HUMAN:GSK3B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GSK3B
Protein Name(s)	Glycogen synthase kinase-3 beta GSK-3 beta Serine/threonine-protein kinase GSK3B
External Links
UniProt	P49841
EMBL	L33801 CH471052 CH471052 BC000251 BC012760 AF074333 AF098789
CCDS	CCDS2996.1 CCDS54628.1
PIR	S53324
RefSeq	NP_001139628.1 NP_002084.2
UniGene	Hs.445733
PDB	1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3MV5 3OW4 3PUP 3Q3B 3QKK 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71 4NM0 4NM3 4NM5 4NM7
PDBsum	1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3MV5 3OW4 3PUP 3Q3B 3QKK 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71 4NM0 4NM3 4NM5 4NM7
DisProt	DP00385
ProteinModelPortal	P49841
SMR	P49841
BioGrid	109187
DIP	DIP-878N
IntAct	P49841
MINT	MINT-105006
STRING	9606.ENSP00000324806
BindingDB	P49841
ChEMBL	CHEMBL2095188
DrugBank	DB01356
GuidetoPHARMACOLOGY	2030
PhosphoSite	P49841
DMDM	20455502
MaxQB	P49841
PaxDb	P49841
PRIDE	P49841
DNASU	2932
Ensembl	ENST00000264235 ENST00000316626
GeneID	2932
KEGG	hsa:2932
UCSC	uc003edn.3 uc003edo.3
CTD	2932
GeneCards	GC03M119540
HGNC	HGNC:4617
HPA	CAB016263 HPA028017
MIM	605004
neXtProt	NX_P49841
PharmGKB	PA29009
eggNOG	COG0515
GeneTree	ENSGT00520000055635
HOGENOM	HOG000233017
HOVERGEN	HBG014652
InParanoid	P49841
KO	K03083
OMA	NAGERVQ
OrthoDB	EOG7TF78V
PhylomeDB	P49841
TreeFam	TF101104
BRENDA	2.7.11.26
Reactome	REACT_11063 REACT_11065 REACT_12564 REACT_147727 REACT_19199 REACT_200610 REACT_200780 REACT_206597 REACT_228060 REACT_228137 REACT_228159 REACT_228196 REACT_228251 REACT_228261 REACT_228285 REACT_228314 REACT_231645
SignaLink	P49841
ChiTaRS	GSK3B
EvolutionaryTrace	P49841
GeneWiki	GSK3B
GenomeRNAi	2932
NextBio	11619
PRO	PR:P49841
Proteomes	UP000005640
Bgee	P49841
CleanEx	HS_GSK3B
ExpressionAtlas	P49841
Genevestigator	P49841
GO	GO:0030877 GO:0005813 GO:0005737 GO:0005829 GO:0043198 GO:0043197 GO:0030426 GO:0045121 GO:0043025 GO:0005634 GO:0048471 GO:0005886 GO:0030529 GO:0005524 GO:0008013 GO:0016301 GO:0051059 GO:0002039 GO:0034236 GO:0019901 GO:0004674 GO:0001085 GO:0050321 GO:0031625 GO:0007411 GO:0060070 GO:0044337 GO:0016477 GO:0036016 GO:0071260 GO:0007623 GO:0007173 GO:0001837 GO:0006983 GO:0030010 GO:0097192 GO:0045444 GO:0038095 GO:0008543 GO:0005977 GO:0021766 GO:0044027 GO:0045087 GO:0035556 GO:0007520 GO:0043066 GO:0090090 GO:0010614 GO:0050774 GO:2000466 GO:0045719 GO:0043407 GO:0014043 GO:0051534 GO:0032091 GO:0031333 GO:2000077 GO:0048011 GO:0009887 GO:0018105 GO:0048015 GO:0001954 GO:1901030 GO:0033138 GO:0010800 GO:0032436 GO:0032092 GO:0045732 GO:0031334 GO:0046827 GO:0032855 GO:2000738 GO:0045944 GO:0006611 GO:0035372 GO:0006468 GO:0000320 GO:0006349 GO:0032886 GO:0048168 GO:0042493 GO:0010226 GO:0071109
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005737	cytoplasm	PMID:17139249^[1]	ECO:0000314			C		Fig.1A …endogenous GSK-3b were mainly diffusely distributed throughout the cytoplasm….	complete
	GO:0005813	centrosome	PMID:17139249^[1]	ECO:0000314			C		Fig.1A …. Arrows indicate centrosomal GSK-3b..	complete
	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:17139249^[1]	ECO:0000315			P		Fig.1C,D Microtubules no longer appeared to radiate from the perinuclear focus in GSK-3b knockdown cells….	complete
NOT	GO:0010968	regulation of microtubule nucleation	PMID:17139249^[1]	ECO:0000315			P		Fig.2 …..Knockdown of GSK-3a did not affect the nucleation and anchoring of the microtubules…	complete
	GO:0034454	microtubule anchoring at centrosome	PMID:17139249^[1]	ECO:0000315			P		Fig.2 GSK-3b knockdown cells decreased the centrosome-bound microtubules….	complete
	GO:0005515	protein binding	PMID:17139249^[1]	ECO:0000021		UniProtKB:Q96G01	F		Fig.3B,6A .. GSK-3b and BICD1 form a complex…	complete
	GO:0042325	regulation of phosphorylation	PMID:17139249^[1]	ECO:0000315			P		Fig.7B The extent of the phosphorylation level of BICD1 in GSK-3b knockdown cells metabolically labeled with 32P was reduced as compared with that of the control cells.	complete
	GO:0032880	regulation of protein localization	PMID:17139249^[1]	ECO:0000315			P		Fig.8B …the amounts of ninein at the centrosome.. were indeed decreased in GSK-3b…knockdown cells..	complete
	GO:0005515	protein binding	PMID:21118991^[2]	ECO:0000021		UniProtKB:O95071	F		Co-immunoprecipitation between GSK-3 and EDD Fig 1E – Pulldown GSK-3β bound EDD	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:25897075^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q6R327)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28386764^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:25897075^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q6R327)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16981698^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9P0R6)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16981698^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9P0R6)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:16981698^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(UniProtKB:Q9P0R6)	Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91757	P		Seeded From UniProt	complete
