GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

Category:GO:1990909 ! Wnt signalosome

Jump to: navigation, search

DAG for GO:1990909id: GO:1990909

name: Wnt signalosome
namespace: cellular_component
def: "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]
comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
synonym: "LRP5/6 signalosome" EXACT [GOC:bf]
synonym: "LRP6 signalosome" NARROW [PMID:22899650, PMID:25074807]
synonym: "Wnt signalosome complex" EXACT [PMID:24412065]
synonym: "Wnt-LRP5/6 signalosome" EXACT [PMID:23892894]
is_a: GO:0032991 ! protein-containing complex
relationship: has_part: GO:1990851 ! Wnt-Frizzled-LRP5/6 complex

AmiGO <GOterm>GO:1990909</GOterm>
Gene Ontology Home

The contents of this box are automatically generated. You can help by adding information to the "Notes"

Usage Notes


See Help:References for how to manage references in GONUTS.

Pages in category "GO:1990909 ! Wnt signalosome"

The following 20 pages are in this category, out of 20 total.

Jump to pages starting with: H M P