MOUSE:PTEN

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pten (synonyms: Mmac1)
Protein Name(s)	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Mutated in multiple advanced cancers 1 Phosphatase and tensin homolog
External Links
UniProt	O08586
EMBL	U92437 AK076980 AK088717 AK148736 BC021445
CCDS	CCDS29753.1
RefSeq	NP_032986.1
UniGene	Mm.245395
ProteinModelPortal	O08586
SMR	O08586
BioGrid	202449
DIP	DIP-38740N
IntAct	O08586
MINT	MINT-128418
PhosphoSite	O08586
MaxQB	O08586
PaxDb	O08586
PRIDE	O08586
Ensembl	ENSMUST00000013807
GeneID	19211
KEGG	mmu:19211
UCSC	uc008hfr.1
CTD	5728
MGI	MGI:109583
eggNOG	COG2453
GeneTree	ENSGT00760000119113
HOGENOM	HOG000008008
HOVERGEN	HBG000239
InParanoid	O08586
KO	K01110
OMA	RSINENK
OrthoDB	EOG7R2BJ5
PhylomeDB	O08586
TreeFam	TF324513
Reactome	REACT_196473 REACT_196588 REACT_198973 REACT_214733 REACT_225145
ChiTaRS	Pten
NextBio	295956
PRO	PR:O08586
Proteomes	UP000000589
Bgee	O08586
CleanEx	MM_PTEN
ExpressionAtlas	O08586
Genevestigator	O08586
GO	GO:0005737 GO:0009898 GO:0043197 GO:0005739 GO:0035749 GO:0043005 GO:0005634 GO:0016605 GO:0045211 GO:0043220 GO:0051717 GO:0000287 GO:0030165 GO:0016314 GO:0051800 GO:0004438 GO:0019901 GO:0004722 GO:0004725 GO:0008138 GO:0007092 GO:0007568 GO:0001525 GO:0006915 GO:0048854 GO:0060070 GO:0048738 GO:0016477 GO:0007417 GO:0032286 GO:0021955 GO:0060997 GO:0021542 GO:0043542 GO:0048853 GO:0007507 GO:0046855 GO:0007611 GO:0045475 GO:0007626 GO:0060292 GO:0060291 GO:0060179 GO:0042711 GO:0007613 GO:0033555 GO:0043066 GO:0050771 GO:0090344 GO:0030336 GO:0008285 GO:0045792 GO:0031658 GO:0061002 GO:0050680 GO:0090394 GO:0051895 GO:2000134 GO:0031642 GO:0046621 GO:0050765 GO:0051898 GO:0090071 GO:2000808 GO:0007270 GO:0035335 GO:0046856 GO:0048008 GO:2001235 GO:0008284 GO:2000463 GO:2000060 GO:0051091 GO:0097107 GO:0060134 GO:0097105 GO:0060736 GO:0006470 GO:0043491 GO:0050821 GO:0002902 GO:0051726 GO:0032535 GO:0033032 GO:0010975 GO:0031647 GO:0046685 GO:0033198 GO:0042493 GO:0032355 GO:0045471 GO:0009749 GO:0007584 GO:0010043 GO:0060024 GO:0035176 GO:0007416 GO:0060074
Gene3D	3.90.190.10
InterPro	IPR017361 IPR000008 IPR000340 IPR029021 IPR014020 IPR029023 IPR016130
Pfam	PF00782 PF10409
PIRSF	PIRSF038025
SUPFAM	SSF49562 SSF52799
PROSITE	PS51182 PS51181

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043005	neuron projection	PMID:21664258	ECO:0000315			C		Synaptosomal fraction from brain of wild type mice, figure 5A	complete CACAO 2353
	GO:0051898	negative regulation of protein kinase B signaling	PMID:16675393	ECO:0000315			P		Pten mutant mice showed increase phosphor-Ser473-Akt (P-Akt) which is a marker for Akt activation in the dentate gyrus. Therefore Pten has a negative regulation role in the PIK3/Akt signalling pathway compared to wild type. Figure 1C.	complete CACAO 2637
	GO:0035176	social behavior	PMID:16675393	ECO:0000315			P		Control mice exposed to novel mice exhibited typical behaviour of approaching and sniffing (typical social behaviour for mice) but this initial social interaction was decreased in mutant Pten mice, figure 2A. When control mice re-exposed to same mouse, social interaction decreased from initial interaction indicating recognition of familiar mouse showing normal social learning. However this decrease was not seen in mutant mice showing impaired social initial interaction. Similar result seen in figure 2E. In the test there are two cages one with a adult mouse and another cage with a inanimate object. Control mice spent more time interacting with social target than inanimate target. However Pten mutant mice showed decreased interaction with social target compared to control. Pten mutant mice spent equal amount of time with social target and inanimate target. Figure 2F, Same result results were in a three roomed chamber. When mice were exposed to novel mouse and familiar mouse, control mouse spend more time with novel mouse than familiar mouse but the Pten mutant mice showed no preference of either novel or familiar mouse figure 2G.	complete CACAO 2639
	GO:0030534	adult behavior	PMID:16675393	ECO:0000315			P		Figure 2B, control mice showed immediate activity of nest formation but mutant mice showed later nest forming activity.	complete CACAO 2640
	GO:0060179	male mating behavior	PMID:16675393	ECO:0000315			P		Control male mouse made females pregnant but mutant Pten males did not make female mice pregnant. Figure 2H.	complete CACAO 2641
	GO:0042711	maternal behavior	PMID:16675393	ECO:0000315			P		When Pten mutant female mice were pregnant and delivered normal size pups, after 5 days the survival rate of pups were decreased in Pten females pups compared to wild type, figure 2H.	complete CACAO 2642
	GO:0007626	locomotory behavior	PMID:16675393	ECO:0000315			P		Mutant mice showed hyperactivity in more stressful conditions such as being in a bright environment of open field, therefore traveling further and at a increased average speed, figure 3A. But locomotor activity was normal in dark enclosed environment Figure supplementary data 1A and 1B.	complete CACAO 2643
	GO:0060134	prepulse inhibition	PMID:16675393	ECO:0000315			P		Figure 3B: Pten mutant mice increased initial startle response compared to control. Sensorimotor gating was measured by prepulse inhibition (PPI) paradigm which was impaired in mutant Pten mice compared to control figure 3C	complete CACAO 2644
