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Category:GO:0090201 ! negative regulation of release of cytochrome c from mitochondria

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DAG for GO:0090201id: GO:0090201

name: negative regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process.
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria
is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway
relationship: negatively_regulates: GO:0001836 ! release of cytochrome c from mitochondria
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria

AmiGO

Last version checked
releases/2017-02-26.

23:02:2017 10:01.

slaulederkind
Last updated
releases/2017-02-11

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