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HUMAN:B4DJT4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SKP2
Protein Name(s) S-phase kinase-associated protein 2

cDNA FLJ60606, highly similar to S-phase kinase-associated protein 2

External Links
UniProt B4DJT4
EMBL AC008942
AK296223
IPI IPI01012086
RefSeq NP_001230049.1
NP_005974.2
UniGene Hs.23348
ProteinModelPortal B4DJT4
SMR B4DJT4
STRING B4DJT4
DNASU 6502
Ensembl ENST00000546211
GeneID 6502
KEGG hsa:6502
UCSC uc011cou.2
CTD 6502
HGNC HGNC:10901
GeneTree ENSGT00390000007918
HOVERGEN HBG047488
KO K03875
NextBio 25275
Bgee B4DJT4
GO GO:0016301
InterPro IPR001611
Pfam PF00560

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070936

protein K48-linked ubiquitination

PMID:27194766[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:27194766[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:27194766[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:27194766[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:16880511[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0061630

ubiquitin protein ligase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1351663
PANTHER:PTN001923412

F

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1351663
PANTHER:PTN002364414

P

Seeded From UniProt

complete

involved_in

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1354702
PANTHER:PTN001923412
PomBase:SPCC338.16
SGD:S000005606
TAIR:locus:2061136
UniProtKB:Q9UKT7

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037236
MGI:MGI:1351663
MGI:MGI:2442921
PANTHER:PTN001923412
RGD:1311830
SGD:S000005606
TAIR:locus:2099237
TAIR:locus:2174398
UniProtKB:Q13309
UniProtKB:Q9UKT7

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002364414
UniProtKB:Q13309

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002364414
UniProtKB:Q13309

C

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1351663
PANTHER:PTN002364414

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:23277542[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22770219[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13309

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071460

cellular response to cell-matrix adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2GUZ0
ensembl:ENSRNOP00000074788

P

Seeded From UniProt

complete

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2GUZ0
ensembl:ENSRNOP00000074788

P

Seeded From UniProt

complete

involved_in

GO:1902916

positive regulation of protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

P

Seeded From UniProt

complete

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

F

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

P

Seeded From UniProt

complete

involved_in

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

C

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

P

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

P

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0Z3
ensembl:ENSMUSP00000094225

P

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

PMID:7553852[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

Reactome:R-HSA-5688426

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-983157
Reactome:R-HSA-983156
Reactome:R-HSA-983147
Reactome:R-HSA-983140
Reactome:R-HSA-8956200
Reactome:R-HSA-8956040
Reactome:R-HSA-8955289
Reactome:R-HSA-8955241
Reactome:R-HSA-8952620
Reactome:R-HSA-8952618
Reactome:R-HSA-188191

ECO:0000304

author statement supported by traceable reference used in manual assertion











C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8939706
Reactome:R-HSA-8939688
Reactome:R-HSA-68946
Reactome:R-HSA-6781922
Reactome:R-HSA-187575
Reactome:R-HSA-187574
Reactome:R-HSA-187552
Reactome:R-HSA-187545
Reactome:R-HSA-1363331
Reactome:R-HSA-1363328

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

Reactome:R-HSA-983168

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Xue, B et al. (2016) ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway. J. Virol. 90 6832-45 PubMed GONUTS page
  2. Sabile, A et al. (2006) Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol. Cell. Biol. 26 5994-6004 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Zhang, Q et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 110 978-83 PubMed GONUTS page
  5. Inuzuka, H et al. (2012) Acetylation-dependent regulation of Skp2 function. Cell 150 179-93 PubMed GONUTS page
  6. Zhang, H et al. (1995) p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82 915-25 PubMed GONUTS page