	GO:0007611	learning or memory	PMID:16675393	ECO:0000315			P		In Morris water maze, when the platform was submerged, Pten mutant mice did not learn as quickly in terms of time and distance compared to control, figure 3G. In figure 3H, control mice spent more time in target quadrant compared to mutant Pten mice where no preference was shown.	complete CACAO 2645
	GO:0001966	thigmotaxis	PMID:16675393	ECO:0000315			P		In the Morris water maze, mutant Pten mice showed to swim more long the edge of the maze which was also seen in the open field test compared to control, figure 3I.	complete CACAO 2646
	GO:0048853	forebrain morphogenesis	PMID:16675393	ECO:0000315			P		Mutant Pten mice showed progressive macrocephaly (abnormal large head) compared to control (figure 4A). Progressive macrocephaly was seen in the forebrain area (cortex and hippocampus figure 4b and C)	complete CACAO 2647
	GO:0045792	negative regulation of cell size	PMID:16675393	ECO:0000315			P		Supplementary figure S2A-C shows that aging mice as increase in soma hypertrophy of Pten mutant mice compared to control.	complete CACAO 2648
	GO:0021955	central nervous system neuron axonogenesis	PMID:16675393	ECO:0000315			P		Figure 5A showed abnormal axonal processes in mutant Pten mice compared to control. Also figure 5B shows abnormal axonal projection in dentate gyrus mossy fiber tracts. Adult mutant Pten mice showed enlargement of mossy fiber tract (supplementary figure 3A and B)	complete CACAO 2649
	GO:2000808	negative regulation of synaptic vesicle clustering	PMID:16675393	ECO:0000315			P		Figure 5C shows Pten mutant mice had increase presynaptic vesicles compared to control.	complete CACAO 2650
	GO:0061002	negative regulation of dendritic spine morphogenesis	PMID:16675393	ECO:0000315			P		Figure 6A, showed 3 month old mutant Pten mice had thickened elongated processes. Also dendritic hypertrophy seen in adult mutant Pten mice in the dentate gyrus, figure 6B. Also figure 6C shows increase of 24.9% in dendritic spine density in mutant Pten mice compared to control mice.	complete CACAO 2651
	GO:0060024	rhythmic synaptic transmission	PMID:17706614	ECO:0000315			P		Figure 1C: seizure activity increased with age in mutant Pten mice compared to control resulting in abnormal rhythmic synaptic transmission	complete CACAO 2652
	GO:0021542	dentate gyrus development	PMID:17706614	ECO:0000315			P		Pten mutant mice showed dispersion of dentate granule neurons in mutant Pten mice compared to control, figure3.	complete CACAO 2653
	GO:0045475	locomotor rhythm	PMID:17706614	ECO:0000315			P		Figure 4A, Pten mutant mice showed increase locomotor activity compared to control in the dark but no difference in the light. Similar results seen in wheel running task, figure 5. Figure 6A and B, difference in locomotor activity, Pten mutant mice showed more breaks in the dark compared wild type where wild type mice showed constant rate of locomotor activity.	complete CACAO 2654
	GO:0032535	regulation of cellular component size	PMID:18082964	ECO:0000315			P		GFAP-crecombinase was used to knockout Pten in mice hippocampus neurons. Used electron microscopy, found changes in knockout PTEN pyramidal neurons in cerebral cortex compared to control. There was increase in nuclei and somata of neurons in knockout Pten mice compared to control, figure 1A and B. In addition, mitochondria of knockout Pten mice were enlarged. Similar result were seen in Pten knockout mice in cerebellar granule neurons, where there was enlargement in nuclear size (figure 4A and B)	complete CACAO 2658
	GO:0090071	negative regulation of ribosome biogenesis	PMID:18082964	ECO:0000315			P		Figure 1C and D shows increase of ribosome density into dendritic and axonal projections proximal to the somata of Pten knockout mice compared to control. This was not due to increase in number of nucleoli, figure 1F.	complete CACAO 2659
	GO:0060997	dendritic spine morphogenesis	PMID:18082964	ECO:0000315			P		Figure 2C and 2D, Pten knockout mice showed enlarge dendritic projections and increase in density of dendritic spines compared to control. In addition the morphology was abnormal and lacked distinct mushroom shaped termini.	complete CACAO 2660
	GO:0097105	presynaptic membrane assembly	PMID:18082964	ECO:0000315			P		Figure 3 A-D, Pten knockout mice had presynaptic terminal present but enlarged and densely packed with increase number of synaptic vesicles compared to control. Similar result were seen in Pten knockout mice in cerebellar granule neurons, figure 4C and E.	complete CACAO 2661
	GO:2000808	negative regulation of synaptic vesicle clustering	PMID:18082964	ECO:0000315			P		Figure 3 A-D, Pten knockout mice had presynaptic terminal present but enlarged and densely packed with increase number of synaptic vesicles compared to control. Figure 3E and F show Pten knockout mice enlarged presynaptic terminals with increase synaptic vesicles seen by increase immunofluorescent staining synaptic vesicles marker (synaptophysin) in cerebral cortex compared to control. Similar results were seen in Pten knockout mice in cerebellar granule neurons, figure 4C and E.	complete CACAO 2662