involved_in	GO:1901984	negative regulation of protein acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P	regulates_o_occurs_in:(CL:0002608) regulates_o_occurs_in:(GO:0015630)	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P	regulates_o_occurs_in:(GO:0030424) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:28386764^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P	part_of:(GO:0071549)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P	regulates_expression_of:(ENSEMBL:ENSG00000113580)	Seeded From UniProt	complete
involved_in	GO:1904781	positive regulation of protein localization to centrosome	PMID:17139249^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96G01)	Seeded From UniProt	complete
enables	GO:0034452	dynactin binding	PMID:17139249^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13561 UniProtKB:Q14203	F		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:17139249^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates:(GO:0034454)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8725894^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010822	positive regulation of mitochondrion organization	PMID:25118933^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:25118933^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43464	F		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:17139249^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P	causally_upstream_of:(GO:0071902) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21711983^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904781	positive regulation of protein localization to centrosome	PMID:17139249^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q8N4C6) regulates:(GO:0000226)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:17139249^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q96G01) regulates:(GO:0000226) regulates:(GO:0045505)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:17139249^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q96G01) regulates:(GO:0000226) regulates:(GO:0045505)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17139249^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q96G01) regulates:(GO:0000226) regulates:(GO:0045505)	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:19830702^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:19830702^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:18508033^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16315267^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16315267^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:11955436^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P35222) occurs_in:(GO:0030877)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11955436^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P35222) occurs_in:(GO:0030877)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:11955436^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P35222) occurs_in:(GO:0030877)	Seeded From UniProt	complete
involved_in	GO:1900181	negative regulation of protein localization to nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11955436^[12]	ECO:0000305	curator inference used in manual assertion	GO:0004674	P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:11955436^[12]	ECO:0000305	curator inference used in manual assertion	GO:0004674	P	has_regulation_target:(UniProtKB:P35222)	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:24391509^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0106027	neuron projection organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0030011	maintenance of cell polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	C		Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P		Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:23184662^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071109	superior temporal gyrus development	PMID:19581563^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:16365045^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:16188939^[17]	ECO:0000305	curator inference used in manual assertion	GO:0030877	P		Seeded From UniProt	complete
enables	GO:0034236	protein kinase A catalytic subunit binding	PMID:11035810^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17612	F		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:18156211^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:16890161^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O15169) has_regulation_target:(UniProtKB:O75581)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21118991^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95071	F		Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	PMID:8638126^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031333	negative regulation of protein complex assembly	PMID:16188939^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:16188939^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:8638126^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	PMID:19581563^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:8638126^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:8638126^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11035810^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	PMID:8638126^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19038973^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18787224^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11035810^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8638126^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	F		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	PMID:18156211^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	PMID:21711983^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0099565)	Seeded From UniProt	complete
