MOUSE:RING2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rnf2 (synonyms: DinG, Ring1b)
Protein Name(s)	E3 ubiquitin-protein ligase RING2 RING finger protein 1B RING1b RING finger protein 2
External Links
UniProt	Q9CQJ4
EMBL	Y12880 Y12783 AK145767 AK012358 AK013124 AK030319 AK090066 CT010297 BC020122
CCDS	CCDS15362.1
RefSeq	NP_035407.1
UniGene	Mm.474038
PDB	2CKL
PDBsum	2CKL
ProteinModelPortal	Q9CQJ4
SMR	Q9CQJ4
BioGrid	202919
DIP	DIP-36109N
IntAct	Q9CQJ4
MINT	MINT-1341250
STRING	10090.ENSMUSP00000075476
PhosphoSite	Q9CQJ4
MaxQB	Q9CQJ4
PaxDb	Q9CQJ4
PRIDE	Q9CQJ4
Ensembl	ENSMUST00000076110 ENSMUST00000187048
GeneID	19821
KEGG	mmu:19821
UCSC	uc007cyx.1
CTD	6045
MGI	MGI:1101759
eggNOG	NOG324386
GeneTree	ENSGT00390000016977
HOGENOM	HOG000273917
HOVERGEN	HBG079942
InParanoid	Q9CQJ4
KO	K10695
OMA	MELYFAP
OrthoDB	EOG7NGQC3
PhylomeDB	Q9CQJ4
TreeFam	TF105501
Reactome	REACT_188970
UniPathway	UPA00143
EvolutionaryTrace	Q9CQJ4
NextBio	297285
PRO	PR:Q9CQJ4
Proteomes	UP000000589
Bgee	Q9CQJ4
CleanEx	MM_RNF2
Genevestigator	Q9CQJ4
GO	GO:0000791 GO:0000792 GO:0071339 GO:0016604 GO:0005634 GO:0031519 GO:0035102 GO:0001739 GO:0000151 GO:0003682 GO:0016874 GO:0061630 GO:0008270 GO:0009948 GO:0001702 GO:0036353 GO:0016574 GO:0000278 GO:0000122 GO:0006351
Gene3D	3.30.40.10
InterPro	IPR018957 IPR001841 IPR013083 IPR017907
Pfam	PF00097
SMART	SM00184
PROSITE	PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0031519	PcG protein complex	PMID:28596365^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	PMID:23486062^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071339	MLL1 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
involved_in	GO:0036353	histone H2A-K119 monoubiquitination	PMID:24034696^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99496	F		Seeded From UniProt	complete
contributes_to	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99496	F		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
	GO:0007281	germ cell development	PMID:23486062^[2]	ECO:0000315			P		In figure 1 Rnf2 is shown to regulate primordial germ cell development, as seen through the effects of Rnf2 mutants	complete CACAO 6941
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24034696^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071535	RING-like zinc finger domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	F		Seeded From UniProt	complete
part_of	GO:0071339	MLL1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:16359901^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035518	histone H2A monoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	P		Seeded From UniProt	complete
part_of	GO:0035102	PRC1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
part_of	GO:0031519	PcG protein complex	PMID:16624538^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031519	PcG protein complex	PMID:16359901^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031519	PcG protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:12183370^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016574	histone ubiquitination	PMID:15525528^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1101770	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016574	histone ubiquitination	PMID:16359901^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009948	anterior/posterior axis specification	PMID:12183370^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447529	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22770845^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14557078^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
contributes_to	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16687444^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:96189)\|has_participant:(MGI:MGI:98494)\|has_participant:(MGI:MGI:96185)\|has_participant:(MGI:MGI:96186)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15741318^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:96177)\|has_participant:(MGI:MGI:96182)\|has_participant:(MGI:MGI:96184)\|has_participant:(MGI:MGI:96185)\|has_participant:(MGI:MGI:96187)\|has_participant:(MGI:MGI:96189)\|has_participant:(MGI:MGI:96197)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:12183370^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	F		Seeded From UniProt	complete
part_of	GO:0001739	sex chromatin	PMID:15525528^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:12589020^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653961	P		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:18311137^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	PMID:18311137^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000278	mitotic cell cycle	PMID:12589020^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653961	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:16359901^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99496	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16687444^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057) has_regulation_target:(MGI:MGI:96170)\|occurs_in(CL:0000057) has_regulation_target:(MGI:MGI:96179)\|occurs_in(CL:0000057) has_regulation_target:(MGI:MGI:96184)\|occurs_in(CL:0000057) has_regulation_target:(MGI:MGI:107730)\|occurs_in(CL:0000057) has_regulation_target:(MGI:MGI:96189)\|occurs_in(CL:0000057) has_regulation_target:(MGI:MGI:96199)\|occurs_in(CL:0000057) has_regulation_target:(MGI:MGI:96209)\|occurs_in(CL:0000057) has_regulation_target:(MGI:MGI:96202)	Seeded From UniProt	complete
enables	GO:0071535	RING-like zinc finger domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	F		Seeded From UniProt	complete
part_of	GO:0071339	MLL1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	C		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	P		Seeded From UniProt	complete
involved_in	GO:0035518	histone H2A monoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	P		Seeded From UniProt	complete
part_of	GO:0035102	PRC1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	C		Seeded From UniProt	complete
part_of	GO:0031519	PcG protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	F		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99496 ensembl:ENSP00000356480	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Almeida, M et al. (2017) PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Science 356 1081-1084 PubMed GONUTS page
↑ ^2.0 ^2.1 Yokobayashi, S et al. (2013) PRC1 coordinates timing of sexual differentiation of female primordial germ cells. Nature 495 236-40 PubMed GONUTS page
↑ ^3.0 ^3.1 Frangini, A et al. (2013) The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 51 647-61 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Cao, R et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20 845-54 PubMed GONUTS page
↑ Lorente, M et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech. Dev. 123 312-20 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Suzuki, M et al. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129 4171-83 PubMed GONUTS page
↑ ^7.0 ^7.1 de Napoles, M et al. (2004) Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev. Cell 7 663-76 PubMed GONUTS page
↑ Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page
↑ Kaneko, T et al. (2003) The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Gene 315 183-92 PubMed GONUTS page
↑ ^10.0 ^10.1 Fujimura, Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133 2371-81 PubMed GONUTS page
↑ Isono, K et al. (2005) Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 19 536-41 PubMed GONUTS page
↑ ^12.0 ^12.1 Voncken, JW et al. (2003) Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc. Natl. Acad. Sci. U.S.A. 100 2468-73 PubMed GONUTS page
↑ ^13.0 ^13.1 Puschendorf, M et al. (2008) PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat. Genet. 40 411-20 PubMed GONUTS page

