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CAEEL:CUL4
Contents
| Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
| Gene Name(s) | cul-4 | |
| Protein Name(s) | Cullin-4
CUL-4 | |
| External Links | ||
| UniProt | Q17392 | |
| EMBL | FO080734 U58086 | |
| PIR | T16367 | |
| RefSeq | NP_495525.2 | |
| UniGene | Cel.15594 | |
| ProteinModelPortal | Q17392 | |
| SMR | Q17392 | |
| IntAct | Q17392 | |
| STRING | 6239.F45E12.3 | |
| PaxDb | Q17392 | |
| PRIDE | Q17392 | |
| EnsemblMetazoa | F45E12.3 | |
| GeneID | 174198 | |
| KEGG | cel:CELE_F45E12.3 | |
| UCSC | F45E12.3 | |
| CTD | 174198 | |
| WormBase | F45E12.3 | |
| eggNOG | COG5647 | |
| GeneTree | ENSGT00760000119212 | |
| InParanoid | Q17392 | |
| KO | K10609 | |
| OMA | ERIFCSS | |
| OrthoDB | EOG7F24SC | |
| PhylomeDB | Q17392 | |
| UniPathway | UPA00143 | |
| NextBio | 882965 | |
| PRO | PR:Q17392 | |
| Proteomes | UP000001940 | |
| GO | GO:0031461 GO:0016567 GO:0006511 | |
| Gene3D | 1.10.10.10 | |
| InterPro | IPR016157 IPR016158 IPR001373 IPR019559 IPR016159 IPR011991 | |
| Pfam | PF00888 PF10557 | |
| SMART | SM00182 SM00884 | |
| SUPFAM | SSF74788 SSF75632 | |
| PROSITE | PS01256 PS50069 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
incorrect (CACAO) |
GO:0006275 |
regulation of DNA replication |
ECO:0000304 |
P |
intro “Cul4 is important for regulating DNA replication” Discussion (pg:326) without the CUL-4 cullin… multiple rounds of DNA replication were initiated in a single cell cycle, |
complete | ||||
|
incorrect (CACAO) |
GO:0048589 |
developmental growth |
ECO:0000304 |
P |
Discussion (pg:326) without the CUL-4 cullin...development arrested at the L2 larval stage.. |
complete | ||||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00001574 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0080008 |
Cul4-RING E3 ubiquitin ligase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033260 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000231993 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261268 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015509 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031461 |
cullin-RING ubiquitin ligase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000231993 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031146 |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1349658 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019005 |
SCF ubiquitin ligase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015509 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000232236 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914487 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031461 |
cullin-RING ubiquitin ligase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Waning, DL et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112 320-9 PubMed GONUTS page
- ↑ Kim, SH & Michael, WM (2008) Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans. Mol. Cell 32 757-66 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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