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HUMAN:LIN41

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRIM71 (synonyms: LIN41)
Protein Name(s) E3 ubiquitin-protein ligase TRIM71

Protein lin-41 homolog Tripartite motif-containing protein 71

External Links
UniProt Q2Q1W2
EMBL DQ232881
CCDS CCDS43060.1
RefSeq NP_001034200.1
UniGene Hs.567678
ProteinModelPortal Q2Q1W2
SMR Q2Q1W2
BioGrid 126279
STRING 9606.ENSP00000373272
PhosphoSite Q2Q1W2
DMDM 121941685
MaxQB Q2Q1W2
PaxDb Q2Q1W2
PRIDE Q2Q1W2
Ensembl ENST00000383763
GeneID 131405
KEGG hsa:131405
UCSC uc003cff.3
CTD 131405
GeneCards GC03P032859
HGNC HGNC:32669
HPA HPA038141
HPA038142
neXtProt NX_Q2Q1W2
PharmGKB PA144596246
eggNOG COG3391
GeneTree ENSGT00550000074377
HOGENOM HOG000006755
HOVERGEN HBG081916
InParanoid Q2Q1W2
KO K12035
OMA PETDFQI
OrthoDB EOG7HB58K
PhylomeDB Q2Q1W2
TreeFam TF331018
UniPathway UPA00143
GenomeRNAi 131405
NextBio 82904
PRO PR:Q2Q1W2
Proteomes UP000005640
Bgee Q2Q1W2
CleanEx HS_TRIM71
Genevestigator Q2Q1W2
GO GO:0000932
GO:0016874
GO:0035198
GO:0004842
GO:0008270
GO:0008543
GO:0000082
GO:0010586
GO:0035278
GO:0001843
GO:0021915
GO:2000637
GO:0051865
GO:0060964
GO:2000177
GO:0072089
Gene3D 2.120.10.30
2.60.40.10
3.30.40.10
4.10.45.10
InterPro IPR011042
IPR017868
IPR001298
IPR013783
IPR014756
IPR001258
IPR013017
IPR000315
IPR001841
IPR013083
IPR017907
Pfam PF00630
PF01436
PF00643
SMART SM00336
SM00557
SM00184
SUPFAM SSF81296
PROSITE PS50194
PS51125
PS50119
PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030371

translation repressor activity

PMID:23125361[1]

ECO:0000314

F

Figure 2 shows how TRIM71 is a repressor of mRNA function. Specifically 2f and 2g shows repression through use of plasmids

complete
CACAO 5664

GO:0006417

regulation of translation

PMID:23125361[1]

ECO:0000314

P


Figure 2 shows how TRIM71 is a repressor of mRNA function. Specifically 2f shows regulations through use of plasmids. In this instance, this is regulation through repression.

complete
CACAO 5668

GO:0017148

negative regulation of translation

PMID:23125361[1]

ECO:0000314

P

Figure 2 shows how TRIM71 is a repressor of mRNA function. Specifically 2f and 2g shows repression through use of plasmids. Negative regulation is brought upon by repression of mRNAs

complete
CACAO 5669

GO:0061157

mRNA destabilization

PMID:23125361[1]

ECO:0000314

P

Figure 2 data shows a decrease in mRNA abundance due to accelerated mRNA decay. Specifically 2c shows the degradation of mRNA.

complete
CACAO 5670

GO:0061158

3'-UTR-mediated mRNA destabilization

PMID:23125361[1]

ECO:0000314

P

Figure 2 collectively shows the data indicates that TRIM71 associates with 3′UTRs of many mRNAs and this decreases the number of mRNAs due to accelerated mRNA decay. Specifically 2c.

complete
CACAO 5671

enables

GO:0035198

miRNA binding

PMID:28431233[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:23125361[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0035196

production of miRNAs involved in gene silencing by miRNA

PMID:28431233[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010608

posttranscriptional regulation of gene expression

PMID:28431233[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061158

3'-UTR-mediated mRNA destabilization

PMID:23125361[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0017148

negative regulation of translation

PMID:23125361[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030371

translation repressor activity

PMID:23125361[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000177

regulation of neural precursor cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

involved_in

GO:0072089

stem cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

involved_in

GO:0060964

regulation of gene silencing by miRNA

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

involved_in

GO:0035278

miRNA mediated inhibition of translation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

enables

GO:0035198

miRNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

F

Seeded From UniProt

complete

involved_in

GO:0021915

neural tube development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

involved_in

GO:0010586

miRNA metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

C

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q1PSW8

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1860040
MGI:MGI:1933163
MGI:MGI:2145264
MGI:MGI:2685973
PANTHER:PTN001188366

F

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001188366
UniProtKB:Q6VVB1

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001188366
UniProtKB:Q6VVB1

P

Seeded From UniProt

complete

involved_in

GO:2000637

positive regulation of gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:2000177

regulation of neural precursor cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:0072089

stem cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:0071310

cellular response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

F

Seeded From UniProt

complete

involved_in

GO:0060964

regulation of gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:0051246

regulation of protein metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:0035278

miRNA mediated inhibition of translation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

enables

GO:0035198

miRNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

F

Seeded From UniProt

complete

involved_in

GO:0021915

neural tube development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:0010586

miRNA metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

F

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

C

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q1PSW8
ensembl:ENSMUSP00000107447

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000315

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0031047

gene silencing by RNA

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0230

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Loedige, I et al. (2013) The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 41 518-32 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Treiber, T et al. (2017) A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol. Cell 66 270-284.e13 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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