MOUSE:WNT3A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wnt3a (synonyms: Wnt-3a)
Protein Name(s)	Protein Wnt-3a
External Links
UniProt	P27467
EMBL	X56842
CCDS	CCDS24766.1
PIR	A39532
RefSeq	NP_033548.1
UniGene	Mm.1367
ProteinModelPortal	P27467
SMR	P27467
BioGrid	204575
DIP	DIP-55954N
IntAct	P27467
MINT	MINT-7992042
STRING	10090.ENSMUSP00000010044
BindingDB	P27467
ChEMBL	CHEMBL5617
PhosphoSite	P27467
PRIDE	P27467
DNASU	22416
Ensembl	ENSMUST00000010044
GeneID	22416
KEGG	mmu:22416
UCSC	uc007jdp.2
CTD	89780
MGI	MGI:98956
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039529
HOVERGEN	HBG001595
InParanoid	P27467
KO	K00312
OMA	CTTVNDS
OrthoDB	EOG7C8GJ8
PhylomeDB	P27467
TreeFam	TF105310
Reactome	REACT_207044 REACT_210612 REACT_213035 REACT_213918 REACT_216784 REACT_241644 REACT_250061
NextBio	302833
PRO	PR:P27467
Proteomes	UP000000589
Bgee	P27467
CleanEx	MM_WNT3A
Genevestigator	P27467
GO	GO:0009986 GO:0005788 GO:0005615 GO:0005578 GO:0005109 GO:0005110 GO:0019904 GO:0005102 GO:0003713 GO:0009952 GO:0090245 GO:0007411 GO:0007409 GO:0030509 GO:0060070 GO:0061317 GO:0060923 GO:0021846 GO:0007267 GO:0034613 GO:0010387 GO:0007368 GO:0021904 GO:0030198 GO:0001947 GO:0030097 GO:0021766 GO:0001701 GO:0042472 GO:0030879 GO:0007498 GO:0048843 GO:0045599 GO:0003136 GO:0050768 GO:0010977 GO:0009887 GO:0001649 GO:0060021 GO:0048343 GO:0030168 GO:0070527 GO:0030890 GO:0090263 GO:2000081 GO:2000727 GO:0035413 GO:0008284 GO:2000049 GO:0048697 GO:0043280 GO:0001819 GO:0061184 GO:0048337 GO:2000179 GO:0033138 GO:0032092 GO:0061098 GO:0002092 GO:0051091 GO:0045944 GO:0045893 GO:0036342 GO:0050770 GO:0045595 GO:0070507 GO:0007165 GO:0035914 GO:0048103 GO:0001756 GO:0021527 GO:0016055 GO:0021874
InterPro	IPR005817 IPR009141 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01843 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:11856745^[1]	ECO:0000315			P		Figure 1	complete CACAO 6889
part_of	GO:0005615	extracellular space	PMID:26902720^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:26902720^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:12610652^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1180	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0090676	calcium ion transmembrane transport via low voltage-gated calcium channel	PMID:20371816^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:20371816^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20371816^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000020866) occurs_in:(UBERON:0004703)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19001373^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:22899650^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q5S007)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:17244647^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q60838) part_of:(GO:0060070)\|has_regulation_target(UniProtKB:Q61062) part_of:(GO:0060070)	Seeded From UniProt	complete
involved_in	GO:1904339	negative regulation of dopaminergic neuron differentiation	PMID:14557550^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17244647^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:17244647^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9JMK2) occurs_in:(CL:0000700)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:17027228^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0060070) has_regulation_target:(UniProtKB:P51141) occurs_in:(CL:0000700)\|part_of(GO:0060070) has_regulation_target:(UniProtKB:Q60838) occurs_in:(CL:0000700)\|part_of(GO:0060070) has_regulation_target:(UniProtKB:Q61062) occurs_in:(CL:0000700)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17027228^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000700)	Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:22899650^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:10557084^[10]	ECO:0000305	curator inference used in manual assertion	GO:0048018 GO:0060070	C		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:10557084^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0016055)	Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	PMID:14557550^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	PMID:14557550^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:24080158^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033278	cell proliferation in midbrain	PMID:14557550^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0022008)	Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	PMID:22723415^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002322) occurs_at:(SO:0000167) has_regulation_target:(UniProtKB:P08775)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22723415^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000021611) occurs_in:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:11856745^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18929644^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15265686^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:12121999^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18929644^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:12843296^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18929644^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021846	cell proliferation in forebrain	PMID:12843296^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010387	COP9 signalosome assembly	PMID:17569865^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:8167409^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12897152^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000081	positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	PMID:17994217^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:10557084^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17994217^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:15454084^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01887	F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:21539518^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17994217^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17994217^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:16501258^[23]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:16501258^[23]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:16501258^[23]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:16501258^[23]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:16501258^[23]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:16501258^[23]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:16501258^[23]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:16501258^[23]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16501258^[23]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001141	