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PMID:16624538
| Citation |
Lorente, M, Pérez, C, Sánchez, C, Donohoe, M, Shi, Y and Vidal, M (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech. Dev. 123:312-20 |
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| Abstract |
Polycomb group (PcG) proteins participate in the maintenance of transcriptionally repressed state of genes relevant to cell differentiation. Here, we show anterior homeotic transformations of the axial skeleton of YY1(+/-) mice. We find that the penetrance of some of these alterations was reduced in mice that are deficient in the class II PcG gene Ring1/Ring1A, indicating a genetic interaction between those two genes. Further support for this interaction is an abnormal anterior eye formation in Ring1-deficient mice, which is enhanced in compound YY1(+/-)Ring1(-/-) mice. In addition, YY1 forms complexes with Ring1 and other class II PcG proteins such as Rnf2 and Bmi1 in GST pull down experiments in transfected cells. These findings provide evidence for a PcG function for YY1 in vertebrates. |
| Links |
PubMed Online version:10.1016/j.mod.2006.02.003 |
| Keywords |
Animals; Anterior Eye Segment/abnormalities; Bone Development/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Female; Gene Expression Regulation, Developmental; Genes, Homeobox; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Musculoskeletal Abnormalities/genetics; Mutation; Pregnancy; Repressor Proteins/physiology; Spine/abnormalities; YY1 Transcription Factor/genetics; YY1 Transcription Factor/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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