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MOUSE:LIN41
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Trim71 (synonyms: Gm1127, Lin41) | |
| Protein Name(s) | E3 ubiquitin-protein ligase TRIM71
Protein lin-41 homolog mLin41 Tripartite motif-containing protein 71 | |
| External Links | ||
| UniProt | Q1PSW8 | |
| EMBL | DQ005956 | |
| CCDS | CCDS40793.1 | |
| RefSeq | NP_001035968.1 | |
| UniGene | Mm.17857 | |
| ProteinModelPortal | Q1PSW8 | |
| SMR | Q1PSW8 | |
| BioGrid | 561929 | |
| STRING | 10090.ENSMUSP00000107447 | |
| PhosphoSite | Q1PSW8 | |
| PRIDE | Q1PSW8 | |
| Ensembl | ENSMUST00000111816 | |
| GeneID | 636931 | |
| KEGG | mmu:636931 | |
| UCSC | uc009rxp.1 | |
| CTD | 131405 | |
| MGI | MGI:2685973 | |
| eggNOG | COG3391 | |
| GeneTree | ENSGT00550000074377 | |
| HOGENOM | HOG000006755 | |
| HOVERGEN | HBG081916 | |
| InParanoid | Q1PSW8 | |
| KO | K12035 | |
| OMA | PETDFQI | |
| OrthoDB | EOG7HB58K | |
| PhylomeDB | Q1PSW8 | |
| TreeFam | TF331018 | |
| UniPathway | UPA00143 | |
| NextBio | 423826 | |
| PRO | PR:Q1PSW8 | |
| Proteomes | UP000000589 | |
| Bgee | Q1PSW8 | |
| CleanEx | MM_TRIM71 | |
| Genevestigator | Q1PSW8 | |
| GO | GO:0000932 GO:0016874 GO:0035198 GO:0061630 GO:0004842 GO:0008270 GO:0071310 GO:0008543 GO:0000082 GO:0010586 GO:0035278 GO:0001843 GO:0021915 GO:2000637 GO:0051865 GO:0060964 GO:2000177 GO:0051246 GO:0072089 | |
| Gene3D | 2.120.10.30 2.60.40.10 3.30.40.10 4.10.45.10 | |
| InterPro | IPR011042 IPR017868 IPR001298 IPR013783 IPR014756 IPR001258 IPR013017 IPR000315 IPR001841 IPR013083 IPR017907 | |
| Pfam | PF00630 PF01436 PF00643 | |
| SMART | SM00336 SM00557 SM00184 | |
| SUPFAM | SSF81296 | |
| PROSITE | PS50194 PS51125 PS50119 PS00518 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0035196 |
production of miRNAs involved in gene silencing by miRNA |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000177 |
regulation of neural precursor cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072089 |
stem cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060964 |
regulation of gene silencing by miRNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035278 |
miRNA mediated inhibition of translation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035198 |
miRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021915 |
neural tube development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010586 |
miRNA metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000932 |
P-body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000932 |
P-body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000082 |
G1/S transition of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1860040 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001188366 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001188366 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000637 |
positive regulation of gene silencing by miRNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000637 |
positive regulation of gene silencing by miRNA |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071310 |
cellular response to organic substance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(MGI:MGI:2446632) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(MGI:MGI:2446632) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0061158 |
3'-UTR-mediated mRNA destabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060964 |
regulation of gene silencing by miRNA |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1890546 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051246 |
regulation of protein metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035198 |
miRNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035196 |
production of miRNAs involved in gene silencing by miRNA |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030371 |
translation repressor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0017148 |
negative regulation of translation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010608 |
posttranscriptional regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001843 |
neural tube closure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4123844 |
P |
has_participant:(EMAPA:16530) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0000932 |
P-body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000932 |
P-body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061158 |
3'-UTR-mediated mRNA destabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2Q1W2 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035198 |
miRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2Q1W2 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035196 |
production of miRNAs involved in gene silencing by miRNA |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2Q1W2 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030371 |
translation repressor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2Q1W2 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0017148 |
negative regulation of translation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2Q1W2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010608 |
posttranscriptional regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2Q1W2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000932 |
P-body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2Q1W2 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031047 |
gene silencing by RNA |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000932 |
P-body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Chen, J et al. (2012) The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 26 803-15 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chang, HM et al. (2012) Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun 3 923 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Rybak, A et al. (2009) The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat. Cell Biol. 11 1411-20 PubMed GONUTS page
- ↑ Rybak, A et al. (2008) A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat. Cell Biol. 10 987-93 PubMed GONUTS page
- ↑ Maller Schulman, BR et al. (2008) The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle 7 3935-42 PubMed GONUTS page
m
- Mammalia
- GO:0046872 ! metal ion binding
- Metazoa
- GO:0035278 ! miRNA-mediated gene silencing by inhibition of translation
- GO:0035198 ! miRNA binding
- GO:0010586 ! miRNA metabolic process
- GO:0035196 ! miRNA processing
- GO:0007275 ! multicellular organism development
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
n
p
- GO:0000932 ! P-body
- GO:2000637 ! positive regulation of miRNA-mediated gene silencing
- GO:0010608 ! post-transcriptional regulation of gene expression
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0051865 ! protein autoubiquitination
- GO:0000209 ! protein polyubiquitination
- GO:0016567 ! protein ubiquitination
r
u
