HUMAN:RAD18

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RAD18 (synonyms: RNF73)
Protein Name(s)	E3 ubiquitin-protein ligase RAD18 Postreplication repair protein RAD18 hHR18 hRAD18 RING finger protein 73
External Links
UniProt	Q9NS91
EMBL	AB035274 AF169796 AY004333 AK023075 AY961989 AC008151 AC034186 BC001302
CCDS	CCDS2571.1
RefSeq	NP_064550.3
UniGene	Hs.375684
PDB	2MRE 2MRF 2Y43 2YBF
PDBsum	2MRE 2MRF 2Y43 2YBF
ProteinModelPortal	Q9NS91
SMR	Q9NS91
BioGrid	121212
DIP	DIP-29831N
IntAct	Q9NS91
MINT	MINT-3073564
STRING	9606.ENSP00000264926
PhosphoSite	Q9NS91
DMDM	313104165
MaxQB	Q9NS91
PaxDb	Q9NS91
PeptideAtlas	Q9NS91
PRIDE	Q9NS91
DNASU	56852
Ensembl	ENST00000264926
GeneID	56852
KEGG	hsa:56852
UCSC	uc003brd.3
CTD	56852
GeneCards	GC03M008896
H-InvDB	HIX0003022
HGNC	HGNC:18278
HPA	HPA006716 HPA008752
MIM	605256
neXtProt	NX_Q9NS91
PharmGKB	PA134912253
eggNOG	COG5432
GeneTree	ENSGT00390000011230
HOGENOM	HOG000234845
HOVERGEN	HBG054721
InParanoid	Q9NS91
KO	K10627
OMA	RHQEFVQ
PhylomeDB	Q9NS91
TreeFam	TF101214
UniPathway	UPA00143
GeneWiki	RAD18
GenomeRNAi	56852
NextBio	62262
PRO	PR:Q9NS91
Proteomes	UP000005640
Bgee	Q9NS91
CleanEx	HS_RAD18
ExpressionAtlas	Q9NS91
Genevestigator	Q9NS91
GO	GO:0000785 GO:0005634 GO:0005657 GO:0001741 GO:0003684 GO:0016874 GO:0031593 GO:0031625 GO:0000403 GO:0008270 GO:0006281 GO:0045910 GO:0016567 GO:0009411 GO:0007283
Gene3D	1.10.720.30 3.30.40.10
InterPro	IPR003034 IPR018957 IPR006642 IPR001841 IPR013083 IPR017907
Pfam	PF02037 PF00097
SMART	SM00184 SM00513 SM00734
PROSITE	PS50800 PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006513	protein monoubiquitination	PMID:3078399^[1]	ECO:0000316		UniProtKB:P63146	P	Figure 2 shows that Rad18 inhibits Rad6’s ubiquitin chain-formation activity to direct Rad6 toward PCNA monoubiquitination.	complete CACAO 5902
involved_in	GO:0060548	negative regulation of cell death	PMID:22036607^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:22036607^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0042405	nuclear inclusion body	PMID:22036607^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22036607^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:25931565^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051984	positive regulation of chromosome segregation	PMID:25931565^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:25931565^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:25931565^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96SB8	F	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:25931565^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IY18	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15632077^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:15632077^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:10908344^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49459	F	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18363965^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63146	F	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:10908344^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63146	F	Seeded From UniProt	complete
enables	GO:0031593	polyubiquitin modification-dependent protein binding	PMID:22742833^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:10884424^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005657	replication fork	PMID:18363965^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10884424^[8]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:10884424^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000403	Y-form DNA binding	PMID:18363965^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001020335 PomBase:SPBC1734.06	F	Seeded From UniProt	complete
enables	GO:0043142	single-stranded DNA-dependent ATPase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001020335 SGD:S000000662	F	Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890476 PANTHER:PTN001020335	P	Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001020335 SGD:S000000662	P	Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001020335 PomBase:SPBC1734.06	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890476 PANTHER:PTN001020335 SGD:S000000662 UniProtKB:Q9NS91	C	Seeded From UniProt	complete
part_of	GO:0097505	Rad6-Rad18 complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001020335 SGD:S000000662	C	Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:25023518^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25023518^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:25023518^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25023518^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006642	F	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039577	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006642	P	Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039577	P	Seeded From UniProt	complete
involved_in	GO:0006513	protein monoubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039577	P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039577	F	Seeded From UniProt	complete
involved_in	GO:0042769	DNA damage response, detection of DNA damage	Reactome:R-HSA-110314	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	Reactome:R-HSA-8866654	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8943041 Reactome:R-HSA-8943040 Reactome:R-HSA-8943007 Reactome:R-HSA-8943003 Reactome:R-HSA-5652009 Reactome:R-HSA-5652005	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Klech, H & Pohl, W (1987) [Detection of mediators in bronchoalveolar lavage]. Wien Med Wochenschr Suppl 103 56-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Liu, T et al. (2012) RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst.) 11 131-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Räschle, M et al. (2015) DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Science 348 1253671 PubMed GONUTS page
↑ ^4.0 ^4.1 Adams, DJ et al. (2005) BRCTx is a novel, highly conserved RAD18-interacting protein. Mol. Cell. Biol. 25 779-88 PubMed GONUTS page
↑ ^5.0 ^5.1 Xin, H et al. (2000) The human RAD18 gene product interacts with HHR6A and HHR6B. Nucleic Acids Res. 28 2847-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Tsuji, Y et al. (2008) Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. Genes Cells 13 343-54 PubMed GONUTS page
↑ Panier, S et al. (2012) Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol. Cell 47 383-95 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Tateishi, S et al. (2000) Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. Proc. Natl. Acad. Sci. U.S.A. 97 7927-32 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Zeman, MK et al. (2014) DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J. Cell Biol. 206 183-97 PubMed GONUTS page

[PMID:3078399-1] Klech, H & Pohl, W (1987) [Detection of mediators in bronchoalveolar lavage]. Wien Med Wochenschr Suppl 103 56-9 PubMed GONUTS page

[PMID:22036607-2] 2.0 ^2.1 ^2.2 ^2.3 Liu, T et al. (2012) RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst.) 11 131-8 PubMed GONUTS page

[PMID:25931565-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Räschle, M et al. (2015) DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Science 348 1253671 PubMed GONUTS page

[PMID:15632077-4] 4.0 ^4.1 Adams, DJ et al. (2005) BRCTx is a novel, highly conserved RAD18-interacting protein. Mol. Cell. Biol. 25 779-88 PubMed GONUTS page

[PMID:10908344-5] 5.0 ^5.1 Xin, H et al. (2000) The human RAD18 gene product interacts with HHR6A and HHR6B. Nucleic Acids Res. 28 2847-54 PubMed GONUTS page

[PMID:18363965-6] 6.0 ^6.1 ^6.2 Tsuji, Y et al. (2008) Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. Genes Cells 13 343-54 PubMed GONUTS page

[PMID:22742833-7] Panier, S et al. (2012) Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol. Cell 47 383-95 PubMed GONUTS page

[PMID:10884424-8] 8.0 ^8.1 ^8.2 Tateishi, S et al. (2000) Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. Proc. Natl. Acad. Sci. U.S.A. 97 7927-32 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25023518-10] 10.0 ^10.1 ^10.2 ^10.3 Zeman, MK et al. (2014) DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J. Cell Biol. 206 183-97 PubMed GONUTS page

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HUMAN:RAD18

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