	GO:0097107	postsynaptic density assembly	PMID:18082964	ECO:0000315			P		Figure 3B, Pten knockout showed that in greater than 60% enlarge presynaptic terminals, there was no postsynaptic density. Similar result were seen in Pten knockout mice in cerebellar granule neurons, figure 4D and F	complete CACAO 2663
	GO:0060074	synapse maturation	PMID:18082964	ECO:0000315			P		Figure 3D, mutant Pten mice showed abnormal synaptic connections when postsynaptic density was present with abnormal structure with increase in size compared to control. Similar results were seen in Pten knockout mice in cerebellar granule neurons, figure 4F.	complete CACAO 2664
	GO:0007270	neuron-neuron synaptic transmission	PMID:18082964	ECO:0000315			P		Synaptic transmission measured at excitatory synapses between CA3 and CA1 neurons of the hippocampus. Figure 5A showed decrease in synaptic transmission.	complete CACAO 2665
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:18082964	ECO:0000315			P		Figure 5 A-C, fEPSP were significantly impaired in Pten knockout mice compared to wild type.	complete CACAO 2666
	GO:0060291	long-term synaptic potentiation	PMID:18082964	ECO:0000315			P		To investigate if synaptic transmission is impaired due to presynaptic function, pair-pulse ratio was used. No difference was seen between wild type and Pten knockout mice. There was no impairment in neurotransmitter release from presynaptic terminal, figure 5B. Therefore synaptic plasticity was investigated by measuring long-term potentiation (LTP) at CA3-CA1 synapse. Figure 5C shows decrease in LTP in Pten knockout mice compared to wild type, reduced by more than 70%	complete CACAO 2667
	GO:0032286	central nervous system myelin maintenance	PMID:18082964	ECO:0000315			P		Figure 6B and D shows thickening of myelin sheath and regions of unravelling myelin compared to wild type where myelin was tightly wrapped in the corpus callosum figure 6A and C. Figure 7J shows that Pten mice show enlarged oligodendrocytes compared to wild type. Therefore loss of functional oligodendrocytes leads to myelination defects.	complete CACAO 2668
	GO:0048854	brain morphogenesis	PMID:19208814	ECO:0000315			P		Heterozygous Pten mice resulted in macrocephaly in males and females, figure 1A-C. There was increase in brain size; therefore Pten has a negative regulation on brain growth.	complete CACAO 2673
	GO:0046621	negative regulation of organ growth	PMID:19208814	ECO:0000315			P		Heterozygous Pten mice resulted in macrocephaly in males and females, figure 1A-C. There was increase in brain size; therefore Pten has a negative regulation on brain growth.	complete CACAO 2674
	GO:0035176	social behavior	PMID:19208814	ECO:0000315			P		To measure social behaviour an apparatus that contained two chambers, one with a mouse and the other chamber with inanimate object (figure 2A). Wild type Pten mice spend more time with novel mouse instead of inanimate object whereas mutant Pten female mice did not show preference over the social and non-social chamber, figure 2B.	complete CACAO 2675
	GO:0060134	prepulse inhibition	PMID:19208814	ECO:0000315			P		Figure 2D shows Pten mutant mice was impaired in prepluse inhibition of acoustic startle response compared to control.	complete CACAO 2676
	GO:0045792	negative regulation of cell size	PMID:21411674	ECO:0000315			P		Figure 2A, Pten knockdown granule cells showed increase in cross-sectional area compared to control.	complete CACAO 2682
	GO:0060997	dendritic spine morphogenesis	PMID:21411674	ECO:0000315			P		Figure 2B, Pten knockdown neurons were thicker dendrites with more filopodial-like protrusion and aberrant protrusion extruding from existing spines Pten knockdown granule cells. Figure 2B also shows increase in spine density in Pten knockdown compared to control.	complete CACAO 2683
	GO:0090394	negative regulation of excitatory postsynaptic membrane potential	PMID:21411674	ECO:0000315			P		Examine synaptic activity. Pten knockdown mice showed increase mEPSC frequency, compared to control, figure 6B, C, figure 7A.	complete CACAO 2684
	GO:0060341	regulation of cellular localization	PMID:21266327	ECO:0000315			P		Fig 4C shows a shift in FoxO1 localization from the nucleus to the cytoplasm in Pten knockout mutants.	complete CACAO 5937
	GO:0051898		3712499:3712499	ECO:0000314					Figure 8	complete CACAO 10940
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation		ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000013D17D_10090	P		Seeded From UniProt	complete
involved_in	GO:0048681	negative regulation of axon regeneration		ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21664258	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation		ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000006FDD4_10090	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation		ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling		ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0090394	negative regulation of excitatory postsynaptic potential	PMID:21411674	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21411674	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	PMID:21411674	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032286	central nervous system myelin maintenance	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007270	neuron-neuron synaptic transmission	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060341	regulation of cellular localization	PMID:21266327	