CAEEL:CUL2

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	cul-2
Protein Name(s)	Cullin-2 CUL-2
External Links
UniProt	Q17390
EMBL	U58084 Z92822 Z92822 Z92822 Z92822
PIR	C88618 T27884
RefSeq	NP_001023007.1 NP_001023008.1 NP_001023009.1 NP_499825.3
UniGene	Cel.21341
ProteinModelPortal	Q17390
SMR	Q17390
BioGrid	41972
IntAct	Q17390
MINT	MINT-4507382
PaxDb	Q17390
PRIDE	Q17390
EnsemblMetazoa	ZK520.4a
GeneID	176806
KEGG	cel:CELE_ZK520.4
UCSC	ZK520.4a
CTD	176806
WormBase	ZK520.4a ZK520.4b ZK520.4c ZK520.4d
eggNOG	COG5647
GeneTree	ENSGT00760000119212
HOGENOM	HOG000176713
InParanoid	Q17390
KO	K03870
OMA	VMLDYVE
PhylomeDB	Q17390
Reactome	REACT_256147
UniPathway	UPA00143
NextBio	894074
PRO	PR:Q17390
Proteomes	UP000001940
GO	GO:0031461 GO:0005737 GO:0005634 GO:0008595 GO:0008105 GO:0030261 GO:0008054 GO:0042078 GO:0051232 GO:0007067 GO:1902104 GO:0016567 GO:0051759
Gene3D	1.10.10.10
InterPro	IPR016157 IPR016158 IPR001373 IPR019559 IPR016159 IPR011991
Pfam	PF00888 PF10557
SMART	SM00182 SM00884
SUPFAM	SSF74788 SSF75632
PROSITE	PS01256 PS50069

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016567	protein ubiquitination	PMID:18372249^[1]	ECO:0000314			P		The paper associated with the PubMed ID provides information about the function and role of Cullin-2 in ubiquitination. In this paper, Figures 1-6 provide necessary information and results that are important for this annotation.	complete CACAO 10690
part_of	GO:0031462	Cul2-RING ubiquitin ligase complex	PMID:17304241^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036369	transcription factor catabolic process	PMID:17609115^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P34708) occurs_in:(WBbt:0005784) happens_during:(GO:0040021)\|has_direct_input(UniProtKB:P34708) occurs_in:(WBbt:0005784) happens_during:(GO:0019100)	Seeded From UniProt	complete
involved_in	GO:0036369	transcription factor catabolic process	PMID:17609115^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P34708) occurs_in:(WBbt:0005772) happens_during:(GO:0019102)\|has_direct_input(UniProtKB:P34708) occurs_in:(WBbt:0005772) happens_during:(GO:0042001) happens_during:(WBls:0000038)	Seeded From UniProt	complete
involved_in	GO:0019102	male somatic sex determination	PMID:17609115^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019100	male germ-line sex determination	PMID:17609115^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902104	positive regulation of metaphase/anaphase transition of meiotic cell cycle	PMID:15215209^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00145130	P		Seeded From UniProt	complete
involved_in	GO:0051759	sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation	PMID:15215209^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00145130	P		Seeded From UniProt	complete
involved_in	GO:0051232	meiotic spindle elongation	PMID:15215209^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042078	germ-line stem cell division	PMID:15215209^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00145130	P		Seeded From UniProt	complete
involved_in	GO:0008595	anterior/posterior axis specification, embryo	PMID:15215209^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:15215209^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00001284	P		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:15215209^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031145	anaphase-promoting complex-dependent catabolic process	PMID:15215209^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10587644^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10587644^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 SGD:S000002290	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261268 MGI:MGI:1347360 MGI:MGI:1349658 MGI:MGI:1914487 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q13618 UniProtKB:Q13619 UniProtKB:Q5AJB7 WB:WBGene00000837 WB:WBGene00000839	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 FB:FBgn0032956 FB:FBgn0033260 FB:FBgn0039632 FB:FBgn0261268 PANTHER:PTN000231993 UniProtKB:Q13617 UniProtKB:Q93034	F		Seeded From UniProt	complete
part_of	GO:0031462	Cul2-RING ubiquitin ligase complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0032956 MGI:MGI:1918995 PANTHER:PTN000939848 UniProtKB:Q13617	C		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000231993 UniProtKB:Q13616 UniProtKB:Q57UJ3	C		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 UniProtKB:Q5AJB7	P		Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015509 MGI:MGI:1349658 PANTHER:PTN000231993 PomBase:SPAC17G6.12 SGD:S000002290 UniProtKB:Q13616 dictyBase:DDB_G0291972	C		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914487 PANTHER:PTN000231993 SGD:S000002290 SGD:S000003235 UniProtKB:Q13618 UniProtKB:Q57UJ3	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	P		Seeded From UniProt	complete
part_of	GO:0031461	cullin-RING ubiquitin ligase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016157	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001373 InterPro:IPR016157	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030261	chromosome condensation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0226	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Maeda, Y et al. (2008) CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. J. Biol. Chem. 283 16084-92 PubMed GONUTS page
↑ Vasudevan, S et al. (2007) The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. EMBO Rep. 8 279-86 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Starostina, NG et al. (2007) A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev. Cell 13 127-39 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Liu, J et al. (2004) CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans. Development 131 3513-25 PubMed GONUTS page
↑ ^5.0 ^5.1 Feng, H et al. (1999) CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat. Cell Biol. 1 486-92 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18372249-1] Maeda, Y et al. (2008) CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. J. Biol. Chem. 283 16084-92 PubMed GONUTS page

[PMID:17304241-2] Vasudevan, S et al. (2007) The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. EMBO Rep. 8 279-86 PubMed GONUTS page

[PMID:17609115-3] 3.0 ^3.1 ^3.2 ^3.3 Starostina, NG et al. (2007) A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev. Cell 13 127-39 PubMed GONUTS page

[PMID:15215209-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Liu, J et al. (2004) CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans. Development 131 3513-25 PubMed GONUTS page

[PMID:10587644-5] 5.0 ^5.1 Feng, H et al. (1999) CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat. Cell Biol. 1 486-92 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:CUL2

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