MOUSE:PRKN2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Park2 (synonyms: Prkn)
Protein Name(s)	E3 ubiquitin-protein ligase parkin
External Links
UniProt	Q9WVS6
EMBL	AB019558 AF250293 AF250294 AF250295 BC113204
RefSeq	NP_057903.1 XP_006523403.1
UniGene	Mm.311110
PDB	1MG8 2ZEQ 3B1L
PDBsum	1MG8 2ZEQ 3B1L
ProteinModelPortal	Q9WVS6
SMR	Q9WVS6
BioGrid	206136
IntAct	Q9WVS6
MINT	MINT-2736580
STRING	10090.ENSMUSP00000063644
PhosphoSite	Q9WVS6
PRIDE	Q9WVS6
Ensembl	ENSMUST00000191124
GeneID	50873
KEGG	mmu:50873
UCSC	uc008akj.1 uc008akk.1
CTD	5071
MGI	MGI:1355296
eggNOG	NOG278133
GeneTree	ENSGT00390000011034
HOGENOM	HOG000013184
HOVERGEN	HBG053682
InParanoid	Q9WVS6
KO	K04556
PhylomeDB	Q9WVS6
UniPathway	UPA00143
EvolutionaryTrace	Q9WVS6
NextBio	307835
PRO	PR:Q9WVS6
Proteomes	UP000000589
CleanEx	MM_PARK2
ExpressionAtlas	Q9WVS6
Genevestigator	Q9WVS6
GO	GO:0016235 GO:0030054 GO:0005737 GO:0005829 GO:0030425 GO:0005783 GO:0005794 GO:0005739 GO:0043005 GO:0005634 GO:0048471 GO:0014069 GO:0045211 GO:0043234 GO:0000151 GO:0016874 GO:0043130 GO:0061630 GO:0008270 GO:0008344 GO:0070842 GO:0044257 GO:0097237 GO:0042417 GO:0051583 GO:0007612 GO:0007626 GO:0000266 GO:0000422 GO:0007005 GO:0032232 GO:1902236 GO:1903382 GO:0033132 GO:0046676 GO:0046329 GO:0010637 GO:0043524 GO:1901215 GO:0001933 GO:0090201 GO:0070050 GO:0070997 GO:0042415 GO:0043123 GO:0090141 GO:1903378 GO:0032436 GO:1902530 GO:0043161 GO:0051865 GO:0070936 GO:0070534 GO:0070585 GO:0019538 GO:0006513 GO:0000209 GO:0016567 GO:0042787 GO:0010506 GO:1900407 GO:0010821 GO:0046928 GO:2000377 GO:0050804 GO:0006355 GO:0034976 GO:0006979 GO:0001964 GO:0001963 GO:0035249 GO:0006351 GO:0055069
InterPro	IPR003977 IPR000626 IPR029071 IPR002867
Pfam	PF01485 PF00240
PIRSF	PIRSF037880
PRINTS	PR01475
SMART	SM00647 SM00213
SUPFAM	SSF54236
PROSITE	PS50053

