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DROME:IAP1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) th (synonyms: Iap1)
Protein Name(s) Apoptosis 1 inhibitor

E3 ubiquitin-protein ligase th Inhibitor of apoptosis 1 dIAP1 Protein thread

External Links
UniProt Q24306
EMBL L49440
AE014296
AE014296
AE014296
BT031197
AY119524
RefSeq NP_001261916.1
NP_001261917.1
NP_001261918.1
NP_524101.2
NP_730097.1
NP_730098.1
UniGene Dm.6466
PDB 1JD4
1JD5
1JD6
1Q4Q
1SDZ
1SE0
3SIP
3SIQ
PDBsum 1JD4
1JD5
1JD6
1Q4Q
1SDZ
1SE0
3SIP
3SIQ
ProteinModelPortal Q24306
SMR Q24306
BioGrid 65064
IntAct Q24306
MINT MINT-1601077
MEROPS I32.009
EnsemblMetazoa FBtr0075499
FBtr0075500
FBtr0075501
FBtr0333617
FBtr0333618
FBtr0333619
GeneID 39753
KEGG dme:Dmel_CG12284
CTD 7054
FlyBase FBgn0260635
eggNOG NOG243347
GeneTree ENSGT00500000044782
InParanoid Q24306
KO K04725
OMA QKPQQLA
OrthoDB EOG78H3TF
PhylomeDB Q24306
Reactome REACT_241007
SignaLink Q24306
EvolutionaryTrace Q24306
GenomeRNAi 39753
NextBio 815208
PMAP-CutDB Q24306
Proteomes UP000000803
Bgee Q24306
ExpressionAtlas Q24306
GO GO:0005737
GO:0005634
GO:0004869
GO:0019899
GO:0019788
GO:0031625
GO:0004842
GO:0008270
GO:0048800
GO:0006915
GO:0007298
GO:0009987
GO:0008407
GO:0008354
GO:0097340
GO:1990001
GO:0007275
GO:0043066
GO:0046673
GO:0043154
GO:0090263
GO:0031398
GO:0051865
GO:0070936
GO:0000209
GO:0042787
GO:0007423
GO:0045035
GO:0007289
GO:0007283
GO:0016055
Gene3D 1.10.1170.10
3.30.40.10
InterPro IPR001370
IPR001841
IPR013083
Pfam PF00653
SMART SM00238
SM00184
PROSITE PS01282
PS50143
PS50089

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0060243

negative regulation of cell growth involved in contact inhibition

PMID:10481910[1]

IDA: Inferred from Direct Assay

P

Figure 5. Cells in Embryos Homozygous Mutant for DIAP1 Show Premature and Increased DNA Fragmentation and an Increase in DIAP1-Inhibitable Caspase Activity.

complete
CACAO 5949

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:10481910[1]

IDA: Inferred from Direct Assay

P

Figure 7-DIAP1 inhibits caspase activity and is essential for cell survival

complete
CACAO 6046

GO:0000209

protein polyubiquitination

PMID:17205079[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0004842

ubiquitin-protein transferase activity

PMID:22304967[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004869

cysteine-type endopeptidase inhibitor activity

PMID:10481910[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10481910[1]

IPI: Inferred from Physical Interaction

FB:FBgn0003997

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10481910[1]

IPI: Inferred from Physical Interaction

FB:FBgn0010501

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10481910[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q24106

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10675328[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q24106

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10675328[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q24475

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10675329[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9XYF4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11818065[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q24475

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021769[7]

IPI: Inferred from Physical Interaction

FB:FBgn0003997

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021769[7]

IPI: Inferred from Physical Interaction

FB:FBgn0011706

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021769[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q24106

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021769[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q24475

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021771[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q24106

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021771[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q24475

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12021771[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q9XYF4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12356728[9]

IPI: Inferred from Physical Interaction

FB:FBgn0040308

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14517550[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q24106

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14517550[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q9XYF4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15242648[11]

IPI: Inferred from Physical Interaction

UniProtKB:P25843

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16887178[12]

IPI: Inferred from Physical Interaction

FB:FBgn0086657

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16887178[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q86PE7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17397804[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VFJ3

