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CAEEL:CUL4

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) cul-4
Protein Name(s) Cullin-4

CUL-4

External Links
UniProt Q17392
EMBL FO080734
U58086
PIR T16367
RefSeq NP_495525.2
UniGene Cel.15594
ProteinModelPortal Q17392
SMR Q17392
IntAct Q17392
STRING 6239.F45E12.3
PaxDb Q17392
PRIDE Q17392
EnsemblMetazoa F45E12.3
GeneID 174198
KEGG cel:CELE_F45E12.3
UCSC F45E12.3
CTD 174198
WormBase F45E12.3
eggNOG COG5647
GeneTree ENSGT00760000119212
InParanoid Q17392
KO K10609
OMA ERIFCSS
OrthoDB EOG7F24SC
PhylomeDB Q17392
UniPathway UPA00143
NextBio 882965
PRO PR:Q17392
Proteomes UP000001940
GO GO:0031461
GO:0016567
GO:0006511
Gene3D 1.10.10.10
InterPro IPR016157
IPR016158
IPR001373
IPR019559
IPR016159
IPR011991
Pfam PF00888
PF10557
SMART SM00182
SM00884
SUPFAM SSF74788
SSF75632
PROSITE PS01256
PS50069

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

incorrect (CACAO)

GO:0006275

regulation of DNA replication

PMID:18339895[1]

TAS: Traceable Author Statement

P

intro “Cul4 is important for regulating DNA replication” Discussion (pg:326) without the CUL-4 cullin… multiple rounds of DNA replication were initiated in a single cell cycle,

complete

incorrect (CACAO)

GO:0048589

developmental growth

PMID:18339895[1]

TAS: Traceable Author Statement

P

Discussion (pg:326) without the CUL-4 cullin...development arrested at the L2 larval stage..

complete

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001373
InterPro:IPR016157
InterPro:IPR019559

P

Seeded From UniProt

complete

GO:0016567

protein ubiquitination

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00143

P

Seeded From UniProt

complete

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016157
InterPro:IPR019559

C

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001373
InterPro:IPR016157
InterPro:IPR019559

F

Seeded From UniProt

complete

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000231993

P

Seeded From UniProt

complete

GO:0000003

reproduction

PMID:14551910[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00027342

P

complete

GO:0002009

morphogenesis of an epithelium

PMID:14551910[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00027342

P

complete

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:19111656[3]

IGI: Inferred from Genetic Interaction

WB:WBGene00001574

P

Seeded From UniProt

complete

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001373

P

complete

GO:0080008

Cul4-RING E3 ubiquitin ligase complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000748578

C

Seeded From UniProt

complete

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016157

P

complete

contributes_to

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000231993

F

Seeded From UniProt

complete

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016158

P

complete

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019559

P

complete

GO:0008340

determination of adult lifespan

PMID:17392428[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00078732

P

complete

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001373

C

complete

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016157

C

complete

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016158

C

complete

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019559

C

complete

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001373

F

complete

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016157

F

complete

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016158

F

complete

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019559

F

complete

GO:0040010

positive regulation of growth rate

PMID:14551910[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00025510

P

complete

GO:0040010

positive regulation of growth rate

PMID:14551910[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00027342

P

complete

GO:0040011

locomotion

PMID:14551910[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00025510

P

complete

GO:0040035

hermaphrodite genitalia development

PMID:14551910[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00025510

P

complete

GO:0040035

hermaphrodite genitalia development

PMID:14551910[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00027342

P

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Waning, DL et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112 320-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Simmer, F et al. (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol. 1 E12 PubMed GONUTS page
  3. Kim, SH & Michael, WM (2008) Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans. Mol. Cell 32 757-66 PubMed GONUTS page
  4. Ghazi, A et al. (2007) Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc. Natl. Acad. Sci. U.S.A. 104 5947-52 PubMed GONUTS page