MOUSE:CTNB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ctnnb1 (synonyms: Catnb)
Protein Name(s)	Catenin beta-1 Beta-catenin
External Links
UniProt	Q02248
EMBL	M90364 AK035311 AK018515 BC006739 BC048153 BC053065
CCDS	CCDS23630.1
PIR	S35091
RefSeq	NP_001159374.1 NP_031640.1 XP_006511990.1
UniGene	Mm.291928
PDB	1DOW 1I7W 1I7X 1JPP 1M1E 1V18 2BCT 3BCT 3OUW 3OUX 4EV8 4EV9 4EVA 4EVP 4EVT 4ONS
PDBsum	1DOW 1I7W 1I7X 1JPP 1M1E 1V18 2BCT 3BCT 3OUW 3OUX 4EV8 4EV9 4EVA 4EVP 4EVT 4ONS
DisProt	DP00341
ProteinModelPortal	Q02248
SMR	Q02248
BioGrid	198512
DIP	DIP-31560N
IntAct	Q02248
MINT	MINT-103426
PhosphoSite	Q02248
MaxQB	Q02248
PaxDb	Q02248
PRIDE	Q02248
Ensembl	ENSMUST00000007130 ENSMUST00000178812
GeneID	12387
KEGG	mmu:12387
UCSC	uc009scu.2
CTD	1499
MGI	MGI:88276
eggNOG	NOG297695
GeneTree	ENSGT00730000110821
HOGENOM	HOG000230958
HOVERGEN	HBG000919
InParanoid	Q02248
KO	K02105
OMA	MRAFQDT
OrthoDB	EOG7X9G6B
PhylomeDB	Q02248
TreeFam	TF317997
Reactome	REACT_203336 REACT_207044 REACT_212869 REACT_216539 REACT_216784 REACT_218396 REACT_219771 REACT_221970 REACT_223626 REACT_230395 REACT_234076 REACT_248000 REACT_258576 REACT_258600 REACT_259776 REACT_260752 REACT_261276 REACT_261840
ChiTaRS	Ctnnb1
EvolutionaryTrace	Q02248
NextBio	281106
PMAP-CutDB	Q02248
PRO	PR:Q02248
Proteomes	UP000000589
Bgee	Q02248
CleanEx	MM_CTNNB1
ExpressionAtlas	Q02248
Genevestigator	Q02248
GO	GO:0005912 GO:0043296 GO:0045177 GO:0016323 GO:0030877 GO:0070369 GO:0016342 GO:0071664 GO:0005938 GO:0030054 GO:0071944 GO:0031253 GO:0005913 GO:0005911 GO:0005813 GO:0005737 GO:0009898 GO:0005829 GO:0043198 GO:0030057 GO:0070062 GO:0005916 GO:0014704 GO:0030027 GO:0016328 GO:0016020 GO:0031528 GO:0005634 GO:0048471 GO:0005886 GO:0032993 GO:0034750 GO:0000922 GO:0045202 GO:0005923 GO:0005667 GO:0030018 GO:0005915 GO:0045294 GO:0045296 GO:0003682 GO:0003677 GO:0003690 GO:0035257 GO:0019901 GO:0019903 GO:0070491 GO:0003700 GO:0005198 GO:0003713 GO:0008134 GO:0044212 GO:0034333 GO:0034332 GO:0009948 GO:0045453 GO:0001658 GO:0060070 GO:0044336 GO:0061324 GO:0044334 GO:0060038 GO:0060947 GO:0007155 GO:0030154 GO:0001709 GO:0001708 GO:0048469 GO:0000904 GO:0008283 GO:0007160 GO:0009987 GO:0034613 GO:0071363 GO:0071681 GO:1990314 GO:0071260 GO:0071407 GO:0022009 GO:0060982 GO:0007016 GO:0009950 GO:0009953 GO:0007398 GO:0000578 GO:0042733 GO:0048617 GO:0035115 GO:0035050 GO:0035116 GO:0036023 GO:0001706 GO:0001711 GO:0061154 GO:0060983 GO:0060742 GO:0060441 GO:0030900 GO:0061198 GO:0001702 GO:0035112 GO:0007403 GO:0022405 GO:0031069 GO:0060789 GO:0007507 GO:0030097 GO:0030902 GO:0001701 GO:0001822 GO:0021819 GO:0002089 GO:0060173 GO:0001889 GO:0060479 GO:0030324 GO:0060492 GO:0060484 GO:0030539 GO:0060916 GO:0003337 GO:0060485 GO:0072132 GO:0003338 GO:0007494 GO:0016331 GO:0045445 GO:2001234 GO:0045596 GO:0008285 GO:0032331 GO:0003136 GO:0045976 GO:1901215 GO:0048715 GO:0045671 GO:0033234 GO:0000122 GO:0045892 GO:0072079 GO:0001840 GO:0001764 GO:0042475 GO:0048599 GO:0048513 GO:0030316 GO:0060066 GO:0031016 GO:0001569 GO:0043065 GO:0061047 GO:0008284 GO:2000017 GO:0045603 GO:0030858 GO:0060769 GO:0010718 GO:0045743 GO:0010628 GO:0010909 GO:0043123 GO:0043410 GO:0002053 GO:0002052 GO:0045669 GO:0051973 GO:0045944 GO:0045893 GO:0051291 GO:0034394 GO:0009954 GO:0042981 GO:0090279 GO:0045595 GO:0042127 GO:0030997 GO:0070602 GO:0030856 GO:0010468 GO:0031641 GO:0072182 GO:0045667 GO:0045670 GO:2000008 GO:0003266 GO:0048660 GO:0042129 GO:0006357 GO:0006355 GO:0072053 GO:0072054 GO:0072001 GO:0072033 GO:0046686 GO:0034097 GO:0042493 GO:0032355 GO:0043627 GO:0014010 GO:0016337 GO:0001501 GO:0043588 GO:0051145 GO:0061549 GO:0050808 GO:0007268 GO:0048489 GO:0030217 GO:0033077 GO:0048538 GO:0060440 GO:0060439 GO:0006351 GO:0001944 GO:0001570 GO:0003223 GO:0016055
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000225 IPR013284
Pfam	PF00514
PRINTS	PR01869
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:23460868^[1]	ECO:0000315			P		Figure 2	complete CACAO 6888
part_of	GO:0005911	cell-cell junction	PMID:24338362^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000179	positive regulation of neural precursor cell proliferation	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:25232112^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1990138	neuron projection extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	PMID:11121423^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q24298	F		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	PMID:11121423^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09803	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:11121423^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q24298	C		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:11121423^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q24298	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:11121423^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P09803	C		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:11121423^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09803	F		Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0060070,GO:1904948	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25979161^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:25961718^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:1904639)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20371816^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P27782	P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000020866) occurs_in:(UBERON:0004703)	Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	PMID:20371816^[8]	ECO:0000305	curator inference used in manual assertion	GO:0003682,GO:0045944	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20371816^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSMUSG00000020866) occurs_in:(UBERON:0004703)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20371816^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540) part_of:(UBERON:0004703)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:20371816^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0004703)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:20371816^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:25009587^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0000700) occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
involved_in	GO:1904796	regulation of core promoter binding	PMID:22723415^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08775)	Seeded From UniProt	complete
involved_in	GO:0051569	regulation of histone H3-K4 methylation	PMID:22723415^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(UniProtKB:Q91X20)	Seeded From UniProt	complete
involved_in	GO:1904499	regulation of chromatin-mediated maintenance of transcription	PMID:22723415^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(UniProtKB:Q91X20)	Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:22899650^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904793	regulation of euchromatin binding	PMID:22723415^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q91X20)\|has_regulation_target:(UniProtKB:E9PYH6)	Seeded From UniProt	complete
involved_in	GO:1904499	regulation of chromatin-mediated maintenance of transcription	PMID:22723415^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(UniProtKB:E9PYH6)	Seeded From UniProt	complete
involved_in	GO:1990403	embryonic brain development	PMID:11262227^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990791	dorsal root ganglion development	PMID:11262227^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:0061550	cranial ganglion development	PMID:11262227^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:11262227^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:1904888	cranial skeletal system development	PMID:11262227^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	PMID:11262227^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:1904501	positive regulation of chromatin-mediated maintenance of transcription	PMID:22723415^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(SO:0000170) occurs_in:(CL:0002322) occurs_in:(GO:0000790)	Seeded From UniProt	complete
part_of	GO:0016600	flotillin complex	PMID:24046456^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000144	positive regulation of DNA-templated transcription, initiation	PMID:22723415^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22645310^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22645310^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:22645310^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QUR7	F	part_of:(GO:0030182)	Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	PMID:21752258^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:2000097)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:15905404^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9WVH3)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:22899650^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5S006	F	occurs_in:(GO:0005737) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	PMID:19122665^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003307)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:19122665^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q62226) occurs_in:(UBERON:0003079) part_of:(GO:0071542)	Seeded From UniProt	complete
