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PMID:10631167
| Citation |
Lee, SM, Tole, S, Grove, E and McMahon, AP (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127:457-67 |
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| Abstract |
The mechanisms that regulate patterning and growth of the developing cerebral cortex remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes are expressed in selective patterns in the embryonic cortex. We have examined the role of Wnt-3a signaling at the caudomedial margin of the developing cerebral cortex, the site of hippocampal development. We show that Wnt-3a acts locally to regulate the expansion of the caudomedial cortex, from which the hippocampus develops. In mice lacking Wnt-3a, caudomedial cortical progenitor cells appear to be specified normally, but then underproliferate. By mid-gestation, the hippocampus is missing or represented by tiny populations of residual hippocampal cells. Thus, Wnt-3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development. |
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| Keywords |
Animals; Cerebral Cortex/embryology; Embryonic and Fetal Development/physiology; Gene Expression Regulation, Developmental; Gestational Age; Hippocampus/embryology; Mammals; Mice; Mice, Knockout; Neurons/cytology; Neurons/physiology; Proteins/genetics; Proteins/physiology; Signal Transduction/physiology; Stem Cells/cytology; Stem Cells/physiology; Telencephalon/embryology; Wnt Proteins; Wnt3 Protein; Wnt3A Protein |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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