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000808	negative regulation of synaptic vesicle clustering	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090071	negative regulation of ribosome biogenesis	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032535	regulation of cellular component size	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:17706614	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	PMID:17706614	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060024	rhythmic synaptic transmission	PMID:17706614	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000808	negative regulation of synaptic vesicle clustering	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021955	central nervous system neuron axonogenesis	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060179	male mating behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000808	negative regulation of synaptic vesicle clustering	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000808	negative regulation of synaptic vesicle clustering	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090394	negative regulation of excitatory postsynaptic potential	PMID:21411674	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090344	negative regulation of cell aging	PMID:21241890	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090071	negative regulation of ribosome biogenesis	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21411674	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060179	male mating behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060024	rhythmic synaptic transmission	PMID:17706614	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050771	negative regulation of axonogenesis	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	PMID:21411674	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:17706614	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	PMID:20237282	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21664258	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035749	myelin sheath adaxonal region	PMID:20237282	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:19208814	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033555	multicellular organismal response to stress	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032535	regulation of cellular component size	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032286	central nervous system myelin maintenance	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021955	central nervous system neuron axonogenesis	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021542	dentate gyrus development	PMID:17706614	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21241890	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:16675393	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007270	neuron-neuron synaptic transmission	PMID:18082964	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904668	positive regulation of ubiquitin protein ligase activity	PMID:21241890	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:10339565	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
involved_in	GO:0046855	inositol phosphate dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:20940307	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10339565	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20940307	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60806	F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	PMID:19778506	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0004438	phosphatidylinositol-3-phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:9778245	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	F		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	PMID:26280536	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904668	positive regulation of ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903690	negative regulation of wound healing, spreading of epidermal cells	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071361	cellular response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071257	cellular response to electrical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:25512490	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060736	prostate gland growth	PMID:15994948	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183284	P	occurs_in:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060292	long-term synaptic depression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	PMID:25512490	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156086,MGI:MGI:5051834	P	regulates_o_occurs_in:(EMAPA:30445) occurs_in:(EMAPA:30445)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	PMID:20448149	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:18577) regulates_o_occurs_in:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	PMID:26280536	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	PMID:18332125	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98834	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051548	negative regulation of keratinocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050765	negative regulation of phagocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:15994948	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183284	