regulation of RNA biosynthetic process	PMID:22665494^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000347	positive regulation of hepatocyte proliferation	PMID:23740243^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000179	positive regulation of neural precursor cell proliferation	PMID:19896444^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	PMID:10893270^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990851	Wnt-Frizzled-LRP5/6 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905606	regulation of presynapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:23740243^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:18155657^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090245	axis elongation involved in somitogenesis	PMID:11029008^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P	has_participant:(EMAPA:16183)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070527	platelet aggregation	PMID:19901330^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:18716223^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0062009	secondary palate development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061317	canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061184	positive regulation of dermatome development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:19920076^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060923	cardiac muscle cell fate commitment	PMID:21554246^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2143322	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19961844^[35]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892032	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19920076^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q08463	P	occurs_in:(EMAPA:16051)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19910923^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218 MGI:MGI:1888513	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19699733^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924828 MGI:MGI:1933114	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:16115200^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108460 MGI:MGI:108520	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15143170^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:11029008^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:10933391^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96770	P	occurs_in:(CL:0000826)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:10409711^[41]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106613 MGI:MGI:94941	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19701191^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:23677472^[43]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000451)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19961844^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19896444^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19497282^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:19075000^[45]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0007010)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18606138^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18555765^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17888405^[48]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002334)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17462603^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:16602827^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:16543246^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15796911^[52]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002334)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15579909^[53]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050807	regulation of synapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050770	regulation of axonogenesis	PMID:18716223^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048843	negative regulation of axon extension involved in axon guidance	PMID:18716223^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048697	positive regulation of collateral sprouting in absence of injury	PMID:18716223^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048343	paraxial mesodermal cell fate commitment	PMID:9126297^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048337	positive regulation of mesodermal cell fate specification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048103	somatic stem cell division	PMID:12717450^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19699733^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924828 MGI:MGI:1933114	P	regulates_o_occurs_in:(CL:0000515) has_regulation_target:(MGI:MGI:1270862)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23740243^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17360443^[56]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002322) has_regulation_target:(MGI:MGI:107543)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9356179^[57]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:17888405^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103573 MGI:MGI:88373	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:17888405^[48]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:15796911^[52]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002334)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045595	regulation of cell differentiation	PMID:12717450^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:17251350^[58]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:15961523^[59]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98953	P	has_participant:(EMAPA:16194)	Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036342	post-anal tail morphogenesis	PMID:8299937^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	has_participant:(EMAPA:16748)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035914	skeletal muscle cell differentiation	PMID:19699733^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924828 MGI:MGI:1933114	P	results_in_acquisition_of_features_of:(CL:0000515)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034613	cellular protein localization	PMID:17606995^[61]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030890	positive regulation of B cell proliferation	PMID:10933391^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:15342465^[62]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_development_of:(EMAPA:16096)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:19850029^[63]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q2LMP1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:17943183^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030168	