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PMID:21266327
| Citation |
Gu, Y, Lindner, J, Kumar, A, Yuan, W and Magnuson, MA (2011) Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes 60:827-37 |
|---|---|
| Abstract |
We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both β-cell mass and function. |
| Links |
PubMed PMC3046843 Online version:10.2337/db10-1194 |
| Keywords |
Alleles; Analysis of Variance; Animals; Apoptosis/physiology; Blotting, Western; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Proliferation; Cell Size; Fluorescent Antibody Technique; Genotype; Glucose/metabolism; Glucose Intolerance/genetics; Glucose Intolerance/metabolism; Hyperglycemia/genetics; Hyperglycemia/metabolism; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/metabolism; Mice; Mice, Knockout; PTEN Phosphohydrolase/genetics; PTEN Phosphohydrolase/metabolism; Phosphorylation/physiology; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060341: regulation of cellular localization |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0060341: regulation of cellular localization |
ECO:0000315: |
P |
Fig 4C shows a shift in FoxO1 localization from the nucleus to the cytoplasm in Pten knockout mutants. |
complete | ||||
See also
References
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