involved_in	GO:0048096	chromatin-mediated maintenance of transcription	PMID:22723415^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(SO:0000170) occurs_in:(CL:0002322) occurs_in:(GO:0000790)	Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	PMID:22723415^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002250) occurs_in:(GO:0005634) occurs_at:(SO:0000170) has_regulation_target:(UniProtKB:P08775)\|occurs_in(GO:0005634) occurs_in:(CL:0000047) occurs_at:(SO:0000170) has_regulation_target:(UniProtKB:P08775)\|occurs_in(CL:0002322) occurs_in:(GO:0005634) occurs_at:(SO:0000170) has_regulation_target:(UniProtKB:P08775)	Seeded From UniProt	complete
enables	GO:1990226	histone methyltransferase binding	PMID:22723415^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F	occurs_in:(GO:0005634) occurs_in:(CL:0002322) has_direct_input:(UniProtKB:Q9UBL3)	Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:22723415^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:22723415^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)\|part_of:(CL:0002250)\|part_of:(CL:0000047)	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:22723415^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22723415^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000021611) occurs_in:(CL:0002322)	Seeded From UniProt	complete
enables	GO:1990226	histone methyltransferase binding	PMID:22723415^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F	occurs_in:(GO:0005634) occurs_in:(CL:0002322) has_direct_input:(UniProtKB:E9PYH6)	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:22723415^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:22723415^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60793	F	occurs_in:(GO:0005634) occurs_in:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:23460868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045976	negative regulation of mitotic cell cycle, embryonic	PMID:21325504^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	PMID:21325504^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061549	sympathetic ganglion development	PMID:21325504^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051884	regulation of timing of anagen	PMID:24681597^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24681597^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24681597^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:24681597^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:21393547^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q54MH2	F		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	PMID:9488439^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070602	regulation of centromeric sister chromatid cohesion	PMID:20300119^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	PMID:12464179^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036023	embryonic skeletal limb joint morphogenesis	PMID:21262216^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q91ZD1	P		Seeded From UniProt	complete
part_of	GO:0034750	Scrib-APC-beta-catenin complex	PMID:16611247^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:20300119^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23856522^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0090279	regulation of calcium ion import	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0072182	regulation of nephron tubule epithelial cell differentiation	PMID:19112489^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:17331723^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0048660	regulation of smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19112489^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12949260^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:14687547^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51448	F		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0030997	regulation of centriole-centriole cohesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:16973135^[31]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14522	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
involved_in	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12949260^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098831	presynaptic active zone cytoplasmic component	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098831	presynaptic active zone cytoplasmic component	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:14622577^[33]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:14622577^[33]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:14622577^[33]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:14622577^[33]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:8909549^[32]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000117 MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00001979 ZFIN:ZDB-GENE-980526-362	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 MGI:MGI:96650 PANTHER:PTN001153077 RGD:620412 RGD:70487 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88276 PANTHER:PTN001153077 UniProtKB:P14923 UniProtKB:P35222 WB:WBGene00000238 WB:WBGene00001979	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:19056892^[35]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1914487)	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:16678101^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12464179^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:12235125^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12235125^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:23824574^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1202879	F	has_participant:(MGI:MGI:107543)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21512031^[39]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:98364)\|has_participant:(MGI:MGI:1096393)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21350016^[40]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1914639)\|has_participant:(MGI:MGI:2146182)\|has_participant:(MGI:MGI:1351327)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20159597^[41]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16105) has_participant:(MGI:MGI:107516)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19690384^[42]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19620969^[43]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19619491^[44]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1343498)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:17767158^[45]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16818445^[46]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:96533)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16678101^[36]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16898) has_participant:(MGI:MGI:97588)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16581771^[47]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:88613)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15907834^[48]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16728) occurs_in:(CL:0000082) has_participant:(MGI:MGI:88180)\|occurs_in(EMAPA:16728) occurs_in:(CL:0000082) has_participant:(MGI:MGI:97357)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15778706^[49]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:35777) occurs_in:(CL:0000510) has_participant:(MGI:MGI:94880)\|occurs_in(EMAPA:35777) occurs_in:(CL:0000510) has_participant:(MGI:MGI:99583)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15024079^[50]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	PMID:17537789^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003338	metanephros morphogenesis	PMID:19060336^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:18326)\|has_participant:(EMAPA:31414)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003266	regulation of secondary heart field cardioblast proliferation	PMID:19620969^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002089	lens morphogenesis in camera-type eye	PMID:16102745^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3045749	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:18533146^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	acts_on_population_of:(CL:0000514) occurs_in:(EMAPA:35195)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:21937711^[56]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1334448	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001944	vasculature development	PMID:19129494^[57]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16470)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001894	tissue homeostasis	PMID:18635608^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	has_participant:(EMAPA:18692)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001840	neural plate development	