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HUMAN:B4DJT4
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | SKP2 | |
Protein Name(s) | S-phase kinase-associated protein 2
cDNA FLJ60606, highly similar to S-phase kinase-associated protein 2 | |
External Links | ||
UniProt | B4DJT4 | |
EMBL | AC008942 AK296223 | |
IPI | IPI01012086 | |
RefSeq | NP_001230049.1 NP_005974.2 | |
UniGene | Hs.23348 | |
ProteinModelPortal | B4DJT4 | |
SMR | B4DJT4 | |
STRING | B4DJT4 | |
DNASU | 6502 | |
Ensembl | ENST00000546211 | |
GeneID | 6502 | |
KEGG | hsa:6502 | |
UCSC | uc011cou.2 | |
CTD | 6502 | |
HGNC | HGNC:10901 | |
GeneTree | ENSGT00390000007918 | |
HOVERGEN | HBG047488 | |
KO | K03875 | |
NextBio | 25275 | |
Bgee | B4DJT4 | |
GO | GO:0016301 | |
InterPro | IPR001611 | |
Pfam | PF00560 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0070936 |
protein K48-linked ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1351663 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1351663 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031146 |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1354702 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037236 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002364414 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002364414 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000086 |
G2/M transition of mitotic cell cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1351663 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071460 |
cellular response to cell-matrix adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2GUZ0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B2GUZ0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902916 |
positive regulation of protein polyubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033148 |
positive regulation of intracellular estrogen receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000086 |
G2/M transition of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000082 |
G1/S transition of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0Z3 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000082 |
G1/S transition of mitotic cell cycle |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016579 |
protein deubiquitination |
Reactome:R-HSA-5688426 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-983157 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8939706 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0000209 |
protein polyubiquitination |
Reactome:R-HSA-983168 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Xue, B et al. (2016) ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway. J. Virol. 90 6832-45 PubMed GONUTS page
- ↑ Sabile, A et al. (2006) Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol. Cell. Biol. 26 5994-6004 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Zhang, Q et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 110 978-83 PubMed GONUTS page
- ↑ Inuzuka, H et al. (2012) Acetylation-dependent regulation of Skp2 function. Cell 150 179-93 PubMed GONUTS page
- ↑ Zhang, H et al. (1995) p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82 915-25 PubMed GONUTS page
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- GO:0033148 ! positive regulation of intracellular estrogen receptor signaling pathway
- GO:1902916 ! positive regulation of protein polyubiquitination
- GO:0048661 ! positive regulation of smooth muscle cell proliferation
- GO:0043687 ! post-translational protein modification
- Primates
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0016579 ! protein deubiquitination
- GO:0070936 ! protein K48-linked ubiquitination
- GO:0000209 ! protein polyubiquitination
- GO:0016567 ! protein ubiquitination
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