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031398	positive regulation of protein ubiquitination	PMID:17553932^[1]	ECO:0000314			P		Figure 4: Parkin (E3 ubiquitin-ligase) binds PICK1 protein which mediates and promotes monoubiquitination of PICK1.	complete CACAO 3587
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:19591802^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:2000097)	Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:19591802^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q02248) occurs_in:(UBERON:0001891) part_of:(GO:0043524)	Seeded From UniProt	complete
involved_in	GO:0085020	protein K6-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0070979	protein K11-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:1903382	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	PMID:17116640^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O15354	P		Seeded From UniProt	complete
involved_in	GO:1903861	positive regulation of dendrite extension	PMID:24898855^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8VCM5	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	PMID:24898855^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8VCM5	P	occurs_in:(CL:0000530)	Seeded From UniProt	complete
involved_in	GO:1900407	regulation of cellular response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0070050	neuron cellular homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0055069	zinc ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0010637	negative regulation of mitochondrial fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95TI4	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:21113145^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:21113145^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070585	protein localization to mitochondrion	PMID:23858059^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P97287) part_of:(GO:0034599)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23858059^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000530) part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	PMID:23858059^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000530) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:23858059^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q8VBV4) part_of:(GO:1903204) occurs_in:(CL:0000530) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1902530	positive regulation of protein linear polyubiquitination	PMID:23453807^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903382	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	PMID:23453807^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097237	cellular response to toxic substance	PMID:12628165^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:12628165^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000700) part_of:(GO:0097237)	Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:21376232^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044257	cellular protein catabolic process	PMID:21376232^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q3U133) occurs_in:(UBERON:0002435)\|has_input(UniProtKB:Q3U133) occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:1900407	regulation of cellular response to oxidative stress	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041100 PANTHER:PTN000188399 UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0017418 FB:FBgn0041100 MGI:MGI:1355296 PANTHER:PTN000188395 TAIR:locus:2057401 UniProtKB:O60260 UniProtKB:P50876	F		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000188399 ZFIN:ZDB-GENE-050417-109	P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1355296 PANTHER:PTN000188395	P		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0017418 FB:FBgn0041100 PANTHER:PTN000188395 UniProtKB:O60260 UniProtKB:O95376 UniProtKB:Q9Y4X5 WB:WBGene00003967	F		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041100 PANTHER:PTN000188399 UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0017418 FB:FBgn0041100 MGI:MGI:1344361 MGI:MGI:1344363 PANTHER:PTN000188395 UniProtKB:O60260 UniProtKB:O95376 UniProtKB:Q7Z419	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000188399 RGD:61797 UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000188399 UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000188399 RGD:61797 UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041100 MGI:MGI:1355296 PANTHER:PTN000188399 RGD:61797 UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0017418 FB:FBgn0041100 MGI:MGI:1355296 PANTHER:PTN000188395 RGD:61797 UniProtKB:O60260 UniProtKB:O95376 UniProtKB:Q7Z419 UniProtKB:Q9UBS8 UniProtKB:Q9Y4X5 WB:WBGene00003967 WB:WBGene00016158	C		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000188399 UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041100 PANTHER:PTN000188399 RGD:61797 UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041100 PANTHER:PTN000188395 UniProtKB:O60260 UniProtKB:O95376	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000188395 UniProtKB:O60260 WB:WBGene00003967	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000377	regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
part_of	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
enables	GO:1990444	F-box domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905477	positive regulation of protein localization to membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905366	negative regulation of intralumenal vesicle formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905232	cellular response to L-glutamate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904881	cellular response to hydrogen sulfide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904049	negative regulation of spontaneous neurotransmitter secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903599	positive regulation of autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903542	negative regulation of exosomal secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903204	negative regulation of oxidative stress-induced neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902530	positive regulation of protein linear polyubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902283	negative regulation of primary amine oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901800	positive regulation of proteasomal protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901526	positive regulation of mitophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9JK66	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900407	regulation of cellular response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099074	mitochondrion to lysosome transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
colocalizes_with	GO:0099073	mitochondrion-derived vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
part_of	GO:0097708	intracellular vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
enables	GO:0097602	cullin family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097237	cellular response to toxic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090394	negative regulation of excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090258	negative regulation of mitochondrial fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0085020	protein K6-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
colocalizes_with	GO:0071797	LUBAC complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070979	protein K11-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070842	aggresome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070585	protein localization to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:28063983^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:20064468^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:700009)	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051967	negative regulation of synaptic transmission, glutamatergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051865	protein autoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051646	mitochondrion localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051583	dopamine uptake involved in synaptic transmission	PMID:12915482^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P	occurs_in:(EMAPA:16974) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051582	positive regulation of neurotransmitter uptake	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	PMID:12930822^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681404	P	regulates_o_occurs_in:(EMAPA:17549) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	PMID:12930822^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681404	P	regulates_o_occurs_in:(EMAPA:17549) regulates_o_occurs_in:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046676	negative regulation of insulin secretion	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044828	negative regulation by host of viral genome replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044257	cellular protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043653	mitochondrial fragmentation involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043388	positive regulation of DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:11675120^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042417	dopamine metabolic process	