PMID:22102609^[59]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:17537789^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:21937711^[56]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1334448	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001711	endodermal cell fate commitment	PMID:12194849^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858007,MGI:MGI:2148567	P	occurs_in:(EMAPA:16250) results_in_commitment_to:(CL:0000223)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001709	cell fate determination	PMID:15708565^[61]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:2176173	P	occurs_in:(EMAPA:16910) results_in_determination_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001708	cell fate specification	PMID:15866163^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148591,MGI:MGI:2148594,MGI:MGI:2450929	P	results_in_specification_of:(CL:0000138)\|results_in_specification_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001706	endoderm formation	PMID:23824574^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:4418897	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001706	endoderm formation	PMID:12194849^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858007,MGI:MGI:2148567	P	results_in_formation_of:(EMAPA:16070)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:8582267^[63]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857678	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:19204372^[64]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096327	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:17537789^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:19154719^[65]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	occurs_in:(EMAPA:36520)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:12975353^[66]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:15866163^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148591,MGI:MGI:2148594,MGI:MGI:2450929	P	results_in_development_of:(EMAPA:35495)	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:22665494^[67]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:98506) has_input:(MGI:MGI:98506) has_input:(MGI:MGI:98506)	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:16678101^[36]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:109330)	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000904	cell morphogenesis involved in differentiation	PMID:16102745^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3045749	P	occurs_in:(EMAPA:16799) results_in_morphogenesis_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000578	embryonic axis specification	PMID:9230313^[68]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000209	protein polyubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16040629^[69]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1347476)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:20454446^[70]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98957	P	regulates_o_occurs_in:(EMAPA:17962) regulates_o_occurs_in:(CL:0000654)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:20454446^[70]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	regulates_o_occurs_in:(EMAPA:17962) regulates_o_occurs_in:(CL:0000654)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:15131783^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	regulates_o_occurs_in:(EMAPA:35784)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000017	positive regulation of determination of dorsal identity	PMID:18316368^[72]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990138	neuron projection extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904798	positive regulation of core promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	PMID:22956852^[73]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135607	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	PMID:16102745^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3045749	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090279	regulation of calcium ion import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072079	nephron tubule formation	PMID:17537789^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072054	renal outer medulla development	PMID:19060336^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:18326)\|results_in_development_of:(EMAPA:31414)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072053	renal inner medulla development	PMID:19060336^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:18326)\|results_in_development_of:(EMAPA:31414)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072033	renal vesicle formation	PMID:17537789^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070602	regulation of centromeric sister chromatid cohesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061198	fungiform papilla formation	PMID:17128274^[74]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_formation_of:(EMAPA:35850)\|results_in_formation_of:(EMAPA:18272)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061154	endothelial tube morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061047	positive regulation of branching involved in lung morphogenesis	PMID:18533146^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	regulates_o_occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060916	mesenchymal cell proliferation involved in lung development	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060916	mesenchymal cell proliferation involved in lung development	PMID:17128274^[74]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	occurs_in:(EMAPA:16728) acts_on_population_of:(CL:0000514)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060789	hair follicle placode formation	PMID:19619491^[44]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1195272	P	results_in_formation_of:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060789	hair follicle placode formation	PMID:11371349^[75]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2148596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	PMID:12813461^[76]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	regulates_o_occurs_in:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060742	epithelial cell differentiation involved in prostate gland development	PMID:12813461^[76]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	occurs_in:(EMAPA:32290) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060492	lung induction	PMID:19805295^[77]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060492	lung induction	PMID:19686689^[78]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	has_participant:(EMAPA:16548)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060484	lung-associated mesenchyme development	PMID:18533146^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060479	lung cell differentiation	PMID:19805295^[77]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148569	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060440	trachea formation	PMID:19805295^[77]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148569	P	results_in_formation_of:(EMAPA:16737)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060439	trachea morphogenesis	PMID:18692041^[79]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060439	trachea morphogenesis	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060173	limb development	PMID:12569130^[80]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	results_in_development_of:(EMAPA:17412)\|results_in_development_of:(EMAPA:17458)	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:15314168^[81]	ECO:0000314	direct assay evidence used in manual assertion		P	positively_regulates:(GO:0003674) positively_regulates:(GO:0006366)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:20454446^[70]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98957	P	occurs_in:(EMAPA:17962) occurs_in:(CL:0000654)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19686689^[78]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261834 MGI:MGI:98954	P	occurs_in:(EMAPA:16548)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16818445^[46]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2446084	P	occurs_in:(EMAPA:18468) occurs_in:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16678101^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109330	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19690384^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3577106	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19619491^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17524) occurs_in:(CL:0000362)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19060336^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:18326) occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15781477^[82]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:12717450^[83]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:12464179^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:12235125^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060066	oviduct