P	occurs_in:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048738	cardiac muscle tissue development	PMID:16107612	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136412,MGI:MGI:2182005	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048679	regulation of axon regeneration		ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046855	inositol phosphate dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044320	cellular response to leptin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043542	endothelial cell migration	PMID:16107612	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136412,MGI:MGI:2182005	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036294	cellular response to decreased oxygen levels		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033032	regulation of myeloid cell apoptotic process	PMID:9990064	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857466	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032228	regulation of synaptic transmission, GABAergic		ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156086	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031642	negative regulation of myelination	PMID:20448149	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:18577) regulates_o_has_participant:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:12091320	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183285	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PMID:9778245	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	F		Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010719	negative regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16027168	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102548	P	regulates_o_occurs_in:(EMAPA:35523)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16027169	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857936	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15755804	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3578141	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:12091320	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006470	protein dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18562292	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14522255	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35714)|part_of:(EMAPA:32290)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18562292	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18332125	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14522255	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35714)|part_of:(EMAPA:32290)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61995	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
enables	GO:0004438	phosphatidylinositol-3-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002902	regulation of B cell apoptotic process	PMID:9990064	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857466	P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:16107612	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136412,MGI:MGI:2182005	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F6KD01 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F6KD01 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0060292	long-term synaptic depression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0050765	negative regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0046685	response to arsenic-containing substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
involved_in	GO:0033198	response to ATP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54857 ensembl:ENSRNOP00000028143	F		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:1904668	positive regulation of ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:1903690	negative regulation of wound healing, spreading of epidermal cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0071257	cellular response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
enables	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
involved_in	GO:0051548	negative regulation of keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0046855	inositol phosphate dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
enables	GO:0004438	phosphatidylinositol-3-phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	F		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60484 ensembl:ENSP00000361021	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016130	F		Seeded From UniProt	complete
enables	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	F		Seeded From UniProt	complete
involved_in	GO:0046855	inositol phosphate dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	P		Seeded From UniProt	complete
involved_in	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	P		Seeded From UniProt	complete
enables	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	F		Seeded From UniProt	complete
enables	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017361	F		Seeded From UniProt	complete
enables	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.67	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.16	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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References

See Help:References for how to manage references in GONUTS.