platelet activation	PMID:19901330^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030097	hemopoiesis	PMID:12717450^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:8299937^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021874	Wnt signaling pathway involved in forebrain neuroblast division	PMID:10631167^[65]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	occurs_in:(EMAPA:16910) occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:10631167^[65]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	results_in_development_of:(EMAPA:19148)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021527	spinal cord association neuron differentiation	PMID:11877374^[66]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98953	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021527	spinal cord association neuron differentiation	PMID:11877374^[66]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:16115200^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15148409^[67]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:19690384^[68]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:8299937^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	results_in_development_of:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:18716223^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:15454084^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101766	P	occurs_in:(EMAPA:16668) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:15454084^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16668) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:16291790^[69]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	has_participant:(EMAPA:16105)\|has_participant:(EMAPA:16843)\|has_participant:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15454084^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:18606138^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61089	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:19910923^[36]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:1888513)	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003136	negative regulation of heart induction by canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002092	positive regulation of receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:16291790^[69]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P56704	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001819	positive regulation of cytokine production	PMID:23677472^[43]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000451)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:8299937^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	has_participant:(EMAPA:16184)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:16291790^[69]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857489	P	has_participant:(EMAPA:16097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:12636920^[70]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857088	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:4819561^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857088	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:16581771^[72]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88613	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
part_of	GO:1990851	Wnt-Frizzled-LRP5/6 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	C		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	C		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0061317	canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0061184	positive regulation of dermatome development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0048337	positive regulation of mesodermal cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	F		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	F		Seeded From UniProt	complete
involved_in	GO:0003136	negative regulation of heart induction by canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56704 ensembl:ENSP00000284523	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	P		Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	PMID:16243425^[73]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-MMU-3238692 Reactome:R-MMU-3238687	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-3772439 Reactome:R-MMU-3769366	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:9889131^[74]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:9889131^[74]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	PMID:9889131^[74]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9889131^[74]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Petropoulos, H & Skerjanc, IS (2002) Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells. J. Biol. Chem. 277 15393-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Mihara, E et al. (2016) Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. Elife 5 PubMed GONUTS page
↑ De Ferrari, GV et al. (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8 195-208 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Wisniewska, MB et al. (2010) LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J. Neurosci. 30 4957-69 PubMed GONUTS page
↑ Kress, E et al. (2009) The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine. J. Biol. Chem. 284 1234-41 PubMed GONUTS page
↑ ^6.0 ^6.1 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Bryja, V et al. (2007) Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell. Sci. 120 586-95 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Castelo-Branco, G et al. (2003) Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl. Acad. Sci. U.S.A. 100 12747-52 PubMed GONUTS page
↑ ^9.0 ^9.1 Bryja, V et al. (2007) Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin. Cell. Signal. 19 610-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page
↑ Xavier, CP et al. (2014) Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell. Signal. 26 94-101 PubMed GONUTS page
↑ ^12.0 ^12.1 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Verkaar, F et al. (2009) Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell. Signal. 21 22-33 PubMed GONUTS page
↑ Lyons, JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp. Cell Res. 298 369-87 PubMed GONUTS page
↑ Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page
↑ ^16.0 ^16.1 Viti, J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci. 23 5919-27 PubMed GONUTS page