development	PMID:17532316^[84]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3042214	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051145	smooth muscle cell differentiation	PMID:19690384^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3577106	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:14622577^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048715	negative regulation of oligodendrocyte differentiation	PMID:19503085^[85]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	regulates_o_occurs_in:(EMAPA:16895) regulates_o_results_in_acquisition_of_features_of:(CL:0000128)\|regulates_o_occurs_in(EMAPA:17577) regulates_o_results_in_acquisition_of_features_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048660	regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048617	embryonic foregut morphogenesis	PMID:18692041^[79]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	results_in_morphogenesis_of:(EMAPA:16553)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048599	oocyte development	PMID:20454446^[70]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98957	P	occurs_in:(EMAPA:17962) results_in_development_of:(CL:0000654)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:16025118^[86]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	results_in_development_of:(EMAPA:18768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048513	animal organ development	PMID:18635608^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048489	synaptic vesicle transport	PMID:14622577^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:15576404^[87]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3044412	P	results_in_maturation_of:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:17706960^[88]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8853988^[89]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15314168^[81]	ECO:0000314	direct assay evidence used in manual assertion		P	positively_regulates:(GO:0003674) positively_regulates:(GO:0006366)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16678101^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109330	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15778706^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1202879	P	has_regulation_target:(MGI:MGI:94880)\|has_regulation_target:(MGI:MGI:99583)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15729346^[90]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104554 MGI:MGI:97487 MGI:MGI:98358	P	has_regulation_target:(MGI:MGI:102563)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15024079^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:101895)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21750544^[91]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1860483)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20627076^[92]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1859388)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20159597^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:107516)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19620969^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15907834^[48]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16728) regulates_o_occurs_in:(CL:0000082) has_regulation_target:(MGI:MGI:88180)\|regulates_o_occurs_in(EMAPA:16728) regulates_o_occurs_in:(CL:0000082) has_regulation_target:(MGI:MGI:97357)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19690384^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3577106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17767158^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15866163^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	regulates_o_occurs_in:(EMAPA:17501) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:98504)\|regulates_o_occurs_in(EMAPA:17501) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:96770)\|regulates_o_occurs_in(EMAPA:17426) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:98504)\|regulates_o_occurs_in(EMAPA:17426) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:96770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19056892^[35]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1914487)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16936075^[93]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12551949^[94]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10631168^[95]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15866163^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P	regulates_o_occurs_in:(EMAPA:17501) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:98371)\|regulates_o_occurs_in(EMAPA:17501) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:99829)\|regulates_o_occurs_in(EMAPA:17426) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:98371)\|regulates_o_occurs_in(EMAPA:17426) regulates_o_occurs_in:(CL:0000134) has_regulation_target:(MGI:MGI:99829)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12551949^[94]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	PMID:18533146^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	regulates_o_occurs_in:(EMAPA:16728) regulates_o_occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045671	negative regulation of osteoclast differentiation	PMID:15866165^[96]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3041864	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045670	regulation of osteoclast differentiation	PMID:15802266^[97]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	occurs_in:(EMAPA:19143) regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:15866163^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148591,MGI:MGI:2148594,MGI:MGI:2450929	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045667	regulation of osteoblast differentiation	PMID:15802266^[97]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	occurs_in:(EMAPA:19143) regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045667	regulation of osteoblast differentiation	PMID:15576404^[87]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3044412	P	occurs_in:(EMAPA:17213) regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045603	positive regulation of endothelial cell differentiation	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045596	negative regulation of cell differentiation	PMID:16102745^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3045749	P	occurs_in:(EMAPA:16805) regulates_o_results_in_acquisition_of_features_of:(CL:0000306)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045596	negative regulation of cell differentiation	PMID:15866163^[62]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148591,MGI:MGI:2148594,MGI:MGI:2450929	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045595	regulation of cell differentiation	PMID:12717450^[83]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045453	bone resorption	PMID:15866165^[96]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98504	P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045453	bone resorption	PMID:15866165^[96]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008,MGI:MGI:2148567,MGI:MGI:3041864	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:8853988^[89]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09803	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:15057752^[98]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09803	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:15023525^[99]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09803	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:10330403^[100]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A1A5I6	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	PMID:12432063^[101]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:23863479^[102]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:16249236^[103]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16530) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:15037549^[104]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17549) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:14758363^[105]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000066)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
involved_in	GO:0044093	positive regulation of molecular function	PMID:15314168^[81]	ECO:0000314	direct assay evidence used in manual assertion		P	positively_regulates:(GO:0003674) positively_regulates:(GO:0006366)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:19718027^[106]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P	results_in_development_of:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:16478791^[107]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0043296	apical junction complex	PMID:17666436^[108]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043296	apical junction complex	PMID:17130295^[109]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35735) part_of:(CL:0000635)	Seeded From UniProt	complete
