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HUMAN:CUL5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CUL5 (synonyms: VACM1)
Protein Name(s) Cullin-5

CUL-5 Vasopressin-activated calcium-mobilizing receptor 1 VACM-1

External Links
UniProt Q93034
EMBL X81882
AF017061
AF327710
AK292575
CH471065
BC063306
CCDS CCDS31668.1
RefSeq NP_003469.2
UniGene Hs.440320
PDB 3DPL
3DQV
4JGH
4N9F
PDBsum 3DPL
3DQV
4JGH
4N9F
ProteinModelPortal Q93034
SMR Q93034
BioGrid 113743
DIP DIP-43696N
IntAct Q93034
MINT MINT-1184052
STRING 9606.ENSP00000299351
PhosphoSite Q93034
DMDM 14917099
MaxQB Q93034
PaxDb Q93034
PRIDE Q93034
Ensembl ENST00000393094
ENST00000531427
GeneID 8065
KEGG hsa:8065
UCSC uc001pjv.3
CTD 8065
GeneCards GC11P107913
HGNC HGNC:2556
HPA CAB017787
HPA002185
MIM 601741
neXtProt NX_Q93034
PharmGKB PA27052
eggNOG COG5647
GeneTree ENSGT00760000119212
HOGENOM HOG000007610
HOVERGEN HBG099672
InParanoid Q93034
KO K10612
OMA GRKLQWH
OrthoDB EOG78D7JD
PhylomeDB Q93034
TreeFam TF105874
Reactome REACT_115755
REACT_75842
REACT_9453
UniPathway UPA00143
ChiTaRS CUL5
EvolutionaryTrace Q93034
GeneWiki CUL5
GenomeRNAi 8065
NextBio 30655
PRO PR:Q93034
Proteomes UP000005640
Bgee Q93034
CleanEx HS_CUL5
ExpressionAtlas Q93034
Genevestigator Q93034
GO GO:0031466
GO:0005829
GO:0005634
GO:0005886
GO:0005262
GO:0004872
GO:0031625
GO:0070588
GO:0007050
GO:0008283
GO:0051480
GO:0000082
GO:0097193
GO:0008285
GO:0016567
GO:0006970
GO:0006511
GO:0016032
Gene3D 1.10.10.10
InterPro IPR016157
IPR016158
IPR001373
IPR019559
IPR016159
IPR011991
Pfam PF00888
PF10557
SMART SM00182
SM00884
SUPFAM SSF74788
SSF75632
PROSITE PS01256
PS50069

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0031625

ubiquitin protein ligase binding

PMID:17636018[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031466

Cul5-RING ubiquitin ligase complex

PMID:17636018[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0016567

protein ubiquitination

PMID:23304509[2]

ECO:0000314

P

This paper constructs an experiment that discovers the function of Cullin-5 and its role in ubiquitination. With this, Figures 1-4 present useful and necessary information for this annotation.

complete
CACAO 10689

contributes_to

GO:0061630

ubiquitin protein ligase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000231993
SGD:S000002290

F

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261268
MGI:MGI:1347360
MGI:MGI:1349658
MGI:MGI:1914487
PANTHER:PTN000231993
PomBase:SPAC17G6.12
SGD:S000002290
UniProtKB:Q13616
UniProtKB:Q13618
UniProtKB:Q13619
UniProtKB:Q5AJB7
WB:WBGene00000837
WB:WBGene00000839

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015509
FB:FBgn0032956
FB:FBgn0033260
FB:FBgn0039632
FB:FBgn0261268
PANTHER:PTN000231993
UniProtKB:Q13617
UniProtKB:Q93034

F

Seeded From UniProt

complete

part_of

GO:0031466

Cul5-RING ubiquitin ligase complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0039632
PANTHER:PTN000939877
UniProtKB:Q93034

C

Seeded From UniProt

complete

part_of

GO:0031461

cullin-RING ubiquitin ligase complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000231993
UniProtKB:Q13616
UniProtKB:Q57UJ3

C

Seeded From UniProt

complete

involved_in

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349658
PANTHER:PTN000231993
PomBase:SPAC17G6.12
SGD:S000002290
UniProtKB:Q13616
UniProtKB:Q5AJB7

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015509
MGI:MGI:1349658
PANTHER:PTN000231993
PomBase:SPAC17G6.12
SGD:S000002290
UniProtKB:Q13616
dictyBase:DDB_G0291972

C

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914487
PANTHER:PTN000231993
SGD:S000002290
SGD:S000003235
UniProtKB:Q13618
UniProtKB:Q57UJ3

P

Seeded From UniProt

complete

part_of

GO:0031466

Cul5-RING ubiquitin ligase complex

PMID:22405651[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005262

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001373
InterPro:IPR016157

P

Seeded From UniProt

complete

part_of

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016157

C

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001373
InterPro:IPR016157

F

Seeded From UniProt

complete

involved_in

GO:0097193

intrinsic apoptotic signaling pathway

PMID:9581826[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005262

calcium channel activity

PMID:9581826[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:9581826[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

PMID:8681378[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038128

ERBB2 signaling pathway

Reactome:R-HSA-1227986

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8956040
Reactome:R-HSA-8955289
Reactome:R-HSA-8955241
Reactome:R-HSA-8952044
Reactome:R-HSA-8952039
Reactome:R-HSA-1918095
Reactome:R-HSA-180603
Reactome:R-HSA-180555
Reactome:R-HSA-180540

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

Reactome:R-HSA-1918095

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Ferguson, JE 3rd et al. (2007) ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Mol. Cell. Biol. 27 6407-19 PubMed GONUTS page
  2. ↑ Hu, CZ et al. (2012) The role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1. Biochem Res Int 2012 282648 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Tron, AE et al. (2012) The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol. Cell 46 67-78 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 North, WG et al. (1998) Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. Cancer Res. 58 1866-71 PubMed GONUTS page
  6. ↑ Kipreos, ET et al. (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85 829-39 PubMed GONUTS page
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