↑ Bilic, J et al. (2007) Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316 1619-22 PubMed GONUTS page
↑ Smolich, BD et al. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol. Biol. Cell 4 1267-75 PubMed GONUTS page
↑ Liu, G et al. (2003) A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol. Cell. Biol. 23 5825-35 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Schinner, S et al. (2008) Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51 147-54 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page
↑ Pino, D et al. (2011) Wnt5a controls neurite development in olfactory bulb interneurons. ASN Neuro 3 e00059 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 Chen, J et al. (2006) Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation. J. Biol. Chem. 281 11910-6 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Arun, G et al. (2012) mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Mol. Cell. Biol. 32 3140-52 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page
↑ ^27.0 ^27.1 Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page
↑ Toyofuku, T et al. (2000) Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J. Cell Biol. 150 225-41 PubMed GONUTS page
↑ Ouji, Y et al. (2008) Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem. Biophys. Res. Commun. 367 299-304 PubMed GONUTS page
↑ ^30.0 ^30.1 Pinson, KI et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407 535-8 PubMed GONUTS page
↑ ^31.0 ^31.1 Steele, BM et al. (2009) Canonical Wnt signaling negatively regulates platelet function. Proc. Natl. Acad. Sci. U.S.A. 106 19836-41 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 ^32.4 Purro, SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J. Neurosci. 28 8644-54 PubMed GONUTS page
↑ ^33.0 ^33.1 Yokoyama, N & Malbon, CC (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J. Cell. Sci. 122 4439-51 PubMed GONUTS page
↑ Yasuda, S et al. (2011) AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. Biochem. J. 437 345-55 PubMed GONUTS page
↑ ^35.0 ^35.1 Alfieri, CM et al. (2010) Wnt signaling in heart valve development and osteogenic gene induction. Dev. Biol. 338 127-35 PubMed GONUTS page
↑ ^36.0 ^36.1 Sato, A et al. (2010) Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J. 29 41-54 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Brack, AS et al. (2009) BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Dev. Biol. 335 93-105 PubMed GONUTS page
↑ ^38.0 ^38.1 Takada, R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells 10 919-28 PubMed GONUTS page
↑ González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page
↑ ^40.0 ^40.1 Reya, T et al. (2000) Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13 15-24 PubMed GONUTS page
↑ Lee, JS et al. (1999) Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J. Biol. Chem. 274 21464-70 PubMed GONUTS page
↑ Suriben, R et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat. Genet. 41 977-85 PubMed GONUTS page
↑ ^43.0 ^43.1 Oderup, C et al. (2013) Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance. J. Immunol. 190 6126-34 PubMed GONUTS page
↑ Le Grand, F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4 535-47 PubMed GONUTS page
↑ Haÿ, E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 29 953-64 PubMed GONUTS page
↑ ^46.0 ^46.1 Yamamoto, S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15 23-36 PubMed GONUTS page
↑ Olkku, A & Mahonen, A (2008) Wnt and steroid pathways control glutamate signalling by regulating glutamine synthetase activity in osteoblastic cells. Bone 43 483-93 PubMed GONUTS page
↑ ^48.0 ^48.1 ^48.2 Kawai, M et al. (2007) Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem. Biophys. Res. Commun. 363 276-82 PubMed GONUTS page
↑ Wawrzak, D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun. 357 1119-23 PubMed GONUTS page
↑ Mikels, AJ & Nusse, R (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4 e115 PubMed GONUTS page
↑ Nam, JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J. Biol. Chem. 281 13247-57 PubMed GONUTS page
↑ ^52.0 ^52.1 Kanazawa, A et al. (2005) Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Biochem. Biophys. Res. Commun. 330 505-10 PubMed GONUTS page
↑ Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page
↑ Yoshikawa, Y et al. (1997) Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev. Biol. 183 234-42 PubMed GONUTS page
↑ ^55.0 ^55.1 ^55.2 Reya, T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423 409-14 PubMed GONUTS page
↑ Liu, Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 104 3859-64 PubMed GONUTS page
↑ Fan, CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev. Biol. 191 160-5 PubMed GONUTS page
↑ Mirotsou, M et al. (2007) Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc. Natl. Acad. Sci. U.S.A. 104 1643-8 PubMed GONUTS page
↑ Riccomagno, MM et al. (2005) Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev. 19 1612-23 PubMed GONUTS page
↑ ^60.0 ^60.1 ^60.2 ^60.3 Takada, S et al. (1994) Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 8 174-89 PubMed GONUTS page
↑ Schwarz-Romond, T et al. (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J. Cell. Sci. 120 2402-12 PubMed GONUTS page
↑ Chu, EY et al. (2004) Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131 4819-29 PubMed GONUTS page
↑ Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page
↑ Bayle, J et al. (2008) Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J. Invest. Dermatol. 128 871-81 PubMed GONUTS page
↑ ^65.0 ^65.1 Lee, SM et al. (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127 457-67 PubMed GONUTS page
↑ ^66.0 ^66.1 Muroyama, Y et al. (2002) Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16 548-53 PubMed GONUTS page
↑ Satoh, K et al. (2004) Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc. Natl. Acad. Sci. U.S.A. 101 8017-21 PubMed GONUTS page
↑ Cohen, ED et al. (2009) Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J. Clin. Invest. 119 2538-49 PubMed GONUTS page
↑ ^69.0 ^69.1 ^69.2 Nakaya, MA et al. (2005) Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development 132 5425-36 PubMed GONUTS page
↑ Aulehla, A et al. (2003) Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev. Cell 4 395-406 PubMed GONUTS page
↑ Grüneberg, H & Wickramaratne, GA (1974) A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J Embryol Exp Morphol 31 207-22 PubMed GONUTS page
↑ Si, W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol. Cell. Biol. 26 2955-64 PubMed GONUTS page
↑ Jankovic, J et al. () The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77 128-38 PubMed GONUTS page
↑ ^74.0 ^74.1 ^74.2 ^74.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page