part_of	GO:0043296	apical junction complex	PMID:16249236^[103]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16530) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:19619491^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17524)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
colocalizes_with	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:20043884^[110]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	regulates_o_occurs_in:(EMAPA:32618)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:20043884^[110]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1338938	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:20043884^[110]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:12923052^[111]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2158470	P	has_participant:(EMAPA:17458)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:15866165^[96]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	has_participant:(EMAPA:17918)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042129	regulation of T cell proliferation	PMID:14608382^[112]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2448686	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:18635608^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:17055474^[113]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:12235125^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035116	embryonic hindlimb morphogenesis	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035116	embryonic hindlimb morphogenesis	PMID:12923052^[111]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2158470	P	results_in_development_of:(EMAPA:17458)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035115	embryonic forelimb morphogenesis	PMID:15371327^[114]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:17710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035112	genitalia morphogenesis	PMID:18635608^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035050	embryonic heart tube development	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034613	cellular protein localization	PMID:16621792^[115]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034394	protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034333	adherens junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034332	adherens junction organization	PMID:19129494^[57]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034097	response to cytokine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033234	negative regulation of protein sumoylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:16025118^[86]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	occurs_in:(EMAPA:18768)	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:22083958^[116]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032355	response to estradiol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032331	negative regulation of chondrocyte differentiation	PMID:16818445^[46]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2446084	P	occurs_in:(EMAPA:18468) regulates_o_results_in_acquisition_of_features_of:(CL:0000138)	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031641	regulation of myelination	PMID:19515974^[117]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	regulates_o_has_participant:(EMAPA:17577)	Seeded From UniProt	complete
part_of	GO:0031528	microvillus membrane	PMID:16439479^[118]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16247) part_of:(CL:0000131)	Seeded From UniProt	complete
part_of	GO:0031253	cell projection membrane	PMID:16621792^[115]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:24309208^[119]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:5461544	P	results_in_morphogenesis_of:(EMAPA:18771)\|results_in_morphogenesis_of:(EMAPA:26720)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:11371349^[75]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2148596	P	has_participant:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031016	pancreas development	PMID:16192304^[120]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148569	P	results_in_development_of:(EMAPA:17503)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030997	regulation of centriole-centriole cohesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15708565^[61]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:2176173	P	results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:10318824^[121]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030858	positive regulation of epithelial cell differentiation	PMID:16040629^[69]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008,MGI:MGI:2445707,MGI:MGI:2679524	P	occurs_in:(EMAPA:32682) regulates_o_results_in_acquisition_of_features_of:(CL:0000082)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030856	regulation of epithelial cell differentiation	PMID:12813461^[76]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	occurs_in:(EMAPA:32290) regulates_o_results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030539	male genitalia development	PMID:19282366^[122]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P	results_in_development_of:(EMAPA:17969)	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:12885771^[123]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:15866165^[96]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	occurs_in:(EMAPA:17918) results_in_acquisition_of_features_of:(CL:0000092)\|occurs_in(EMAPA:35350) results_in_acquisition_of_features_of:(CL:0000092)\|occurs_in(EMAPA:35403) results_in_acquisition_of_features_of:(CL:0000092)\|occurs_in(EMAPA:32740) results_in_acquisition_of_features_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030217	T cell differentiation	PMID:14608382^[112]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2448686	P	occurs_in:(EMAPA:18767)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:16192304^[120]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148569	P	occurs_in:(EMAPA:17503) results_in_acquisition_of_features_of:(CL:0000622)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:15131783^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	occurs_in:(EMAPA:35784) results_in_acquisition_of_features_of:(CL:0000160)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030097	hemopoiesis	PMID:12717450^[83]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:14657280^[124]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:8821035^[125]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17701) part_of:(CL:0000188)\|part_of:(EMAPA:16105) part_of:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022405	hair cycle process	PMID:11371349^[75]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2148596	P	has_participant:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022009	central nervous system vasculogenesis	PMID:19023080^[126]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148569	P	results_in_formation_of:(EMAPA:16470)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021819	layer formation in cerebral cortex	PMID:20503375^[127]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3701617	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:8853988^[89]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016331	morphogenesis of embryonic epithelium	PMID:16102745^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3045749	P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:15645444^[128]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18941)	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:9950951^[129]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:20089884^[130]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002326)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:20016102^[131]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000589)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:17671182^[132]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35784) part_of:(CL:0000066)\|part_of:(EMAPA:35777) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:15226261^[133]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17503)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:14625387^[134]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:12885771^[123]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000307)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8821035^[125]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:22139371^[135]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17972)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21991325^[136]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16364283^[137]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15987773^[138]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32290) part_of:(CL:0000646)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:14657280^[124]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12611902^[139]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12432063^[101]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12055200^[140]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11731231^[141]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:17535849^[142]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014010	