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18259196[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VFJ3

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20700104[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q9XYF4

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:17464325[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:17464325[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10675328[4]

IPI: Inferred from Physical Interaction

FB:FBgn0003997

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10675328[4]

IPI: Inferred from Physical Interaction

FB:FBgn0011706

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:12072176[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:12938178[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

PMID:11178240[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

PMID:23409089[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007289

spermatid nucleus differentiation

PMID:14737191[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007298

border follicle cell migration

PMID:15242648[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0010333

P

Seeded From UniProt

complete

GO:0007298

border follicle cell migration

PMID:15242648[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007298

border follicle cell migration

PMID:17483425[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007423

sensory organ development

PMID:16222340[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

PMID:21912646[24]

ISM: Inferred from Sequence Model

F

Seeded From UniProt

Missing: with/from

GO:0008354

germ cell migration

PMID:12814944[25]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008407

chaeta morphogenesis

PMID:19822670[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

GO:0016874

ligase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

GO:0031398

positive regulation of protein ubiquitination

PMID:19026784[27]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031624

ubiquitin conjugating enzyme binding

PMID:12021769[7]

IPI: Inferred from Physical Interaction

FB:FBgn0011217

F

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:17205079[2]

IPI: Inferred from Physical Interaction

FB:FBgn0015247

F

Seeded From UniProt

complete

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

PMID:12850443[28]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043027

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

PMID:15107838[29]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:10200511[30]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:10511707[31]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:10675328[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0003997

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:10675328[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0011706

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:11139272[32]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:11178240[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:12006672[33]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:17397804[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:18259196[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:11139276[34]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:11337486[35]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:12072176[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[36]

IGI: Inferred from Genetic Interaction

FB:FBgn0019972

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[36]

IGI: Inferred from Genetic Interaction

FB:FBgn0026404

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16485033[36]

IGI: Inferred from Genetic Interaction

FB:FBgn0263864

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:18166655[37]

IGI: Inferred from Genetic Interaction

FB:FBgn0010501

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:18166655[37]

IGI: Inferred from Genetic Interaction

FB:FBgn0019972

P

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:18166655[37]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0044390

ubiquitin-like protein conjugating enzyme binding

PMID:21145488[38]

IPI: Inferred from Physical Interaction

FB:FBgn0035853

F

Seeded From UniProt

complete

GO:0045035

sensory organ precursor cell division

PMID:19822670[26]

IGI: Inferred from Genetic Interaction

FB:FBgn0086657

P

Seeded From UniProt

complete

GO:0045116

protein neddylation

PMID:21145488[38]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046673

negative regulation of compound eye retinal cell programmed cell death

PMID:16485033[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048800

antennal morphogenesis

PMID:15464574[39]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051865

protein autoubiquitination

PMID:12021769[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0051865

protein autoubiquitination

PMID:17205079[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0061630

ubiquitin protein ligase activity

PMID:12021769[7]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0061630

ubiquitin protein ligase activity

PMID:17205079[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0061630

ubiquitin protein ligase activity

PMID:23940367[40]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0061663

NEDD8 ligase activity

PMID:21145488[38]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0070936

protein K48-linked ubiquitination

PMID:23940367[40]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0089720

caspase binding

PMID:16485033[36]

IPI: Inferred from Physical Interaction

FB:FBgn0010501

F

Seeded From UniProt

complete

GO:0089720

caspase binding

PMID:16485033[36]

IPI: Inferred from Physical Interaction

FB:FBgn0019972

F

Seeded From UniProt

complete

GO:0090263

positive regulation of canonical Wnt signaling pathway

PMID:22304967[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097340

inhibition of cysteine-type endopeptidase activity

PMID:10481910[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:1990001

inhibition of cysteine-type endopeptidase activity involved in apoptotic process

PMID:10481910[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1990381

ubiquitin-specific protease binding

PMID:24362437[41]

