HUMAN:APC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	APC (synonyms: DP2.5)
Protein Name(s)	Adenomatous polyposis coli protein Protein APC Deleted in polyposis 2.5
External Links
UniProt	P25054
EMBL	M73548 M73548 M74088 CH471086 CH471086 S78214
CCDS	CCDS4107.1
PIR	A37261
RefSeq	NP_000029.2 NP_001120982.1
UniGene	Hs.158932
PDB	1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69
PDBsum	1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69
DisProt	DP00519
ProteinModelPortal	P25054
SMR	P25054
BioGrid	106821
DIP	DIP-33556N
IntAct	P25054
MINT	MINT-88204
STRING	9606.ENSP00000257430
PhosphoSite	P25054
DMDM	97535708
MaxQB	P25054
PaxDb	P25054
PRIDE	P25054
DNASU	324
Ensembl	ENST00000257430 ENST00000508376
GeneID	324
KEGG	hsa:324
UCSC	uc003kpy.4
CTD	324
GeneCards	GC05P112101
GeneReviews	APC
HGNC	HGNC:583
HPA	CAB025994 HPA013349
MIM	114550 135290 155255 175100 276300 611731 613659
neXtProt	NX_P25054
Orphanet	247806 873 261584 79665 99818
PharmGKB	PA24875
eggNOG	NOG259696
GeneTree	ENSGT00530000063749
HOVERGEN	HBG004264
InParanoid	P25054
KO	K02085
OMA	IEDCPIN
PhylomeDB	P25054
TreeFam	TF106496
BioCyc	MetaCyc:ENSG00000134982-MONOMER
Reactome	REACT_107 REACT_11063 REACT_11065 REACT_200610 REACT_200731 REACT_228060 REACT_228137 REACT_228143 REACT_228159 REACT_228196 REACT_228251 REACT_228261 REACT_228285 REACT_228314
SignaLink	P25054
ChiTaRS	APC
EvolutionaryTrace	P25054
GeneWiki	Adenomatous_polyposis_coli
GenomeRNAi	324
NextBio	1329
PRO	PR:P25054
Proteomes	UP000005640
Bgee	P25054
CleanEx	HS_APC
ExpressionAtlas	P25054
Genevestigator	P25054
GO	GO:0005912 GO:0044295 GO:0030877 GO:0005813 GO:0005737 GO:0005881 GO:0005829 GO:0000776 GO:0030027 GO:0016328 GO:0035371 GO:0005634 GO:0005886 GO:0032587 GO:0005923 GO:0008013 GO:0045295 GO:0008017 GO:0051010 GO:0019901 GO:0019887 GO:0009952 GO:0006915 GO:0009798 GO:0007409 GO:0060070 GO:0044336 GO:0044337 GO:0007155 GO:0007050 GO:0016477 GO:0006921 GO:0006974 GO:0051276 GO:0031122 GO:0009953 GO:0001942 GO:0001822 GO:0007091 GO:0000281 GO:0007094 GO:0046716 GO:0090090 GO:0008285 GO:0045736 GO:0060770 GO:0043409 GO:0007026 GO:0042483 GO:0043065 GO:0045785 GO:0051781 GO:0030335 GO:0030858 GO:0031116 GO:0045732 GO:0031274 GO:0006461 GO:0009954 GO:0051988 GO:0032886 GO:0051171 GO:0045667 GO:0045670 GO:0060041 GO:0035019 GO:0033077 GO:0048538 GO:0070830
Gene3D	1.25.10.10
InterPro	IPR026836 IPR009240 IPR009234 IPR009223 IPR026831 IPR026818 IPR011989 IPR016024 IPR000225 IPR009232 IPR009224
PANTHER	PTHR12607 PTHR12607:SF11
Pfam	PF05972 PF05956 PF05923 PF00514 PF05937 PF05924 PF11414
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26948948^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61315	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:7806582^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:16344550^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:28057765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904781	positive regulation of protein localization to centrosome	PMID:28057765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(GO:0030286)	Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:28057765^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A0A0D9RCF4	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:28057765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:28057765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	PMID:28057765^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:28057765^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:16753179^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:24115276^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:7806582^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:16188939^[7]	ECO:0000305	curator inference used in manual assertion	GO:0030877	P		Seeded From UniProt	complete
NOT\|enables	GO:0045296	cadherin binding	PMID:7890674^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	PMID:7890674^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14923	F		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:16188939^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:8638126^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:7890674^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:9707618^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	PMID:16611247^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	PMID:18502210^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:9601641^[13]	ECO:0000305	curator inference used in manual assertion	GO:0030877	P		Seeded From UniProt	complete