[PMID:28596365-1] Almeida, M et al. (2017) PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Science 356 1081-1084 PubMed GONUTS page

[PMID:23486062-2] 2.0 ^2.1 Yokobayashi, S et al. (2013) PRC1 coordinates timing of sexual differentiation of female primordial germ cells. Nature 495 236-40 PubMed GONUTS page

[PMID:24034696-3] 3.0 ^3.1 Frangini, A et al. (2013) The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 51 647-61 PubMed GONUTS page

[PMID:16359901-4] 4.0 ^4.1 ^4.2 ^4.3 Cao, R et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20 845-54 PubMed GONUTS page

[PMID:16624538-5] Lorente, M et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech. Dev. 123 312-20 PubMed GONUTS page

[PMID:12183370-6] 6.0 ^6.1 ^6.2 Suzuki, M et al. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129 4171-83 PubMed GONUTS page

[PMID:15525528-7] 7.0 ^7.1 de Napoles, M et al. (2004) Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev. Cell 7 663-76 PubMed GONUTS page

[PMID:22770845-8] Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page

[PMID:14557078-9] Kaneko, T et al. (2003) The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Gene 315 183-92 PubMed GONUTS page

[PMID:16687444-10] 10.0 ^10.1 Fujimura, Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133 2371-81 PubMed GONUTS page

[PMID:15741318-11] Isono, K et al. (2005) Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 19 536-41 PubMed GONUTS page

[PMID:12589020-12] 12.0 ^12.1 Voncken, JW et al. (2003) Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc. Natl. Acad. Sci. U.S.A. 100 2468-73 PubMed GONUTS page

[PMID:18311137-13] 13.0 ^13.1 Puschendorf, M et al. (2008) PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat. Genet. 40 411-20 PubMed GONUTS page

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MOUSE:RING2

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