumanis, J (2000) The fly caspases. Cell Death Differ. 7 1039-44 PubMed GONUTS page

[PMID:10481910-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Wang, SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 453-63 PubMed GONUTS page

[PMID:22304967-2] 2.0 ^2.1 Hanson, AJ et al. (2012) XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol. Cell 45 619-28 PubMed GONUTS page

[PMID:18259196-3] Khan, FS et al. (2008) The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. Cell Death Differ. 15 1073-83 PubMed GONUTS page

[PMID:17397804-4] Igaki, T et al. (2007) Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem. Biophys. Res. Commun. 356 993-7 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21912646-6] Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page

[PMID:24362437-7] Yang, CS et al. (2014) The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Cell Death Differ. 21 604-11 PubMed GONUTS page

[PMID:23940367-8] 8.0 ^8.1 Yeh, TC & Bratton, SB (2013) Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting. Proc. Natl. Acad. Sci. U.S.A. 110 14284-9 PubMed GONUTS page

[PMID:23409089-9] Lindsley, DL et al. (2013) Anent the genomics of spermatogenesis in Drosophila melanogaster. PLoS ONE 8 e55915 PubMed GONUTS page

[PMID:21145488-10] 10.0 ^10.1 ^10.2 Broemer, M et al. (2010) Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. Mol. Cell 40 810-22 PubMed GONUTS page

[PMID:19822670-11] Koto, A et al. (2009) Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J. Cell Biol. 187 219-31 PubMed GONUTS page

[PMID:19026784-12] Ditzel, M et al. (2008) Inactivation of effector caspases through nondegradative polyubiquitylation. Mol. Cell 32 540-53 PubMed GONUTS page

[PMID:17205079-13] 13.0 ^13.1 ^13.2 ^13.3 Herman-Bachinsky, Y et al. (2007) Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death Differ. 14 861-71 PubMed GONUTS page

[PMID:17483425-14] Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page

[PMID:17464325-15] 15.0 ^15.1 Baum, JS et al. (2007) The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 14 1508-17 PubMed GONUTS page

[PMID:18166655-16] 16.0 ^16.1 ^16.2 Ribeiro, PS et al. (2007) DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J. Cell Biol. 179 1467-80 PubMed GONUTS page

[PMID:16485033-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Leulier, F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 13 1663-74 PubMed GONUTS page

[PMID:16222340-18] Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page

[PMID:15464574-19] Cullen, K & McCall, K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev. Biol. 275 82-92 PubMed GONUTS page

[PMID:15242648-20] 20.0 ^20.1 Geisbrecht, ER & Montell, DJ (2004) A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration. Cell 118 111-25 PubMed GONUTS page

[PMID:15107838-21] 21.0 ^21.1 Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page

[PMID:12938178-22] Lawen, A (2003) Apoptosis-an introduction. Bioessays 25 888-96 PubMed GONUTS page

[PMID:14737191-23] Huh, JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2 E15 PubMed GONUTS page

[PMID:12021769-24] 24.0 ^24.1 ^24.2 Ryoo, HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 432-8 PubMed GONUTS page

[PMID:11337486-25] Harvey, NL et al. (2001) Characterization of the Drosophila caspase, DAMM. J. Biol. Chem. 276 25342-50 PubMed GONUTS page

[PMID:10675328-26] 26.0 ^26.1 ^26.2 ^26.3 Goyal, L et al. (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19 589-97 PubMed GONUTS page

[PMID:10200511-27] Hawkins, CJ et al. (1998) Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells. Cell Death Differ. 5 569-76 PubMed GONUTS page

[PMID:11139272-28] Kumar, S (2000) Cell death in the fly comes of age. Cell Death Differ. 7 1021-4 PubMed GONUTS page

[PMID:12006672-29] Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page

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[PMID:12850443-32] Ou, CY et al. (2003) Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genet. 19 382-9 PubMed GONUTS page

[PMID:12814944-33] Coffman, CR (2003) Cell migration and programmed cell death of Drosophila germ cells. Ann. N. Y. Acad. Sci. 995 117-26 PubMed GONUTS page

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