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PMID:12006672

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Citation

Gorski, S and Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9:59-69

Abstract

Programmed cell death (PCD) is an essential and wide-spread physiological process that results in the elimination of cells. Genes required to carry out this process have been identified, and many of these remain the subjects of intense investigation. Here, we describe PCD, its functions, and some of the consequences when it goes awry. We review PCD in the model system, the fruit fly, Drosophila melanogaster, with a particular emphasis on cell death gene discovery resulting from both genetics and genomics-based approaches.

Links

PubMed Online version:10.1152/physiolgenomics.00114.2001

Keywords

Animals; Apoptosis/genetics; Apoptosis/physiology; Biological Evolution; Drosophila melanogaster/cytology; Drosophila melanogaster/genetics; Gene Expression Profiling; Genes, Insect; Genome; Humans; Models, Biological

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4K7P1

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:A0A0B4K7P1

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:DL

involved_in

GO:0046667: compound eye retinal cell programmed cell death

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ICCR

involved_in

GO:0007156: homophilic cell adhesion via plasma membrane adhesion molecules

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ICCR

involved_in

GO:0046667: compound eye retinal cell programmed cell death

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY6

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY6

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY7

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY7

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IH92

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IH92

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMZ4

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9N6D8

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VEM2

involved_in

GO:0043066: negative regulation of apoptotic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9N6D8

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9N6D8

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

DROME:HID

involved_in

GO:0012501: programmed cell death

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

DROME:RPR

involved_in

GO:0012501: programmed cell death

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

DROME:Q8IMZ4

involved_in

GO:0030330: DNA damage response, signal transduction by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

DROME:Q8IMZ4

involved_in

GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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