HUMAN:SFRP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SFRP2 (synonyms: FRP2, SARP1)
Protein Name(s)	Secreted frizzled-related protein 2 FRP-2 sFRP-2 Secreted apoptosis-related protein 1 SARP-1
External Links
UniProt	Q96HF1
EMBL	AF311912 AY359001 AK075372 CH471056 BC008666 AF017986
CCDS	CCDS34082.1
PIR	JE0174
RefSeq	NP_003004.1
UniGene	Hs.481022
ProteinModelPortal	Q96HF1
SMR	Q96HF1
BioGrid	112321
STRING	9606.ENSP00000274063
MEROPS	I93.001
PhosphoSite	Q96HF1
DMDM	61216828
PaxDb	Q96HF1
PRIDE	Q96HF1
Ensembl	ENST00000274063
GeneID	6423
KEGG	hsa:6423
UCSC	uc003inv.1
CTD	6423
GeneCards	GC04M154701
HGNC	HGNC:10777
HPA	HPA002652
MIM	604157
neXtProt	NX_Q96HF1
PharmGKB	PA35693
eggNOG	NOG240950
GeneTree	ENSGT00760000118864
HOGENOM	HOG000231058
HOVERGEN	HBG052928
InParanoid	Q96HF1
KO	K02176
OMA	TSLKRWQ
OrthoDB	EOG789CBZ
PhylomeDB	Q96HF1
TreeFam	TF350133
Reactome	REACT_200643
SignaLink	Q96HF1
ChiTaRS	SFRP2
GeneWiki	SFRP2
GenomeRNAi	6423
NextBio	24943
PRO	PR:Q96HF1
Proteomes	UP000005640
Bgee	Q96HF1
CleanEx	HS_SFRP2
ExpressionAtlas	Q96HF1
Genevestigator	Q96HF1
GO	GO:0005737 GO:0031012 GO:0005615 GO:0005886 GO:0061133 GO:0001968 GO:0005178 GO:0010577 GO:0030165 GO:0048018 GO:0042813 GO:0017147 GO:0060349 GO:0007420 GO:0003214 GO:0007267 GO:0031668 GO:0071481 GO:0002063 GO:0030199 GO:0060028 GO:0048546 GO:0042733 GO:0008406 GO:0071425 GO:0008584 GO:0030514 GO:0090090 GO:0010667 GO:0030308 GO:0030336 GO:0008285 GO:0043154 GO:0061185 GO:0050680 GO:0010719 GO:1902042 GO:0010629 GO:1902230 GO:0043508 GO:0042662 GO:0050732 GO:2000041 GO:0045892 GO:0030178 GO:0001843 GO:0003151 GO:0001569 GO:0090179 GO:0045766 GO:0043065 GO:0090263 GO:0035413 GO:0033630 GO:0030307 GO:0008284 GO:0045600 GO:0045669 GO:0033138 GO:0045944 GO:0036342 GO:2000035 GO:0042493 GO:0007584 GO:0061056 GO:0001944 GO:0090244
Gene3D	1.10.2000.10
InterPro	IPR015526 IPR020067 IPR001134 IPR018933 IPR026558 IPR008993
PANTHER	PTHR11309 PTHR11309:SF45
Pfam	PF01392 PF01759
SMART	SM00643 SM00063
SUPFAM	SSF50242 SSF63501
PROSITE	PS50038 PS50189

