MOUSE:UBE3A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ube3a
Protein Name(s)	Ubiquitin-protein ligase E3A Oncogenic protein-associated protein E6-AP
External Links
UniProt	O08759
EMBL	U96636 U82122 AK029133 AC167971 BC131658 BC131659
CCDS	CCDS39973.1 CCDS80733.1 CCDS80734.1
RefSeq	NP_035798.2 NP_766598.1 XP_006540862.1 XP_011249149.1
UniGene	Mm.9002
ProteinModelPortal	O08759
SMR	O08759
IntAct	O08759
MINT	MINT-4139156
STRING	10090.ENSMUSP00000103161
iPTMnet	O08759
PhosphoSite	O08759
SwissPalm	O08759
EPD	O08759
MaxQB	O08759
PaxDb	O08759
PRIDE	O08759
Ensembl	ENSMUST00000107537 ENSMUST00000200758 ENSMUST00000202945
GeneID	22215
KEGG	mmu:22215
UCSC	uc009heg.1
CTD	7337
MGI	MGI:105098
eggNOG	KOG0941 COG5021
GeneTree	ENSGT00830000128260
HOGENOM	HOG000261634
HOVERGEN	HBG059326
InParanoid	O08759
KO	K10587
OMA	VEEDMMI
TreeFam	TF315189
BRENDA	6.3.2.19
UniPathway	UPA00143
ChiTaRS	Ube3a
PRO	PR:O08759
Proteomes	UP000000589
Bgee	E9QKT1
CleanEx	MM_UBE3A
ExpressionAtlas	O08759
Genevisible	O08759
GO	GO:0005829 GO:0005634 GO:0000502 GO:0016874 GO:0046872 GO:0003713 GO:0061630 GO:0004842 GO:0030521 GO:0001541 GO:0014068 GO:0031398 GO:0045944 GO:0060736 GO:0051865 GO:0070936 GO:0016567 GO:0042752 GO:2000058 GO:0035037 GO:0006511
InterPro	IPR032353 IPR000569 IPR017134
Pfam	PF16558 PF00632
PIRSF	PIRSF037201
SMART	SM00119
SUPFAM	SSF56204
PROSITE	PS50237

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1905528	positive regulation of Golgi lumen acidification	PMID:23447592^[1]	ECO:0000315			P		A fluorometric assay was used to determine Golgi lumen pH in Ube3a-deficient mouse neurons as compared to the wild type. Figure 5B shows the calibration curve used to convert YFP:CFP intensity ratio to pH; Figure 5G shows the fluorescence intensity and figure 5H shows the pH as calculated using the calibration curve.	complete CACAO 12116
involved_in	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
involved_in	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:24728990^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05086	F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0061469 PANTHER:PTN002258255	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0061469 MGI:MGI:105098 PANTHER:PTN002258255	P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0061469 PANTHER:PTN002258255	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	PMID:9182527^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306361	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060736	prostate gland growth	PMID:16254014^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181811	P	occurs_in:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060736	prostate gland growth	PMID:11756548^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181811	P	occurs_in:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051865	protein autoubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16254014^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88064	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042752	regulation of circadian rhythm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035037	sperm entry	PMID:11756548^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032570	response to progesterone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	PMID:16254014^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19091	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	PMID:9182527^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:16254014^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:16254014^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:9182527^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9182527^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05086	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:16254014^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	PMID:11756548^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181811	P	results_in_development_of:(EMAPA:35627)	Seeded From UniProt	complete
involved_in	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7B8 ensembl:ENSRNOP00000021366	P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7B8 ensembl:ENSRNOP00000021366	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7B8 ensembl:ENSRNOP00000021366	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7B8 ensembl:ENSRNOP00000021366	P		Seeded From UniProt	complete
involved_in	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	F		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	P		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	P		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	P		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05086 ensembl:ENSP00000497594	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000569 InterPro:IPR035983	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017134	P		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017134	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0000502	proteasome complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0647	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Condon, KH et al. (2013) The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. J. Neurosci. 33 3799-814 PubMed GONUTS page
↑ Gossan, NC et al. (2014) The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor. Nucleic Acids Res. 42 5765-75 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Hatakeyama, S et al. (1997) Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J. Biol. Chem. 272 15085-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Khan, OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol. Endocrinol. 20 544-59 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Smith, CL et al. (2002) Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. Mol. Cell. Biol. 22 525-35 PubMed GONUTS page

[PMID:23447592-1] Condon, KH et al. (2013) The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. J. Neurosci. 33 3799-814 PubMed GONUTS page

[PMID:24728990-2] Gossan, NC et al. (2014) The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor. Nucleic Acids Res. 42 5765-75 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9182527-4] 4.0 ^4.1 ^4.2 ^4.3 Hatakeyama, S et al. (1997) Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J. Biol. Chem. 272 15085-92 PubMed GONUTS page

[PMID:16254014-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Khan, OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol. Endocrinol. 20 544-59 PubMed GONUTS page

[PMID:11756548-6] 6.0 ^6.1 ^6.2 Smith, CL et al. (2002) Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. Mol. Cell. Biol. 22 525-35 PubMed GONUTS page

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MOUSE:UBE3A

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