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MOUSE:PELI1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Peli1 | |
| Protein Name(s) | E3 ubiquitin-protein ligase pellino homolog 1
Pellino-1 RING-type E3 ubiquitin transferase pellino homolog 1 (ECO:0000305) | |
| External Links | ||
| UniProt | Q8C669 | |
| EMBL | AF302503 AK009945 AK045673 AK076458 BC016515 | |
| CCDS | CCDS24462.1 | |
| RefSeq | NP_075813.2 | |
| UniGene | Mm.28957 | |
| ProteinModelPortal | Q8C669 | |
| SMR | Q8C669 | |
| BioGrid | 212043 | |
| DIP | DIP-48336N | |
| IntAct | Q8C669 | |
| STRING | 10090.ENSMUSP00000090979 | |
| iPTMnet | Q8C669 | |
| PhosphoSitePlus | Q8C669 | |
| MaxQB | Q8C669 | |
| PaxDb | Q8C669 | |
| PRIDE | Q8C669 | |
| Ensembl | ENSMUST00000093290 ENSMUST00000101477 | |
| GeneID | 67245 | |
| KEGG | mmu:67245 | |
| UCSC | uc007idl.1 | |
| CTD | 57162 | |
| MGI | MGI:1914495 | |
| eggNOG | KOG3842 ENOG410XP3S | |
| GeneTree | ENSGT00390000007680 | |
| HOGENOM | HOG000234110 | |
| HOVERGEN | HBG053559 | |
| InParanoid | Q8C669 | |
| KO | K11964 | |
| OMA | SGEQGYI | |
| OrthoDB | EOG091G0631 | |
| PhylomeDB | Q8C669 | |
| TreeFam | TF314338 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-446652 R-MMU-446652] [www.reactome.org/content/detail/R-MMU-937039 R-MMU-937039] [www.reactome.org/content/detail/R-MMU-975144 R-MMU-975144] | |
| UniPathway | UPA00143 | |
| ChiTaRS | Peli1 | |
| PRO | PR:Q8C669 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000020134 | |
| CleanEx | MM_PELI1 | |
| ExpressionAtlas | Q8C669 | |
| Genevisible | Q8C669 | |
| GO | GO:0005634 GO:0061630 GO:0004842 GO:0032088 GO:0050868 GO:0042130 GO:0050871 GO:0030890 GO:0001819 GO:0043123 GO:0031398 GO:0034141 GO:0034145 GO:0070936 GO:0000209 GO:0043331 GO:0032496 GO:0008063 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR006800 IPR013083 | |
| PANTHER | PTHR12098 | |
| Pfam | PF04710 | |
| PIRSF | PIRSF038886 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0051306 |
mitotic sister chromatid separation |
ECO:0000315 |
P |
The metaphase chromosome-spreading assay revealed that premature sister chromatid separation (PMSCS), a hallmark of a defective mitotic checkpoint [19, 25], was observed in approximately 18 ± 1.7% of splenocytes isolated from Peli1-Tg mice but in < 5% of control splenocytes (Figure 1B), by author. Protein: E3 ubiquitin-protein ligase pellino homolog 1 Organism: mouse |
complete | |||||
| GO:0048536 |
spleen development |
ECO:0000315 |
P |
Protien: E3 ubiquitin-protein ligase pellino homolog 1 Organism: Mouse splenocytes were isolated from Peli1-Tg mice that displayed splenic plasmacytoid differentiation and lymphomas, and from control littermate non-Tg mice that had normal splenic features (Figure 1A, 1B) by author. |
complete | |||||
| GO:0000778 |
condensed nuclear chromosome kinetochore |
ECO:0000314 |
C |
Protein: E3 ubiquitin-protein ligase pellino homolog 1 Organism: Mouse Immunofluorescence analyses revealed localization of Peli1 at spindle poles and kinetochores (Figure 2A). |
complete | |||||
| GO:1905558 |
negative regulation of mitotic nuclear envelope disassembly |
ECO:0000314 |
P |
Organism: mouse Protein:E3 ubiquitin-protein ligase pellino homolog 1 Peli1 overexpressing cells showed severe delays in the metaphase-to-anaphase transition compared to control cells. (B) Average time from mitotic onset (nuclear envelope breakdown) to anaphase of Peli1 overexpressing cells or control cells (control cells, n = 24; Myc-Peli1-transfected cells, n = 20). |
complete | |||||
|
involved_in |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060546 |
negative regulation of necroptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914495 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914495 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008063 |
Toll signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0025574 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914495 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(MGI:MGI:108212) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060546 |
negative regulation of necroptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050871 |
positive regulation of B cell activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050868 |
negative regulation of T cell activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
regulates_o_occurs_in:(CL:0000084) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0043331 |
response to dsRNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0034145 |
positive regulation of toll-like receptor 4 signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0034141 |
positive regulation of toll-like receptor 3 signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
regulates_o_occurs_in:(CL:0000084) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030890 |
positive regulation of B cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000084) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001819 |
positive regulation of cytokine production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0000209 |
protein polyubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4361448 |
P |
occurs_in:(CL:0000084) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96FA3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070534 |
protein K63-linked ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96FA3 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96FA3 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060546 |
negative regulation of necroptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96FA3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96FA3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96FA3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008592 |
regulation of Toll signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Park, J et al. (2017) Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation. Oncotarget PubMed GONUTS page
- ↑ Choi, SW et al. (2018) PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol. Cell 70 920-935.e7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Chang, M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat. Immunol. 12 1002-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page
g
m
n
- GO:0042130 ! negative regulation of T cell proliferation
- GO:1905558 ! negative regulation of mitotic nuclear envelope disassembly
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:0060546 ! negative regulation of necroptotic process
- GO:0050868 ! negative regulation of T cell activation
- GO:0005634 ! nucleus
p
- GO:0050871 ! positive regulation of B cell activation
- GO:0034141 ! positive regulation of toll-like receptor 3 signaling pathway
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0034145 ! positive regulation of toll-like receptor 4 signaling pathway
- GO:0031398 ! positive regulation of protein ubiquitination
- GO:0001819 ! positive regulation of cytokine production
- GO:0030890 ! positive regulation of B cell proliferation
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0070936 ! protein K48-linked ubiquitination
- GO:0070534 ! protein K63-linked ubiquitination
- GO:0000209 ! protein polyubiquitination
- GO:0016567 ! protein ubiquitination
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