Schwann cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:19690384^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3577106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:18231602^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:22102609^[59]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009987	cellular process	PMID:12717450^[83]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:12885771^[123]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15708565^[61]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:2176173	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009950	dorsal/ventral axis specification	PMID:12923052^[111]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594,MGI:MGI:2158470	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009948	anterior/posterior axis specification	PMID:10662781^[143]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:19690384^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567,MGI:MGI:3577106	P	regulates_o_occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:15131783^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P	occurs_in:(EMAPA:32683)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16678101^[36]	ECO:0000353	physical interaction evidence used in manual assertion	MGI:MGI:109330	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:12464179^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007403	glial cell fate determination	PMID:17706960^[88]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007398	ectoderm development	PMID:8582267^[63]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857678	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:14622577^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	PMID:15131783^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148567	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:20043884^[110]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858008	P	has_regulation_target:(MGI:MGI:99604)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12464179^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12235125^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:17130295^[109]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35735) part_of:(CL:0000635)\|part_of:(CL:0000635) part_of:(CL:0000601)	Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	PMID:16481394^[144]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17339) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:17544522^[145]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:16892058^[146]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:16199027^[147]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:15775979^[148]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:15645444^[128]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17902) part_of:(CL:0000131)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:15292239^[149]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:15148305^[150]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:14657280^[124]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:11731229^[151]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16040) part_of:(CL:0000353)\|part_of:(EMAPA:16039) part_of:(CL:0000353)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:23824574^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16058)\|part_of:(EMAPA:16063)	Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:21991385^[152]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12695331^[153]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12203715^[154]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:9950951^[129]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:24191021^[155]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:21377456^[156]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000082)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:20089884^[130]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:18816447^[157]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17756) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:14597196^[158]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:12181493^[159]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000360)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:19151727^[160]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8853988^[89]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23266329^[161]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19966784^[162]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17577)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17596282^[163]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17503) part_of:(CL:0000622)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16962386^[164]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16858399^[165]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17547) part_of:(CL:0000047)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16740478^[166]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846) part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16418220^[167]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16046) part_of:(CL:1000274)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12040017^[168]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002325)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15673614^[169]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000056)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12055200^[140]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19213727^[170]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000062)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17128274^[74]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17185)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16489008^[171]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17528)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15574752^[172]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15525667^[173]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962) part_of:(CL:0000023)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14981260^[174]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12923052^[111]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16779) part_of:(CL:0000221)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12235125^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11731265^[175]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11731231^[141]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:16678101^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12861022^[176]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12464179^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25535395^[177]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23740243^[178]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23610556^[179]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:31873) part_of:(CL:0000351)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23266329^[161]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22665494^[67]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21991325^[136]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19850029^[180]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16530)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[181]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19497282^[182]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19213727^[170]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000062)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18978355^[183]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19318)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17615359^[184]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35777)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17596282^[163]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17503) part_of:(CL:0000622)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17560563^[185]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17128274^[74]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17185)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16989802^[186]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16936075^[93]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16858399^[165]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17547) part_of:(CL:0000047)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16678815^[187]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17760) part_of:(CL:0000150)\|part_of:(EMAPA:17761) part_of:(CL:0000134)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16489008^[171]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17528)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16439479^[118]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16247) part_of:(CL:0000131)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15866165^[96]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000062)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15866163^[62]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000138)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15778706^[49]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35777) part_of:(CL:0000510)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15574752^[172]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15371327^[114]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17416) part_of:(CL:0000134)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12923052^[111]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16779) part_of:(CL:0000221)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12885771^[123]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12874278^[188]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11872843^[189]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11731265^[175]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11731231^[141]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35222	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70487	C		Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