[PMID:11856745-1] 1.0 ^1.1 Petropoulos, H & Skerjanc, IS (2002) Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells. J. Biol. Chem. 277 15393-9 PubMed GONUTS page

[PMID:26902720-2] 2.0 ^2.1 Mihara, E et al. (2016) Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. Elife 5 PubMed GONUTS page

[PMID:12610652-3] De Ferrari, GV et al. (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8 195-208 PubMed GONUTS page

[PMID:20371816-4] 4.0 ^4.1 ^4.2 Wisniewska, MB et al. (2010) LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J. Neurosci. 30 4957-69 PubMed GONUTS page

[PMID:19001373-5] Kress, E et al. (2009) The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine. J. Biol. Chem. 284 1234-41 PubMed GONUTS page

[PMID:22899650-6] 6.0 ^6.1 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page

[PMID:17244647-7] 7.0 ^7.1 ^7.2 Bryja, V et al. (2007) Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell. Sci. 120 586-95 PubMed GONUTS page

[PMID:14557550-8] 8.0 ^8.1 ^8.2 ^8.3 Castelo-Branco, G et al. (2003) Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl. Acad. Sci. U.S.A. 100 12747-52 PubMed GONUTS page

[PMID:17027228-9] 9.0 ^9.1 Bryja, V et al. (2007) Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin. Cell. Signal. 19 610-6 PubMed GONUTS page

[PMID:10557084-10] 10.0 ^10.1 ^10.2 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page

[PMID:24080158-11] Xavier, CP et al. (2014) Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell. Signal. 26 94-101 PubMed GONUTS page

[PMID:22723415-12] 12.0 ^12.1 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

[PMID:18929644-13] 13.0 ^13.1 ^13.2 Verkaar, F et al. (2009) Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell. Signal. 21 22-33 PubMed GONUTS page

[PMID:15265686-14] Lyons, JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp. Cell Res. 298 369-87 PubMed GONUTS page

[PMID:12121999-15] Holmen, SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J. Biol. Chem. 277 34727-35 PubMed GONUTS page

[PMID:12843296-16] 16.0 ^16.1 Viti, J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci. 23 5919-27 PubMed GONUTS page

[PMID:17569865-17] Bilic, J et al. (2007) Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316 1619-22 PubMed GONUTS page

[PMID:8167409-18] Smolich, BD et al. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol. Biol. Cell 4 1267-75 PubMed GONUTS page

[PMID:12897152-19] Liu, G et al. (2003) A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol. Cell. Biol. 23 5825-35 PubMed GONUTS page

[PMID:17994217-20] 20.0 ^20.1 ^20.2 ^20.3 Schinner, S et al. (2008) Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51 147-54 PubMed GONUTS page

[PMID:15454084-21] 21.0 ^21.1 ^21.2 ^21.3 Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page

[PMID:21539518-22] Pino, D et al. (2011) Wnt5a controls neurite development in olfactory bulb interneurons. ASN Neuro 3 e00059 PubMed GONUTS page

[PMID:16501258-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 Chen, J et al. (2006) Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation. J. Biol. Chem. 281 11910-6 PubMed GONUTS page

[PMID:21873635-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22665494-25] Arun, G et al. (2012) mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Mol. Cell. Biol. 32 3140-52 PubMed GONUTS page

[PMID:23740243-26] 26.0 ^26.1 ^26.2 Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page

[PMID:19896444-27] 27.0 ^27.1 Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page

[PMID:10893270-28] Toyofuku, T et al. (2000) Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J. Cell Biol. 150 225-41 PubMed GONUTS page

[PMID:18155657-29] Ouji, Y et al. (2008) Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem. Biophys. Res. Commun. 367 299-304 PubMed GONUTS page

[PMID:11029008-30] 30.0 ^30.1 Pinson, KI et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407 535-8 PubMed GONUTS page

[PMID:19901330-31] 31.0 ^31.1 Steele, BM et al. (2009) Canonical Wnt signaling negatively regulates platelet function. Proc. Natl. Acad. Sci. U.S.A. 106 19836-41 PubMed GONUTS page

[PMID:18716223-32] 32.0 ^32.1 ^32.2 ^32.3 ^32.4 Purro, SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J. Neurosci. 28 8644-54 PubMed GONUTS page

[PMID:19920076-33] 33.0 ^33.1 Yokoyama, N & Malbon, CC (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J. Cell. Sci. 122 4439-51 PubMed GONUTS page

[PMID:21554246-34] Yasuda, S et al. (2011) AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. Biochem. J. 437 345-55 PubMed GONUTS page

[PMID:19961844-35] 35.0 ^35.1 Alfieri, CM et al. (2010) Wnt signaling in heart valve development and osteogenic gene induction. Dev. Biol. 338 127-35 PubMed GONUTS page

[PMID:19910923-36] 36.0 ^36.1 Sato, A et al. (2010) Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J. 29 41-54 PubMed GONUTS page

[PMID:19699733-37] 37.0 ^37.1 ^37.2 Brack, AS et al. (2009) BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Dev. Biol. 335 93-105 PubMed GONUTS page

[PMID:16115200-38] 38.0 ^38.1 Takada, R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells 10 919-28 PubMed GONUTS page

[PMID:15143170-39] González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page

[PMID:10933391-40] 40.0 ^40.1 Reya, T et al. (2000) Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13 15-24 PubMed GONUTS page