PMID:12915482^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P	occurs_in:(EMAPA:17549)\|occurs_in:(EMAPA:16896)\|occurs_in:(EMAPA:32678)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042415	norepinephrine metabolic process	PMID:15249681^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3050230	P	occurs_in:(EMAPA:32809)\|occurs_in:(EMAPA:17577)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035249	synaptic transmission, glutamatergic	PMID:12915482^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033132	negative regulation of glucokinase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18190519^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)\|part_of:(EMAPA:16105)\|part_of:(EMAPA:35578)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032232	negative regulation of actin filament bundle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031396	regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019538	protein metabolic process	PMID:14985362^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681404	P	occurs_in:(EMAPA:16974) has_participant:(MGI:MGI:97532)\|occurs_in(EMAPA:16974) has_participant:(MGI:MGI:1915513)\|occurs_in(EMAPA:16974) has_participant:(MGI:MGI:99523)\|occurs_in(EMAPA:16974) has_participant:(MGI:MGI:109486)\|occurs_in(EMAPA:16974) has_participant:(MGI:MGI:894320)\|occurs_in(EMAPA:16974) has_participant:(MGI:MGI:95741)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010994	free ubiquitin chain polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010918	positive regulation of mitochondrial membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010821	regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010636	positive regulation of mitochondrial fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010506	regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010498	proteasomal protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:18346797^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:15882845^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:12930822^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:12915482^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:15684050^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3055212	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:12915482^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0007612	learning	PMID:15684050^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3055212	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006513	protein monoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24187134^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24187134^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001964	startle response	PMID:15249681^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3050230	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001963	synaptic transmission, dopaminergic	PMID:12915482^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2678247	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000423	mitophagy	PMID:24949970^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1921624	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000422	autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000422	autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000209	protein polyubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61797	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60260	P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
enables	GO:1990444	F-box domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:1905477	positive regulation of protein localization to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1905366	negative regulation of intralumenal vesicle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1904049	negative regulation of spontaneous neurotransmitter secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1903599	positive regulation of autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1903542	negative regulation of exosomal secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1902530	positive regulation of protein linear polyubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1902283	negative regulation of primary amine oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1901800	positive regulation of proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:1900407	regulation of cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0099074	mitochondrion to lysosome transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0099073	mitochondrion-derived vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
involved_in	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0097602	cullin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0097237	cellular response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0085020	protein K6-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0071797	LUBAC complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
involved_in	GO:0070979	protein K11-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0070842	aggresome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0051582	positive regulation of neurotransmitter uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0044828	negative regulation by host of viral genome replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0044257	cellular protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0033132	negative regulation of glucokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0032232	negative regulation of actin filament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0031396	regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0010994	free ubiquitin chain polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0010636	positive regulation of mitochondrial fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0010498	proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	F		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60260 ensembl:ENSP00000355865	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:X5DR79 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:X5DR79 ensembl:ENSP00000355865	C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003977 InterPro:IPR031127	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003977	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003977	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031127	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Joch, M et al. (2007) Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol. Biol. Cell 18 3105-18 PubMed GONUTS page
↑ ^2.0 ^2.1 Rawal, N et al. (2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388 473-8 PubMed GONUTS page
↑ Kitao, Y et al. (2007) Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum. Mol. Genet. 16 50-60 PubMed GONUTS page
↑ ^4.0 ^4.1 Yun, J et al. (2014) MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife 3 e01958 PubMed GONUTS page
↑ ^5.0 ^5.1 Bouman, L et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 18 769-82 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page
↑ ^7.0 ^7.1 Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page
↑ ^8.0 ^8.1 Staropoli, JF et al. (2003) Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37 735-49 PubMed GONUTS page
↑ ^9.0 ^9.1 Shin, JH et al. (2011) PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell 144 689-702 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Upadhyay, M et al. (2017) Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiol. Dis. 100 39-51 PubMed GONUTS page
↑ Trempe, JF et al. (2009) SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol. Cell 36 1034-47 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Itier, JM et al. (2003) Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum. Mol. Genet. 12 2277-91 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Goldberg, MS et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278 43628-35 PubMed GONUTS page
↑ Huynh, DP et al. (2001) Differential expression and tissue distribution of parkin isoforms during mouse development. Brain Res. Dev. Brain Res. 130 173-81 PubMed GONUTS page
↑ ^16.0 ^16.1 Von Coelln, R et al. (2004) Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc. Natl. Acad. Sci. U.S.A. 101 10744-9 PubMed GONUTS page
↑ Van Humbeeck, C et al. (2008) Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain. Eur. J. Neurosci. 27 284-93 PubMed GONUTS page
↑ Palacino, JJ et al. (2004) Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J. Biol. Chem. 279 18614-22 PubMed GONUTS page
↑ Navarro, P et al. (2008) Memory and exploratory impairment in mice that lack the Park-2 gene and that over-express the human FTDP-17 mutant Tau. Behav. Brain Res. 189 350-6 PubMed GONUTS page
↑ González, S et al. (2005) Cannabinoid CB(1) receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice. Brain Res. 1046 195-206 PubMed GONUTS page
↑ ^21.0 ^21.1 Perez, FA & Palmiter, RD (2005) Parkin-deficient mice are not a robust model of parkinsonism. Proc. Natl. Acad. Sci. U.S.A. 102 2174-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Hofmeister-Brix, A et al. (2013) Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. J. Biol. Chem. 288 35824-39 PubMed GONUTS page
↑ Soleimanpour, SA et al. (2014) The diabetes susceptibility gene Clec16a regulates mitophagy. Cell 157 1577-90 PubMed GONUTS page