involved_in	GO:1990138	neuron projection extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0090279	regulation of calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
involved_in	GO:0071681	cellular response to indole-3-methanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0070602	regulation of centromeric sister chromatid cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0048660	regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
involved_in	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0030997	regulation of centriole-centriole cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
involved_in	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	F		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35222 ensembl:ENSP00000495360	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R2Q3 ensembl:ENSP00000495360	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013284	F		Seeded From UniProt	complete
involved_in	GO:1904173	regulation of histone demethylase activity (H3-K4 specific)	PMID:22723415^[10] PMID:22723415^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:Q91X20)	Seeded From UniProt	complete
involved_in	GO:0051569	regulation of histone H3-K4 methylation	PMID:22723415^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:E9PYH6)	Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	PMID:22723415^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072132	mesenchyme morphogenesis	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060983	epicardium-derived cardiac vascular smooth muscle cell differentiation	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060982	coronary artery morphogenesis	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060947	cardiac vascular smooth muscle cell differentiation	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060485	mesenchyme development	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060038	cardiac muscle cell proliferation	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003223	ventricular compact myocardium morphogenesis	PMID:20299672^[190]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-209096	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wong, J et al. (2013) β-catenin is essential for efficient in vitro premyogenic mesoderm formation but can be partially compensated by retinoic acid signalling. PLoS ONE 8 e57501 PubMed GONUTS page
↑ Phang, HQ et al. (2014) POPX2 phosphatase regulates the KIF3 kinesin motor complex. J. Cell. Sci. 127 727-39 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hsu, LC et al. (2015) Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 112 12199-204 PubMed GONUTS page
↑ Wang, SH et al. (2014) Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. J. Neurosci. 34 12745-61 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Huber, AH et al. (2001) The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. J. Biol. Chem. 276 12301-9 PubMed GONUTS page
↑ Jeong, BC et al. (2015) Transmembrane protein 64 reciprocally regulates osteoblast and adipocyte differentiation by modulating Wnt/β-catenin signaling. Bone 78 165-73 PubMed GONUTS page
↑ Campagnolo, P et al. (2015) Resveratrol-Induced Vascular Progenitor Differentiation towards Endothelial Lineage via MiR-21/Akt/β-Catenin Is Protective in Vessel Graft Models. PLoS ONE 10 e0125122 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wisniewska, MB et al. (2010) LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J. Neurosci. 30 4957-69 PubMed GONUTS page
↑ Dai, TL et al. (2014) Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease. Exp Ther Med 8 384-390 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page
↑ ^11.0 ^11.1 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Brault, V et al. (2001) Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128 1253-64 PubMed GONUTS page
↑ Guillaume, E et al. (2013) Flotillin microdomains stabilize cadherins at cell-cell junctions. J. Cell. Sci. 126 5293-304 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Nakamura, K et al. (2012) Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin. Mol. Cell. Biol. 32 2966-78 PubMed GONUTS page
↑ L'episcopo, F et al. (2011) A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener 6 49 PubMed GONUTS page
↑ Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page
↑ ^17.0 ^17.1 Joksimovic, M et al. (2009) Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat. Neurosci. 12 125-31 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Armstrong, A et al. (2011) Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. J. Neurosci. 31 2371-81 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Rognoni, E et al. (2014) Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat. Med. 20 350-9 PubMed GONUTS page
↑ Dickinson, DJ et al. (2011) A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science 331 1336-9 PubMed GONUTS page
↑ Korinek, V et al. (1998) Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol. Cell. Biol. 18 1248-56 PubMed GONUTS page
↑ ^22.0 ^22.1 Hadjihannas, MV et al. (2010) Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep. 11 317-24 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Kioussi, C et al. (2002) Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111 673-85 PubMed GONUTS page
↑ Gao, Y et al. (2011) The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev. Biol. 352 83-91 PubMed GONUTS page
↑ Takizawa, S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 11 453-64 PubMed GONUTS page
↑ Ohtani, K et al. (2013) Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ. Res. 113 856-62 PubMed GONUTS page
↑ ^27.0 ^27.1 Grote, D et al. (2008) Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet. 4 e1000316 PubMed GONUTS page
↑ Ulloa, F et al. (2007) Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr. Biol. 17 545-50 PubMed GONUTS page
↑ ^29.0 ^29.1 Jordan, BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc. Natl. Acad. Sci. U.S.A. 100 10866-71 PubMed GONUTS page
↑ Gold, DA et al. (2003) RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron 40 1119-31 PubMed GONUTS page
↑ Besco, JA et al. (2006) Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res. 1116 50-7 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 ^32.4 ^32.5 ^32.6 ^32.7 Uchida, N et al. (1996) The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. J. Cell Biol. 135 767-79 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 Bamji, SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40 719-31 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 ^34.4 ^34.5 ^34.6 ^34.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^35.0 ^35.1 Miranda-Carboni, GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22 3121-34 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 ^36.4 ^36.5 ^36.6 Olson, LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125 593-605 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 ^37.3 ^37.4 ^37.5 Widlund, HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J. Cell Biol. 158 1079-87 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 Engert, S et al. (2013) Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development 140 3128-38 PubMed GONUTS page
↑ Heallen, T et al. (2011) Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332 458-61 PubMed GONUTS page
↑ Karner, CM et al. (2011) Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 138 1247-57 PubMed GONUTS page
↑ ^41.0 ^41.1 Tian, Y et al. (2010) Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev. Cell 18 275-87 PubMed GONUTS page
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↑ ^43.0 ^43.1 ^43.2 Kwon, C et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat. Cell Biol. 11 951-7 PubMed GONUTS page
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[PMID:15775979-148] Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page

