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MOUSE:TRAIP
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Traip (synonyms: Trip) | |
| Protein Name(s) | E3 ubiquitin-protein ligase TRAIP
TRAF-interacting protein | |
| External Links | ||
| UniProt | Q8VIG6 | |
| EMBL | U77844 AK012786 AK012948 BC006929 BC017374 | |
| CCDS | CCDS23511.1 | |
| RefSeq | NP_035764.2 | |
| UniGene | Mm.297870 | |
| ProteinModelPortal | Q8VIG6 | |
| SMR | Q8VIG6 | |
| BioGrid | 204309 | |
| PhosphoSite | Q8VIG6 | |
| PRIDE | Q8VIG6 | |
| Ensembl | ENSMUST00000049348 | |
| GeneID | 22036 | |
| KEGG | mmu:22036 | |
| UCSC | uc009rnn.1 | |
| CTD | 10293 | |
| MGI | MGI:1096377 | |
| eggNOG | NOG86944 | |
| GeneTree | ENSGT00390000007696 | |
| HOGENOM | HOG000054214 | |
| HOVERGEN | HBG059760 | |
| InParanoid | Q8VIG6 | |
| KO | K11985 | |
| OMA | KTMEQIE | |
| OrthoDB | EOG7HXCQV | |
| PhylomeDB | Q8VIG6 | |
| TreeFam | TF317309 | |
| UniPathway | UPA00143 | |
| ChiTaRS | Traip | |
| NextBio | 301806 | |
| PRO | PR:Q8VIG6 | |
| Proteomes | UP000000589 | |
| Bgee | Q8VIG6 | |
| CleanEx | MM_TRAIP | |
| Genevestigator | Q8VIG6 | |
| GO | GO:0005730 GO:0048471 GO:0016874 GO:0005057 GO:0061630 GO:0004842 GO:0008270 GO:0035556 GO:0016567 GO:0007165 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR009053 IPR001841 IPR013083 | |
| Pfam | PF13639 | |
| SMART | SM00184 | |
| SUPFAM | SSF46579 | |
| PROSITE | PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000314 |
P |
Figure 1.E TRIP expression decreased overall amount of interferon being made when compared to control thus indicating that TRAF interacting protein negatively regulates interferon-beta production. |
complete | |||||
|
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061630 |
ubiquitin protein ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000353 |
physical interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BWF2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhang, M et al. (2012) TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J. Exp. Med. 209 1703-11 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Besse, A et al. (2007) TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. Biochem. Biophys. Res. Commun. 359 660-4 PubMed GONUTS page
- ↑ Logue, SF et al. (1997) Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Behav. Neurosci. 111 104-13 PubMed GONUTS page
- ↑ 4.0 4.1 Lee, SY et al. (1997) TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. J. Exp. Med. 185 1275-85 PubMed GONUTS page
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