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	PMID:24431302^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:24431302^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	part_of:(GO:0030178)	Seeded From UniProt	complete
involved_in	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q863H1	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0061185	negative regulation of dermatome development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0061056	sclerotome development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17848950^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q863H1	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q863H1	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:17848950^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q863H1	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q863H1	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q863H1	F		Seeded From UniProt	complete
involved_in	GO:0003214	cardiac left ventricle morphogenesis	PMID:19593212^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:19593212^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q863H1	F		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:2000035	regulation of stem cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:17471511^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	PMID:10980594^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	PMID:19095296^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19095296^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:10980594^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:20208569^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:10980594^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	PMID:20208569^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	PMID:19095296^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:10980594^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97299	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:20208569^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10980594^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10980594^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108078 MGI:MGI:892014 PANTHER:PTN002259328 RGD:621074 RGD:735163 UniProtKB:Q5T4F7 UniProtKB:Q8N474 UniProtKB:Q96HF1	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 PANTHER:PTN000139394 RGD:61916 RGD:71012 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q8N474 UniProtKB:Q9H461 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	P		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108570 PANTHER:PTN000139394 UniProtKB:O60353 ZFIN:ZDB-GENE-990415-218	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 FB:FBgn0027342 FB:FBgn0027343 MGI:MGI:108078 MGI:MGI:108460 MGI:MGI:108474 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:892032 PANTHER:PTN000139394 RGD:621075 RGD:631406 RGD:71017 UniProtKB:O00144 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q6FHJ7 UniProtKB:Q8N474 UniProtKB:Q9NPG1 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108078 PANTHER:PTN002259328 UniProtKB:O19116 UniProtKB:Q863H1 UniProtKB:Q8N474 UniProtKB:Q96HF1	C		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	PMID:12055200^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WBV2 ensembl:ENSRNOP00000012659	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WBV2 ensembl:ENSRNOP00000012659	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WBV2 ensembl:ENSRNOP00000012659	P		Seeded From UniProt	complete
involved_in	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:2000035	regulation of stem cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:1904956	regulation of midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0090244	Wnt signaling pathway involved in somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0090179	planar cell polarity pathway involved in neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0090175	regulation of establishment of planar polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0071481	cellular response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0071425	hematopoietic stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0061185	negative regulation of dermatome development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
enables	GO:0061133	endopeptidase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	F		Seeded From UniProt	complete
involved_in	GO:0061056	sclerotome development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0060028	convergent extension involved in axis elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0048546	digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	F		Seeded From UniProt	complete
involved_in	GO:0046546	development of primary male sexual characteristics	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0042662	negative regulation of mesodermal cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0031668	cellular response to extracellular stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0030111	regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	F		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0010950	positive regulation of endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	C		Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97299 ensembl:ENSMUSP00000029625	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ ^2.0 ^2.1 Cheng, YY et al. (2007) Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br. J. Cancer 97 895-901 PubMed GONUTS page
↑ ^3.0 ^3.1 Arnett, DK et al. (2009) Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. J. Hypertens. 27 1585-93 PubMed GONUTS page
↑ Bhat, RA et al. (2007) Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function. J. Cell. Biochem. 102 1519-28 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Roth, W et al. (2000) Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene 19 4210-20 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Chung, MT et al. (2009) SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol. Oncol. 112 646-53 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Kongkham, PN et al. (2010) The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene 29 3017-24 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page

[PMID:24431302-1] 1.0 ^1.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:17848950-2] 2.0 ^2.1 Cheng, YY et al. (2007) Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br. J. Cancer 97 895-901 PubMed GONUTS page

[PMID:19593212-3] 3.0 ^3.1 Arnett, DK et al. (2009) Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. J. Hypertens. 27 1585-93 PubMed GONUTS page

[PMID:17471511-4] Bhat, RA et al. (2007) Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function. J. Cell. Biochem. 102 1519-28 PubMed GONUTS page

[PMID:10980594-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Roth, W et al. (2000) Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene 19 4210-20 PubMed GONUTS page

[PMID:19095296-6] 6.0 ^6.1 ^6.2 Chung, MT et al. (2009) SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol. Oncol. 112 646-53 PubMed GONUTS page

[PMID:20208569-7] 7.0 ^7.1 ^7.2 Kongkham, PN et al. (2010) The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene 29 3017-24 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12055200-9] Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page

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HUMAN:SFRP2

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