involved_in	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:11283619^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	PMID:19632184^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:8521819^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032886	regulation of microtubule-based process	PMID:20937854^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	PMID:19151759^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:16188939^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:9601641^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:19151759^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8638126^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0019887	protein kinase regulator activity	PMID:11972058^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:19151759^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:8521819^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:16188939^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:11166179^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:11533658^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:10773885^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:8259518^[23]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:8521819^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	PMID:11166179^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:14728717^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:16188939^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:18502210^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005913	cell-cell adherens junction	PMID:16611247^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20937854^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:11283619^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20937854^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11035805^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12955080^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12955080^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11035805^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:11283619^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996 UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612	P		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288612 UniProtKB:P25054	F		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 PANTHER:PTN000288612 UniProtKB:P25054	C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996 UniProtKB:P25054 WB:WBGene00000156	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996	C		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288612 WB:WBGene00000156	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12952940^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41221	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12952940^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O43255	P		Seeded From UniProt	complete
involved_in	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:17227893^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:18076571^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41221	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O43255	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17227893^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18076571^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031274	positive regulation of pseudopodium assembly	PMID:17192415^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17192415^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:12072559^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	PMID:17227893^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	PMID:17192415^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12072559^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:17570218^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21471006^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009240 InterPro:IPR026818 InterPro:IPR026836	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009234	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009223 InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009234 InterPro:IPR009240	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026818 InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:1904886	beta-catenin destruction complex disassembly	Reactome:R-HSA-4641262	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904885	beta-catenin destruction complex assembly	Reactome:R-HSA-195251	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	Reactome:R-HSA-195721	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-209144 Reactome:R-NUL-209132 Reactome:R-NUL-209065 Reactome:R-NUL-209060 Reactome:R-HSA-6781905 Reactome:R-HSA-5339713 Reactome:R-HSA-5246696 Reactome:R-HSA-5246693 Reactome:R-HSA-5229343 Reactome:R-HSA-4839746 Reactome:R-HSA-4839734 Reactome:R-HSA-4839638 Reactome:R-HSA-4839635 Reactome:R-HSA-4839634 Reactome:R-HSA-4827388 Reactome:R-HSA-4791278 Reactome:R-HSA-2130286 Reactome:R-HSA-2130282 Reactome:R-HSA-2130279 Reactome:R-HSA-202947 Reactome:R-HSA-201685 Reactome:R-HSA-195318 Reactome:R-HSA-195304 Reactome:R-HSA-195300 Reactome:R-HSA-195287 Reactome:R-HSA-195283 Reactome:R-HSA-195280 Reactome:R-HSA-195275 Reactome:R-HSA-195251	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-3364042 Reactome:R-HSA-3361751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0301	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