[PMID:17553932-1] Joch, M et al. (2007) Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol. Biol. Cell 18 3105-18 PubMed GONUTS page

[PMID:19591802-2] 2.0 ^2.1 Rawal, N et al. (2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388 473-8 PubMed GONUTS page

[PMID:17116640-3] Kitao, Y et al. (2007) Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum. Mol. Genet. 16 50-60 PubMed GONUTS page

[PMID:24898855-4] 4.0 ^4.1 Yun, J et al. (2014) MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife 3 e01958 PubMed GONUTS page

[PMID:21113145-5] 5.0 ^5.1 Bouman, L et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 18 769-82 PubMed GONUTS page

[PMID:23858059-6] 6.0 ^6.1 ^6.2 ^6.3 Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page

[PMID:23453807-7] 7.0 ^7.1 Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page

[PMID:12628165-8] 8.0 ^8.1 Staropoli, JF et al. (2003) Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37 735-49 PubMed GONUTS page

[PMID:21376232-9] 9.0 ^9.1 Shin, JH et al. (2011) PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell 144 689-702 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28063983-11] Upadhyay, M et al. (2017) Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiol. Dis. 100 39-51 PubMed GONUTS page

[PMID:20064468-12] Trempe, JF et al. (2009) SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol. Cell 36 1034-47 PubMed GONUTS page

[PMID:12915482-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Itier, JM et al. (2003) Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum. Mol. Genet. 12 2277-91 PubMed GONUTS page

[PMID:12930822-14] 14.0 ^14.1 ^14.2 Goldberg, MS et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278 43628-35 PubMed GONUTS page

[PMID:11675120-15] Huynh, DP et al. (2001) Differential expression and tissue distribution of parkin isoforms during mouse development. Brain Res. Dev. Brain Res. 130 173-81 PubMed GONUTS page

[PMID:15249681-16] 16.0 ^16.1 Von Coelln, R et al. (2004) Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc. Natl. Acad. Sci. U.S.A. 101 10744-9 PubMed GONUTS page

[PMID:18190519-17] Van Humbeeck, C et al. (2008) Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain. Eur. J. Neurosci. 27 284-93 PubMed GONUTS page

[PMID:14985362-18] Palacino, JJ et al. (2004) Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J. Biol. Chem. 279 18614-22 PubMed GONUTS page

[PMID:18346797-19] Navarro, P et al. (2008) Memory and exploratory impairment in mice that lack the Park-2 gene and that over-express the human FTDP-17 mutant Tau. Behav. Brain Res. 189 350-6 PubMed GONUTS page

[PMID:15882845-20] González, S et al. (2005) Cannabinoid CB(1) receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice. Brain Res. 1046 195-206 PubMed GONUTS page

[PMID:15684050-21] 21.0 ^21.1 Perez, FA & Palmiter, RD (2005) Parkin-deficient mice are not a robust model of parkinsonism. Proc. Natl. Acad. Sci. U.S.A. 102 2174-9 PubMed GONUTS page

[PMID:24187134-22] 22.0 ^22.1 Hofmeister-Brix, A et al. (2013) Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. J. Biol. Chem. 288 35824-39 PubMed GONUTS page

[PMID:24949970-23] Soleimanpour, SA et al. (2014) The diabetes susceptibility gene Clec16a regulates mitophagy. Cell 157 1577-90 PubMed GONUTS page

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MOUSE:PRKN2

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