name: Wnt signalosome
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def: "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]
comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
synonym: "LRP5/6 signalosome" EXACT [GOC:bf]
synonym: "LRP6 signalosome" NARROW [PMID:22899650, PMID:25074807]
synonym: "Wnt signalosome complex" EXACT [PMID:24412065]
synonym: "Wnt-LRP5/6 signalosome" EXACT [PMID:23892894]
is_a: GO:0032991 ! protein-containing complex
relationship: has_part: GO:1990851 ! Wnt-Frizzled-LRP5/6 complex
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