[PMID:10409711-41] Lee, JS et al. (1999) Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J. Biol. Chem. 274 21464-70 PubMed GONUTS page

[PMID:19701191-42] Suriben, R et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat. Genet. 41 977-85 PubMed GONUTS page

[PMID:23677472-43] 43.0 ^43.1 Oderup, C et al. (2013) Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance. J. Immunol. 190 6126-34 PubMed GONUTS page

[PMID:19497282-44] Le Grand, F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4 535-47 PubMed GONUTS page

[PMID:19075000-45] Haÿ, E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol. Cell. Biol. 29 953-64 PubMed GONUTS page

[PMID:18606138-46] 46.0 ^46.1 Yamamoto, S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15 23-36 PubMed GONUTS page

[PMID:18555765-47] Olkku, A & Mahonen, A (2008) Wnt and steroid pathways control glutamate signalling by regulating glutamine synthetase activity in osteoblastic cells. Bone 43 483-93 PubMed GONUTS page

[PMID:17888405-48] 48.0 ^48.1 ^48.2 Kawai, M et al. (2007) Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem. Biophys. Res. Commun. 363 276-82 PubMed GONUTS page

[PMID:17462603-49] Wawrzak, D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun. 357 1119-23 PubMed GONUTS page

[PMID:16602827-50] Mikels, AJ & Nusse, R (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4 e115 PubMed GONUTS page

[PMID:16543246-51] Nam, JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J. Biol. Chem. 281 13247-57 PubMed GONUTS page

[PMID:15796911-52] 52.0 ^52.1 Kanazawa, A et al. (2005) Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Biochem. Biophys. Res. Commun. 330 505-10 PubMed GONUTS page

[PMID:15579909-53] Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page

[PMID:9126297-54] Yoshikawa, Y et al. (1997) Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev. Biol. 183 234-42 PubMed GONUTS page

[PMID:12717450-55] 55.0 ^55.1 ^55.2 Reya, T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423 409-14 PubMed GONUTS page

[PMID:17360443-56] Liu, Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 104 3859-64 PubMed GONUTS page

[PMID:9356179-57] Fan, CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev. Biol. 191 160-5 PubMed GONUTS page

[PMID:17251350-58] Mirotsou, M et al. (2007) Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc. Natl. Acad. Sci. U.S.A. 104 1643-8 PubMed GONUTS page

[PMID:15961523-59] Riccomagno, MM et al. (2005) Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev. 19 1612-23 PubMed GONUTS page

[PMID:8299937-60] 60.0 ^60.1 ^60.2 ^60.3 Takada, S et al. (1994) Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 8 174-89 PubMed GONUTS page

[PMID:17606995-61] Schwarz-Romond, T et al. (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J. Cell. Sci. 120 2402-12 PubMed GONUTS page

[PMID:15342465-62] Chu, EY et al. (2004) Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131 4819-29 PubMed GONUTS page

[PMID:19850029-63] Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page

[PMID:17943183-64] Bayle, J et al. (2008) Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J. Invest. Dermatol. 128 871-81 PubMed GONUTS page

[PMID:10631167-65] 65.0 ^65.1 Lee, SM et al. (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127 457-67 PubMed GONUTS page

[PMID:11877374-66] 66.0 ^66.1 Muroyama, Y et al. (2002) Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16 548-53 PubMed GONUTS page

[PMID:15148409-67] Satoh, K et al. (2004) Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc. Natl. Acad. Sci. U.S.A. 101 8017-21 PubMed GONUTS page

[PMID:19690384-68] Cohen, ED et al. (2009) Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J. Clin. Invest. 119 2538-49 PubMed GONUTS page

[PMID:16291790-69] 69.0 ^69.1 ^69.2 Nakaya, MA et al. (2005) Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development 132 5425-36 PubMed GONUTS page

[PMID:12636920-70] Aulehla, A et al. (2003) Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev. Cell 4 395-406 PubMed GONUTS page

[PMID:4819561-71] Grüneberg, H & Wickramaratne, GA (1974) A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J Embryol Exp Morphol 31 207-22 PubMed GONUTS page

[PMID:16581771-72] Si, W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol. Cell. Biol. 26 2955-64 PubMed GONUTS page

[PMID:16243425-73] Jankovic, J et al. () The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77 128-38 PubMed GONUTS page

[PMID:9889131-74] 74.0 ^74.1 ^74.2 ^74.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page

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MOUSE:WNT3A

Contents

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