[PMID:15292239-149] Conti, MA et al. (2004) Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J. Biol. Chem. 279 41263-6 PubMed GONUTS page

[PMID:15148305-150] Tanoue, T & Takeichi, M (2004) Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J. Cell Biol. 165 517-28 PubMed GONUTS page

[PMID:11731229-151] Pantaleon, M et al. (2001) FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech. Dev. 109 151-60 PubMed GONUTS page

[PMID:21991385-152] Oidovsambuu, O et al. (2011) Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia. PLoS ONE 6 e25908 PubMed GONUTS page

[PMID:12695331-153] Lallemand, D et al. (2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 17 1090-100 PubMed GONUTS page

[PMID:12203715-154] Sinn, HW et al. (2002) Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev. Dyn. 225 1-13 PubMed GONUTS page

[PMID:24191021-155] Rockich, BE et al. (2013) Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 110 E4456-64 PubMed GONUTS page

[PMID:21377456-156] Pyrgaki, C et al. (2011) Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev. Biol. 353 38-49 PubMed GONUTS page

[PMID:18816447-157] Walker, JL et al. (2008) Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev. Dyn. 237 3128-41 PubMed GONUTS page

[PMID:14597196-158] Ellis, T et al. (2003) Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis. Dev. Biol. 263 203-15 PubMed GONUTS page

[PMID:12181493-159] Narducci, MG et al. (2002) TCL1 participates in early embryonic development and is overexpressed in human seminomas. Proc. Natl. Acad. Sci. U.S.A. 99 11712-7 PubMed GONUTS page

[PMID:19151727-160] Kleaveland, B et al. (2009) Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat. Med. 15 169-76 PubMed GONUTS page

[PMID:23266329-161] 161.0 ^161.1 Bell, SM et al. (2013) Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev. Biol. 375 128-39 PubMed GONUTS page

[PMID:19966784-162] Merte, J et al. (2010) Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat. Cell Biol. 12 41-6; sup pp 1-8 PubMed GONUTS page

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[PMID:12040017-168] Shillingford, JM et al. (2002) Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol. Endocrinol. 16 1309-21 PubMed GONUTS page

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[PMID:19213727-170] 170.0 ^170.1 Friedman, MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J. Biol. Chem. 284 14117-25 PubMed GONUTS page

[PMID:16489008-171] 171.0 ^171.1 Adolphe, C et al. (2006) Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 66 2081-8 PubMed GONUTS page

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[PMID:12861022-176] Kennell, JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol. Cell. Biol. 23 5366-75 PubMed GONUTS page

[PMID:25535395-177] Li, W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc. Natl. Acad. Sci. U.S.A. 112 166-71 PubMed GONUTS page

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[PMID:23610556-179] Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page

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[PMID:19497282-182] Le Grand, F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4 535-47 PubMed GONUTS page

[PMID:18978355-183] Tsika, RW et al. (2008) Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. J. Biol. Chem. 283 36154-67 PubMed GONUTS page

[PMID:17615359-184] Rakoff-Nahoum, S & Medzhitov, R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317 124-7 PubMed GONUTS page

[PMID:17560563-185] Ramasamy, SK et al. (2007) Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev. Biol. 307 237-47 PubMed GONUTS page

[PMID:16989802-186] De Langhe, SP et al. (2006) Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev. Biol. 299 52-62 PubMed GONUTS page

[PMID:16678815-187] Boras-Granic, K et al. (2006) Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev. Biol. 295 219-31 PubMed GONUTS page

[PMID:12874278-188] Kanamori, M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J. Biol. Chem. 278 38758-64 PubMed GONUTS page

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