Contributes to	GO:0007076	mitotic chromosome condensation	PMID:22719865^[35]	ECO:0000314			P		APC depletion increases chromatin condensation in HeLa cells.	complete
	GO:0016342	catenin complex	PMID:7806582^[2]	ECO:0000314			C		Fig 5c lane 2 shows bindig of alpha catenin and formation of a catenin complex	complete CACAO 2914
	GO:0006461	protein complex assembly	PMID:16188939^[7]	ECO:0000314			P		Figure 6 shows Neuroligin surface cluseters are decreased in dn- expressubg in CG neurons. Figure 6 also shows how APC works in unison with Beta-Cat and S-Scam to decrease NL sypnatic accumulation.	complete CACAO 6384
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Liu, Z et al. (2016) Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Mol. Cell. Endocrinol. 427 57-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Hülsken, J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 2061-9 PubMed GONUTS page
↑ Yang, CK et al. (2006) Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J. Biol. Chem. 281 3389-97 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gao, FJ et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol. Biol. Cell 28 587-599 PubMed GONUTS page
↑ Liu, J et al. (2006) The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J. Mol. Biol. 360 133-44 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Rubinfeld, B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270 5549-55 PubMed GONUTS page
↑ ^9.0 ^9.1 Rubinfeld, B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-6 PubMed GONUTS page
↑ Tanaka, S et al. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc. Natl. Acad. Sci. U.S.A. 95 10164-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Takizawa, S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 11 453-64 PubMed GONUTS page
↑ ^12.0 ^12.1 Breitman, M et al. (2008) The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim. Biophys. Acta 1783 1792-802 PubMed GONUTS page
↑ ^13.0 ^13.1 Hart, MJ et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8 573-81 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Kaplan, KB et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3 429-32 PubMed GONUTS page
↑ Honnappa, S et al. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138 366-76 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Baeg, GH et al. (1995) The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J. 14 5618-25 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Zaoui, K et al. (2010) ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl. Acad. Sci. U.S.A. 107 18517-22 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Sagara, M et al. (2009) Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Oncogene 28 1357-65 PubMed GONUTS page
↑ Homma, MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc. Natl. Acad. Sci. U.S.A. 99 5959-64 PubMed GONUTS page
↑ ^20.0 ^20.1 Zumbrunn, J et al. (2001) Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr. Biol. 11 44-9 PubMed GONUTS page
↑ Ryo, A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 793-801 PubMed GONUTS page
↑ Askham, JM et al. (2000) Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 19 1950-8 PubMed GONUTS page
↑ Rubinfeld, B et al. (1993) Association of the APC gene product with beta-catenin. Science 262 1731-4 PubMed GONUTS page
↑ Jaiswal, AS et al. (2004) N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol. Cancer 3 3 PubMed GONUTS page
↑ ^25.0 ^25.1 Neufeld, KL et al. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc. Natl. Acad. Sci. U.S.A. 97 12085-90 PubMed GONUTS page
↑ ^26.0 ^26.1 Fagman, H et al. (2003) Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. Oncogene 22 6013-22 PubMed GONUTS page
↑ ^27.00 ^27.01 ^27.02 ^27.03 ^27.04 ^27.05 ^27.06 ^27.07 ^27.08 ^27.09 ^27.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Topol, L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162 899-908 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Dikovskaya, D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J. Cell Biol. 176 183-95 PubMed GONUTS page
↑ ^30.0 ^30.1 Ohshima, R et al. (2007) Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells 12 1339-45 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Kroboth, K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol. Biol. Cell 18 910-8 PubMed GONUTS page
↑ ^32.0 ^32.1 Anderson, CB et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc. Natl. Acad. Sci. U.S.A. 99 8683-8 PubMed GONUTS page
↑ Abal, M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132 2448-58 PubMed GONUTS page
↑ Roberts, DM et al. (2011) Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol. Biol. Cell 22 1845-63 PubMed GONUTS page
↑ Dikovskaya, D et al. (2012) The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. PLoS ONE 7 e38102 PubMed GONUTS page