IPI: Inferred from Physical Interaction

FB:FBgn0033738

F

Seeded From UniProt

complete

GO:2001271

negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

PMID:15107838[29]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

NOT

GO:0005876

spindle microtubule

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005232

C

Seeded From UniProt

complete

NOT

GO:0090307

mitotic spindle assembly

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005232

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Wang, SL et al. (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 453-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Herman-Bachinsky, Y et al. (2007) Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death Differ. 14 861-71 PubMed GONUTS page
  3. 3.0 3.1 Hanson, AJ et al. (2012) XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol. Cell 45 619-28 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Goyal, L et al. (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19 589-97 PubMed GONUTS page
  5. Meier, P et al. (2000) The Drosophila caspase DRONC is regulated by DIAP1. EMBO J. 19 598-611 PubMed GONUTS page
  6. Christich, A et al. (2002) The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr. Biol. 12 137-40 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Ryoo, HD et al. (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 432-8 PubMed GONUTS page
  8. 8.0 8.1 8.2 Wilson, R et al. (2002) The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat. Cell Biol. 4 445-50 PubMed GONUTS page
  9. Tenev, T et al. (2002) Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1. EMBO J. 21 5118-29 PubMed GONUTS page
  10. 10.0 10.1 Chai, J et al. (2003) Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat. Struct. Biol. 10 892-8 PubMed GONUTS page
  11. 11.0 11.1 11.2 Geisbrecht, ER & Montell, DJ (2004) A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration. Cell 118 111-25 PubMed GONUTS page
  12. 12.0 12.1 Kuranaga, E et al. (2006) Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126 583-96 PubMed GONUTS page
  13. 13.0 13.1 Igaki, T et al. (2007) Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem. Biophys. Res. Commun. 356 993-7 PubMed GONUTS page
  14. 14.0 14.1 Khan, FS et al. (2008) The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. Cell Death Differ. 15 1073-83 PubMed GONUTS page
  15. Yang, CS et al. (2010) Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J. 29 3196-207 PubMed GONUTS page
  16. 16.0 16.1 Baum, JS et al. (2007) The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 14 1508-17 PubMed GONUTS page
  17. 17.0 17.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
  18. Lawen, A (2003) Apoptosis-an introduction. Bioessays 25 888-96 PubMed GONUTS page
  19. 19.0 19.1 Tittel, JN & Steller, H (2000) A comparison of programmed cell death between species. Genome Biol. 1 REVIEWS0003 PubMed GONUTS page
  20. Lindsley, DL et al. (2013) Anent the genomics of spermatogenesis in Drosophila melanogaster. PLoS ONE 8 e55915 PubMed GONUTS page
  21. Huh, JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2 E15 PubMed GONUTS page
  22. Mathieu, J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176 1579-90 PubMed GONUTS page
  23. Kanuka, H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24 3793-806 PubMed GONUTS page
  24. Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page
  25. Coffman, CR (2003) Cell migration and programmed cell death of Drosophila germ cells. Ann. N. Y. Acad. Sci. 995 117-26 PubMed GONUTS page
  26. 26.0 26.1 Koto, A et al. (2009) Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J. Cell Biol. 187 219-31 PubMed GONUTS page
  27. Ditzel, M et al. (2008) Inactivation of effector caspases through nondegradative polyubiquitylation. Mol. Cell 32 540-53 PubMed GONUTS page
  28. Ou, CY et al. (2003) Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genet. 19 382-9 PubMed GONUTS page
  29. 29.0 29.1 Yan, N et al. (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat. Struct. Mol. Biol. 11 420-8 PubMed GONUTS page
  30. Hawkins, CJ et al. (1998) Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells. Cell Death Differ. 5 569-76 PubMed GONUTS page
  31. Abrams, JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol. 9 435-40 PubMed GONUTS page
  32. Kumar, S (2000) Cell death in the fly comes of age. Cell Death Differ. 7 1021-4 PubMed GONUTS page
  33. Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
  34. Kumar, S & Doumanis, J (2000) The fly caspases. Cell Death Differ. 7 1039-44 PubMed GONUTS page
  35. Harvey, NL et al. (2001) Characterization of the Drosophila caspase, DAMM. J. Biol. Chem. 276 25342-50 PubMed GONUTS page
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