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MOUSE:CUL1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cul1
Protein Name(s) Cullin-1

CUL-1

External Links
UniProt Q9WTX6
EMBL AF083216
AF176910
AF136441
BC029260
CCDS CCDS20095.1
RefSeq NP_036172.1
XP_006506251.1
XP_006506252.1
XP_006506253.1
UniGene Mm.87611
ProteinModelPortal Q9WTX6
SMR Q9WTX6
BioGrid 205088
DIP DIP-39799N
IntAct Q9WTX6
MINT MINT-4092624
PhosphoSite Q9WTX6
MaxQB Q9WTX6
PaxDb Q9WTX6
PRIDE Q9WTX6
Ensembl ENSMUST00000031697
GeneID 26965
KEGG mmu:26965
UCSC uc009bsz.1
CTD 8454
MGI MGI:1349658
eggNOG COG5647
GeneTree ENSGT00760000119212
HOGENOM HOG000176713
HOVERGEN HBG106177
InParanoid Q9WTX6
KO K03347
OMA RMYNLLS
PhylomeDB Q9WTX6
TreeFam TF101151
Reactome REACT_196464
REACT_196589
REACT_196591
REACT_196604
REACT_196635
REACT_198561
REACT_199115
REACT_199121
REACT_203336
REACT_203517
REACT_220647
REACT_224208
REACT_258573
REACT_268522
REACT_268705
REACT_270923
UniPathway UPA00143
ChiTaRS Cul1
NextBio 304903
PRO PR:Q9WTX6
Proteomes UP000000589
Bgee Q9WTX6
CleanEx MM_CUL1
ExpressionAtlas Q9WTX6
Genevestigator Q9WTX6
GO GO:0019005
GO:0006915
GO:0008283
GO:0009887
GO:0006513
GO:0031146
GO:0006511
GO:0016032
Gene3D 1.10.10.10
InterPro IPR016157
IPR016158
IPR001373
IPR019559
IPR016159
IPR011991
Pfam PF00888
PF10557
SMART SM00182
SM00884
SUPFAM SSF74788
SSF75632
PROSITE PS01256
PS50069

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016567

protein ubiquitination

PMID:24819753[1]

ECO:0000314

P

This paper constructs an experiment to test the effect of Cullin-1 on tumors and its process in protein ubiquitination which provides necessary information for this annotation.

complete
CACAO 10687

involved_in

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

PMID:12140560[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:23452856[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:12140560[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q13616

C

Seeded From UniProt

complete

contributes_to

GO:0061630

ubiquitin protein ligase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000231993
SGD:S000002290

F

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261268
MGI:MGI:1347360
MGI:MGI:1349658
MGI:MGI:1914487
PANTHER:PTN000231993
PomBase:SPAC17G6.12
SGD:S000002290
UniProtKB:Q13616
UniProtKB:Q13618
UniProtKB:Q13619
UniProtKB:Q5AJB7
WB:WBGene00000837
WB:WBGene00000839

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015509
FB:FBgn0032956
FB:FBgn0033260
FB:FBgn0039632
FB:FBgn0261268
PANTHER:PTN000231993
UniProtKB:Q13617
UniProtKB:Q93034

F

Seeded From UniProt

complete

part_of

GO:0031461

cullin-RING ubiquitin ligase complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000231993
UniProtKB:Q13616
UniProtKB:Q57UJ3

C

Seeded From UniProt

complete

involved_in

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1349658
PANTHER:PTN000231993
PomBase:SPAC17G6.12
SGD:S000002290
UniProtKB:Q13616
UniProtKB:Q5AJB7

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015509
MGI:MGI:1349658
PANTHER:PTN000231993
PomBase:SPAC17G6.12
SGD:S000002290
UniProtKB:Q13616
dictyBase:DDB_G0291972

C

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914487
PANTHER:PTN000231993
SGD:S000002290
SGD:S000003235
UniProtKB:Q13618
UniProtKB:Q57UJ3

P

Seeded From UniProt

complete

part_of

GO:1990452

Parkin-FBXW7-Cul1 ubiquitin ligase complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13616

C

Seeded From UniProt

complete

contributes_to

GO:0061630

ubiquitin protein ligase activity

PMID:12665572[5]

ECO:0000305

curator inference used in manual assertion

GO:0019005

F

Seeded From UniProt

complete

part_of

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13616

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13616

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

PMID:12665572[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13616

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016567

protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009887

animal organ morphogenesis

PMID:10508527[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152042

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:10508527[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152042

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:10508527[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152042

P

occurs_in:(CL:0000221)|occurs_in:(CL:0000221)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006513

protein monoubiquitination

PMID:21343341[7]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P62878
UniProtKB:Q8BH16
UniProtKB:Q9WTX5

P

has_participant:(MGI:MGI:88557)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:12665572[5]

ECO:0000305

curator inference used in manual assertion

GO:0019005

P

Seeded From UniProt

complete

part_of

GO:1990452

Parkin-FBXW7-Cul1 ubiquitin ligase complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q13616
ensembl:ENSP00000326804

C

Seeded From UniProt

complete

part_of

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q13616
ensembl:ENSP00000326804

C

Seeded From UniProt

complete

involved_in

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q13616
ensembl:ENSP00000326804

P

Seeded From UniProt

complete

part_of

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q13616
ensembl:ENSP00000326804

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q13616
ensembl:ENSP00000326804

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001373
InterPro:IPR016157

P

Seeded From UniProt

complete

part_of

GO:0031461

cullin-RING ubiquitin ligase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016157

C

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001373
InterPro:IPR016157

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-9008717
Reactome:R-MMU-9008715
Reactome:R-MMU-9008677

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Do, SI et al. (2014) Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression. Endocr. Pathol. 25 282-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 Yoshida, Y et al. (2002) E3 ubiquitin ligase that recognizes sugar chains. Nature 418 438-42 PubMed GONUTS page
  3. ↑ Hirano, A et al. (2013) FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell 152 1106-18 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Tokuzawa, Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23 2699-708 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Dealy, MJ et al. (1999) Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat. Genet. 23 245-8 PubMed GONUTS page
  7. ↑ Chen, BB et al. (2011) Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis. Mol. Cell. Biol. 31 1905-20 PubMed GONUTS page
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