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CAEEL:CUL2

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) cul-2
Protein Name(s) Cullin-2

CUL-2

External Links
UniProt Q17390
EMBL U58084
Z92822
Z92822
Z92822
Z92822
PIR C88618
T27884
RefSeq NP_001023007.1
NP_001023008.1
NP_001023009.1
NP_499825.3
UniGene Cel.21341
ProteinModelPortal Q17390
SMR Q17390
BioGrid 41972
IntAct Q17390
MINT MINT-4507382
PaxDb Q17390
PRIDE Q17390
EnsemblMetazoa ZK520.4a
GeneID 176806
KEGG cel:CELE_ZK520.4
UCSC ZK520.4a
CTD 176806
WormBase ZK520.4a
ZK520.4b
ZK520.4c
ZK520.4d
eggNOG COG5647
GeneTree ENSGT00760000119212
HOGENOM HOG000176713
InParanoid Q17390
KO K03870
OMA VMLDYVE
PhylomeDB Q17390
Reactome REACT_256147
UniPathway UPA00143
NextBio 894074
PRO PR:Q17390
Proteomes UP000001940
GO GO:0031461
GO:0005737
GO:0005634
GO:0008595
GO:0008105
GO:0030261
GO:0008054
GO:0042078
GO:0051232
GO:0007067
GO:1902104
GO:0016567
GO:0051759
Gene3D 1.10.10.10
InterPro IPR016157
IPR016158
IPR001373
IPR019559
IPR016159
IPR011991
Pfam PF00888
PF10557
SMART SM00182
SM00884
SUPFAM SSF74788
SSF75632
PROSITE PS01256
PS50069

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0016567

protein ubiquitination

PMID:18372249[1]

IDA: Inferred from Direct Assay

P

The paper associated with the PubMed ID provides information about the function and role of Cullin-2 in ubiquitination. In this paper, Figures 1-6 provide necessary information and results that are important for this annotation.

complete
CACAO 10690

GO:0005515

protein binding

PMID:17304241[2]

IPI: Inferred from Physical Interaction

UniProtKB:P21541

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17304241[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q2WF59

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17304241[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q9BKS1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17609115[3]

IPI: Inferred from Physical Interaction

UniProtKB:P21541

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17609115[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q2WF59

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17609115[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9BKS1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20978077[4]

IPI: Inferred from Physical Interaction

WB:WBGene00018016

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:10587644[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:10587644[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001373
InterPro:IPR016157
InterPro:IPR019559

P

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0008054

negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation

PMID:15215209[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008105

asymmetric protein localization

PMID:15215209[6]

IGI: Inferred from Genetic Interaction

WB:WBGene00001284

P

Seeded From UniProt

complete

GO:0008105

asymmetric protein localization

PMID:15215209[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:15215209[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016567

protein ubiquitination

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00143

P

Seeded From UniProt

complete

GO:0019100

male germ-line sex determination

PMID:17609115[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0019102

male somatic sex determination

PMID:17609115[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030261

chromosome condensation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0226

P

Seeded From UniProt

complete

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016157
InterPro:IPR019559

C

Seeded From UniProt

complete

GO:0031462

Cul2-RING ubiquitin ligase complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000939848

C

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001373
InterPro:IPR016157
InterPro:IPR019559

F

Seeded From UniProt

complete

GO:0036369

transcription factor catabolic process

PMID:17609115[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0036369

transcription factor catabolic process

PMID:17609115[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042078

germ-line stem cell division

PMID:15215209[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145130

P

Seeded From UniProt

complete

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000231993

P

Seeded From UniProt

complete

GO:0051232

meiotic spindle elongation

PMID:15215209[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

GO:0051759

sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation

PMID:15215209[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145130

P

Seeded From UniProt

complete

GO:1902104

positive regulation of metaphase/anaphase transition of meiotic cell cycle

PMID:15215209[6]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145130

P

Seeded From UniProt

complete

contributes_to

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000231993

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Maeda, Y et al. (2008) CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. J. Biol. Chem. 283 16084-92 PubMed GONUTS page
  2. 2.0 2.1 2.2 Vasudevan, S et al. (2007) The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. EMBO Rep. 8 279-86 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Starostina, NG et al. (2007) A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev. Cell 13 127-39 PubMed GONUTS page
  4. Merlet, J et al. (2010) The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development. Development 137 3857-66 PubMed GONUTS page
  5. 5.0 5.1 Feng, H et al. (1999) CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat. Cell Biol. 1 486-92 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Liu, J et al. (2004) CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans. Development 131 3513-25 PubMed GONUTS page