involved_in	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:9601641^[24]	ECO:0000305	curator inference used in manual assertion	GO:0030877	P		Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	PMID:9072970^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:15465828^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:14690523^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0036016	cellular response to interleukin-3	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0032886	regulation of microtubule-based process	PMID:20937854^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:16188939^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:9601641^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:18348280^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P57059	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:15448698^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV60	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:20937854^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20937854^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21399614^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20937854^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15448698^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15448698^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18348280^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9072970^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:15448698^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:20864106^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92908	F		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:17989287^[33]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:17989287^[33]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:17989287^[33]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:17989287^[33]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:17989287^[33]	ECO:0005581	enzyme-linked immunoabsorbent assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17989287^[33]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17989287^[33]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17989287^[33]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17989287^[33]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17989287^[33]	ECO:0005581	enzyme-linked immunoabsorbent assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:14749367^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:11104755^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006983	ER overload response	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11104755^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:14744935^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1901030	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR033573	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.26	F		Seeded From UniProt	complete
involved_in	GO:0032515	negative regulation of phosphoprotein phosphatase activity	PMID:28386764^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P67775)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:26049140^[37] PMID:24115276^[38] PMID:22988876^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_input:(UniProtKB:P35222) part_of:(GO:0060070)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:26049140^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P35222)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:26049140^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P35222) part_of:(GO:0060070)	Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:24115276^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904339	negative regulation of dopaminergic neuron differentiation	PMID:24431302^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:11955436^[12] PMID:19366350^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	PMID:18268107^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0030011	maintenance of cell polarity	PMID:18268107^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:2000466	negative regulation of glycogen (starch) synthase activity	PMID:19366350^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000077	negative regulation of type B pancreatic cell development	PMID:19366350^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19366350^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045719	negative regulation of glycogen biosynthetic process	PMID:19366350^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904885	beta-catenin destruction complex assembly	Reactome:R-HSA-195251	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-195300 Reactome:R-HSA-195287 Reactome:R-HSA-195283	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-209146 Reactome:R-NUL-1458902 Reactome:R-HSA-5610732 Reactome:R-HSA-5368596 Reactome:R-HSA-5339713 Reactome:R-HSA-5323526 Reactome:R-HSA-5229343 Reactome:R-HSA-4839746 Reactome:R-HSA-4839734 Reactome:R-HSA-4839638 Reactome:R-HSA-4839635 Reactome:R-HSA-4839634 Reactome:R-HSA-4827388 Reactome:R-HSA-4791278 Reactome:R-HSA-399951 Reactome:R-HSA-3371435 Reactome:R-HSA-2399966 Reactome:R-HSA-2130286 Reactome:R-HSA-2130282 Reactome:R-HSA-2130279 Reactome:R-HSA-201685 Reactome:R-HSA-201677 Reactome:R-HSA-195318 Reactome:R-HSA-195304 Reactome:R-HSA-195300 Reactome:R-HSA-195287 Reactome:R-HSA-195283 Reactome:R-HSA-195280 Reactome:R-HSA-195275 Reactome:R-HSA-195251 Reactome:R-HSA-1504186	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9008636 Reactome:R-NUL-9008555	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-NUL-9008636 Reactome:R-NUL-209146 Reactome:R-HSA-5610732 Reactome:R-HSA-399951 Reactome:R-HSA-3371435 Reactome:R-HSA-201677	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0321	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page
↑ ^2.0 ^2.1 Hay-Koren, A et al. (2011) The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol. Biol. Cell 22 399-411 PubMed GONUTS page
↑ ^3.0 ^3.1 Koo, J et al. (2015) Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J. Biol. Chem. 290 14120-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Chou, HY et al. (2006) GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. Biochemistry 45 11379-89 PubMed GONUTS page
↑ Harr, SD et al. () Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. Neurobiol. Aging 17 343-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Xu, R et al. (2014) The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis 5 e1373 PubMed GONUTS page
↑ ^8.0 ^8.1 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page
↑ ^9.0 ^9.1 Lin, CC et al. (2009) GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells. J. Cell. Biochem. 108 1325-36 PubMed GONUTS page
↑ Chen, YY et al. (2008) GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. Biochem. Pharmacol. 76 128-38 PubMed GONUTS page
↑ ^11.0 ^11.1 Kwok, JB et al. (2005) GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Ann. Neurol. 58 829-39 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Liu, C et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108 837-47 PubMed GONUTS page
↑ Suenaga, Y et al. (2014) NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas. PLoS Genet. 10 e1003996 PubMed GONUTS page
↑ Hizli, AA et al. (2013) Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Mol. Cell. Biol. 33 596-604 PubMed GONUTS page
↑ ^15.0 ^15.1 Inkster, B et al. (2009) Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder. Arch. Gen. Psychiatry 66 721-8 PubMed GONUTS page
↑ Mi, K et al. (2006) The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity. J. Biol. Chem. 281 4787-94 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Fang, X et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97 11960-5 PubMed GONUTS page
↑ ^19.0 ^19.1 Dufourcq, P et al. (2008) Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. Am. J. Pathol. 172 37-49 PubMed GONUTS page
↑ Yamamoto, H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 11 213-23 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Rubinfeld, B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-6 PubMed GONUTS page
↑ Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page
↑ Gelebart, P et al. (2008) Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood 112 5171-9 PubMed GONUTS page
↑ ^24.0 ^24.1 Hart, MJ et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8 573-81 PubMed GONUTS page
↑ ^25.0 ^25.1 Beals, CR et al. (1997) Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275 1930-4 PubMed GONUTS page
↑ Buss, H et al. (2004) Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J. Biol. Chem. 279 49571-4 PubMed GONUTS page
↑ Cho, JH & Johnson, GV (2004) Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules. J. Neurochem. 88 349-58 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Zaoui, K et al. (2010) ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl. Acad. Sci. U.S.A. 107 18517-22 PubMed GONUTS page
↑ ^29.0 ^29.1 Hashimoto, YK et al. (2008) Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. J. Cell. Biochem. 104 1724-39 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 Zhou, BP et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6 931-40 PubMed GONUTS page
↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
↑ Tsoyi, K et al. (2010) PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells. Atherosclerosis 213 115-21 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 ^33.7 ^33.8 ^33.9 Zhu, LQ et al. (2007) Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J. Neurosci. 27 12211-20 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 ^34.4 ^34.5 ^34.6 ^34.7 Qu, L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18 261-77 PubMed GONUTS page
↑ Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page
↑ ^36.0 ^36.1 Kirschenbaum, F et al. (2001) Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling. J. Biol. Chem. 276 7366-75 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Zhang, J et al. (2015) A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol. Dis. 82 32-45 PubMed GONUTS page
↑ ^38.0 ^38.1 Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page
↑ Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 ^41.3 ^41.4 Rayasam, GV et al. (2009) Glycogen synthase kinase 3: more than a namesake. Br. J. Pharmacol. 156 885-98 PubMed GONUTS page
↑ ^42.0 ^42.1 Witte, H et al. (2008) Microtubule stabilization specifies initial neuronal polarization. J. Cell Biol. 180 619-32 PubMed GONUTS page

[PMID:17139249-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Fumoto, K et al. (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25 5670-82 PubMed GONUTS page

[PMID:21118991-2] 2.0 ^2.1 Hay-Koren, A et al. (2011) The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol. Biol. Cell 22 399-411 PubMed GONUTS page

[PMID:25897075-3] 3.0 ^3.1 Koo, J et al. (2015) Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J. Biol. Chem. 290 14120-9 PubMed GONUTS page

[PMID:28386764-4] 4.0 ^4.1 ^4.2 ^4.3 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:16981698-5] 5.0 ^5.1 ^5.2 Chou, HY et al. (2006) GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. Biochemistry 45 11379-89 PubMed GONUTS page

[PMID:8725894-6] Harr, SD et al. () Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. Neurobiol. Aging 17 343-8 PubMed GONUTS page

[PMID:25118933-7] 7.0 ^7.1 Xu, R et al. (2014) The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis 5 e1373 PubMed GONUTS page

[PMID:21711983-8] 8.0 ^8.1 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page

[PMID:19830702-9] 9.0 ^9.1 Lin, CC et al. (2009) GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells. J. Cell. Biochem. 108 1325-36 PubMed GONUTS page

[PMID:18508033-10] Chen, YY et al. (2008) GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. Biochem. Pharmacol. 76 128-38 PubMed GONUTS page

[PMID:16315267-11] 11.0 ^11.1 Kwok, JB et al. (2005) GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Ann. Neurol. 58 829-39 PubMed GONUTS page

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[PMID:24391509-13] Suenaga, Y et al. (2014) NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas. PLoS Genet. 10 e1003996 PubMed GONUTS page

[PMID:23184662-14] Hizli, AA et al. (2013) Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Mol. Cell. Biol. 33 596-604 PubMed GONUTS page

[PMID:19581563-15] 15.0 ^15.1 Inkster, B et al. (2009) Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder. Arch. Gen. Psychiatry 66 721-8 PubMed GONUTS page

[PMID:16365045-16] Mi, K et al. (2006) The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity. J. Biol. Chem. 281 4787-94 PubMed GONUTS page

[PMID:16188939-17] 17.0 ^17.1 ^17.2 ^17.3 Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page

[PMID:11035810-18] 18.0 ^18.1 ^18.2 Fang, X et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97 11960-5 PubMed GONUTS page

[PMID:18156211-19] 19.0 ^19.1 Dufourcq, P et al. (2008) Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. Am. J. Pathol. 172 37-49 PubMed GONUTS page

[PMID:16890161-20] Yamamoto, H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 11 213-23 PubMed GONUTS page

[PMID:8638126-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Rubinfeld, B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-6 PubMed GONUTS page

[PMID:19038973-22] Wang, HX et al. (2009) Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol. Hum. Reprod. 15 11-7 PubMed GONUTS page

[PMID:18787224-23] Gelebart, P et al. (2008) Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood 112 5171-9 PubMed GONUTS page

[PMID:9601641-24] 24.0 ^24.1 Hart, MJ et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8 573-81 PubMed GONUTS page

[PMID:9072970-25] 25.0 ^25.1 Beals, CR et al. (1997) Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275 1930-4 PubMed GONUTS page

[PMID:15465828-26] Buss, H et al. (2004) Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J. Biol. Chem. 279 49571-4 PubMed GONUTS page

[PMID:14690523-27] Cho, JH & Johnson, GV (2004) Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules. J. Neurochem. 88 349-58 PubMed GONUTS page

[PMID:20937854-28] 28.0 ^28.1 ^28.2 ^28.3 Zaoui, K et al. (2010) ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl. Acad. Sci. U.S.A. 107 18517-22 PubMed GONUTS page

[PMID:18348280-29] 29.0 ^29.1 Hashimoto, YK et al. (2008) Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. J. Cell. Biochem. 104 1724-39 PubMed GONUTS page

[PMID:15448698-30] 30.0 ^30.1 ^30.2 ^30.3 Zhou, BP et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6 931-40 PubMed GONUTS page

[PMID:21399614-31] Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page

[PMID:20864106-32] Tsoyi, K et al. (2010) PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells. Atherosclerosis 213 115-21 PubMed GONUTS page

[PMID:17989287-33] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 ^33.7 ^33.8 ^33.9 Zhu, LQ et al. (2007) Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J. Neurosci. 27 12211-20 PubMed GONUTS page

[PMID:14744935-34] 34.0 ^34.1 ^34.2 ^34.3 ^34.4 ^34.5 ^34.6 ^34.7 Qu, L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18 261-77 PubMed GONUTS page

[PMID:14749367-35] Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page

[PMID:11104755-36] 36.0 ^36.1 Kirschenbaum, F et al. (2001) Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling. J. Biol. Chem. 276 7366-75 PubMed GONUTS page

[PMID:26049140-37] 37.0 ^37.1 ^37.2 Zhang, J et al. (2015) A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol. Dis. 82 32-45 PubMed GONUTS page

[PMID:24115276-38] 38.0 ^38.1 Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page

[PMID:22988876-39] Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

[PMID:24431302-40] Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

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[PMID:18268107-42] 42.0 ^42.1 Witte, H et al. (2008) Microtubule stabilization specifies initial neuronal polarization. J. Cell Biol. 180 619-32 PubMed GONUTS page

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HUMAN:GSK3B

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