[PMID:26948948-1] Liu, Z et al. (2016) Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Mol. Cell. Endocrinol. 427 57-64 PubMed GONUTS page

[PMID:7806582-2] 2.0 ^2.1 ^2.2 Hülsken, J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 2061-9 PubMed GONUTS page

[PMID:16344550-3] Yang, CK et al. (2006) Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J. Biol. Chem. 281 3389-97 PubMed GONUTS page

[PMID:28057765-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gao, FJ et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol. Biol. Cell 28 587-599 PubMed GONUTS page

[PMID:16753179-5] Liu, J et al. (2006) The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J. Mol. Biol. 360 133-44 PubMed GONUTS page

[PMID:24115276-6] Berwick, DC & Harvey, K (2014) The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol 6 3-12 PubMed GONUTS page

[PMID:16188939-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page

[PMID:7890674-8] 8.0 ^8.1 ^8.2 Rubinfeld, B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270 5549-55 PubMed GONUTS page

[PMID:8638126-9] 9.0 ^9.1 Rubinfeld, B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-6 PubMed GONUTS page

[PMID:9707618-10] Tanaka, S et al. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc. Natl. Acad. Sci. U.S.A. 95 10164-9 PubMed GONUTS page

[PMID:16611247-11] 11.0 ^11.1 Takizawa, S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 11 453-64 PubMed GONUTS page

[PMID:18502210-12] 12.0 ^12.1 Breitman, M et al. (2008) The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim. Biophys. Acta 1783 1792-802 PubMed GONUTS page

[PMID:9601641-13] 13.0 ^13.1 Hart, MJ et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8 573-81 PubMed GONUTS page

[PMID:11283619-14] 14.0 ^14.1 ^14.2 Kaplan, KB et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3 429-32 PubMed GONUTS page

[PMID:19632184-15] Honnappa, S et al. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138 366-76 PubMed GONUTS page

[PMID:8521819-16] 16.0 ^16.1 ^16.2 Baeg, GH et al. (1995) The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J. 14 5618-25 PubMed GONUTS page

[PMID:20937854-17] 17.0 ^17.1 ^17.2 Zaoui, K et al. (2010) ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl. Acad. Sci. U.S.A. 107 18517-22 PubMed GONUTS page

[PMID:19151759-18] 18.0 ^18.1 ^18.2 Sagara, M et al. (2009) Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Oncogene 28 1357-65 PubMed GONUTS page

[PMID:11972058-19] Homma, MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc. Natl. Acad. Sci. U.S.A. 99 5959-64 PubMed GONUTS page

[PMID:11166179-20] 20.0 ^20.1 Zumbrunn, J et al. (2001) Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr. Biol. 11 44-9 PubMed GONUTS page

[PMID:11533658-21] Ryo, A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 793-801 PubMed GONUTS page

[PMID:10773885-22] Askham, JM et al. (2000) Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 19 1950-8 PubMed GONUTS page

[PMID:8259518-23] Rubinfeld, B et al. (1993) Association of the APC gene product with beta-catenin. Science 262 1731-4 PubMed GONUTS page

[PMID:14728717-24] Jaiswal, AS et al. (2004) N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol. Cancer 3 3 PubMed GONUTS page

[PMID:11035805-25] 25.0 ^25.1 Neufeld, KL et al. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc. Natl. Acad. Sci. U.S.A. 97 12085-90 PubMed GONUTS page

[PMID:12955080-26] 26.0 ^26.1 Fagman, H et al. (2003) Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. Oncogene 22 6013-22 PubMed GONUTS page

[PMID:21873635-27] 27.00 ^27.01 ^27.02 ^27.03 ^27.04 ^27.05 ^27.06 ^27.07 ^27.08 ^27.09 ^27.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12952940-28] 28.0 ^28.1 ^28.2 ^28.3 Topol, L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162 899-908 PubMed GONUTS page

[PMID:17227893-29] 29.0 ^29.1 ^29.2 Dikovskaya, D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J. Cell Biol. 176 183-95 PubMed GONUTS page

[PMID:18076571-30] 30.0 ^30.1 Ohshima, R et al. (2007) Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells 12 1339-45 PubMed GONUTS page

[PMID:17192415-31] 31.0 ^31.1 ^31.2 Kroboth, K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol. Biol. Cell 18 910-8 PubMed GONUTS page

[PMID:12072559-32] 32.0 ^32.1 Anderson, CB et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc. Natl. Acad. Sci. U.S.A. 99 8683-8 PubMed GONUTS page

[PMID:17570218-33] Abal, M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132 2448-58 PubMed GONUTS page

[PMID:21471006-34] Roberts, DM et al. (2011) Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol. Biol. Cell 22 1845-63 PubMed GONUTS page

[PMID:22719865-35] Dikovskaya, D et al. (2012) The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. PLoS ONE 7 e38102 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

HUMAN:APC

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

k

l

m

n

o

p

r

u

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools