HUMAN:WNT3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	WNT3 (synonyms: INT4)
Protein Name(s)	Proto-oncogene Wnt-3 Proto-oncogene Int-4 homolog
External Links
UniProt	P56703
EMBL	AY009397 AB067628 BC112116 BC112118 BC114219
CCDS	CCDS11505.1
PIR	A47536
RefSeq	NP_110380.1
UniGene	Hs.445884 Hs.745220
ProteinModelPortal	P56703
SMR	P56703
BioGrid	113310
IntAct	P56703
STRING	9606.ENSP00000225512
BindingDB	P56703
ChEMBL	CHEMBL6079
PhosphoSite	P56703
DMDM	14424477
PaxDb	P56703
PRIDE	P56703
DNASU	7473
Ensembl	ENST00000225512 ENST00000611547 ENST00000616347
GeneID	7473
KEGG	hsa:7473
UCSC	uc002ikv.3
CTD	7473
GeneCards	GC17M044839
GeneReviews	WNT3
HGNC	HGNC:12782
MIM	165330 273395
neXtProt	NX_P56703
Orphanet	3301
PharmGKB	PA37383
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039529
HOVERGEN	HBG001595
InParanoid	P56703
KO	K00312
OMA	MCGCDSH
OrthoDB	EOG7C8GJ8
PhylomeDB	P56703
TreeFam	TF105310
Reactome	REACT_163710 REACT_18372 REACT_200777
GeneWiki	WNT3
GenomeRNAi	7473
NextBio	29272
PRO	PR:P56703
Proteomes	UP000005640 UP000005640
Bgee	P56703
CleanEx	HS_WNT3
Genevestigator	P56703
GO	GO:0005788 GO:0005576 GO:0005615 GO:0005796 GO:0005886 GO:0005578 GO:0005109 GO:0048018 GO:0009948 GO:0007411 GO:0060070 GO:0044338 GO:0044339 GO:0045165 GO:0000902 GO:0071300 GO:0009950 GO:0035115 GO:0035116 GO:0007276 GO:0060323 GO:0060174 GO:0061180 GO:0001707 GO:0048843 GO:0030182 GO:0048697 GO:0010628 GO:0060064
InterPro	IPR005817 IPR009141 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01843 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1905474	canonical Wnt signaling pathway involved in stem cell proliferation	PMID:25640183^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:1904948)	Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	PMID:25640183^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072089	stem cell proliferation	PMID:25640183^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0008543)	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:28733458^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25640183^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000162761)	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	PMID:25640183^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:24115276^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:10557084^[4]	ECO:0000305	curator inference used in manual assertion	GO:0048018 GO:0060070	C		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:10557084^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0016055)	Seeded From UniProt	complete
involved_in	GO:0060174	limb bud formation	PMID:14872406^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15588944^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18044981^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:18044981^[7]	ECO:0000305	curator inference used in manual assertion	GO:0060070	F		Seeded From UniProt	complete
involved_in	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation	PMID:20039315^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044338	canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	PMID:20039315^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:18313787^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75084	F		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:15588944^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
involved_in	GO:0061180	mammary gland epithelium development	PMID:8168088^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:10557084^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56706	P		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:10557084^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UP38	F		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZCR1 ensembl:ENSRNOP00000005176	C		Seeded From UniProt	complete
involved_in	GO:0060323	head morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0060064	Spemann organizer formation at the anterior end of the primitive streak	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0048843	negative regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0048697	positive regulation of collateral sprouting in absence of injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	C		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0007276	gamete generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17553 ensembl:ENSMUSP00000000127	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:24115276^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18313787^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3781941	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3781943 Reactome:R-HSA-3247844 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-3247844 Reactome:R-HSA-3247840 Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-3247837	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5323545 Reactome:R-HSA-3247843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lee, CT et al. (2015) Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation. Cell Rep 10 616-32 PubMed GONUTS page
↑ ^2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
↑ ^3.0 ^3.1 Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page
↑ Niemann, S et al. (2004) Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am. J. Hum. Genet. 74 558-63 PubMed GONUTS page
↑ ^6.0 ^6.1 Chiba, H et al. (2004) Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. Exp. Hematol. 32 1194-203 PubMed GONUTS page
↑ ^7.0 ^7.1 Björklund, P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 4 e328 PubMed GONUTS page
↑ ^8.0 ^8.1 Bhat, RA et al. (2010) Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. J. Cell. Biochem. 109 876-84 PubMed GONUTS page
↑ ^9.0 ^9.1 Kim, M et al. (2008) Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J. Hepatol. 48 780-91 PubMed GONUTS page
↑ Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25640183-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lee, CT et al. (2015) Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation. Cell Rep 10 616-32 PubMed GONUTS page

[PMID:28733458-2] 2.0 ^2.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page

[PMID:24115276-3] 3.0 ^3.1 Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page

[PMID:10557084-4] 4.0 ^4.1 ^4.2 ^4.3 Gazit, A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18 5959-66 PubMed GONUTS page

[PMID:14872406-5] Niemann, S et al. (2004) Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am. J. Hum. Genet. 74 558-63 PubMed GONUTS page

[PMID:15588944-6] 6.0 ^6.1 Chiba, H et al. (2004) Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. Exp. Hematol. 32 1194-203 PubMed GONUTS page

[PMID:18044981-7] 7.0 ^7.1 Björklund, P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 4 e328 PubMed GONUTS page

[PMID:20039315-8] 8.0 ^8.1 Bhat, RA et al. (2010) Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. J. Cell. Biochem. 109 876-84 PubMed GONUTS page

[PMID:18313787-9] 9.0 ^9.1 Kim, M et al. (2008) Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J. Hepatol. 48 780-91 PubMed GONUTS page

[PMID:8168088-10] Huguet, EL et al. (1994) Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54 2615-21 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:WNT3

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