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PMID:15148305

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Citation

Tanoue, T and Takeichi, M (2004) Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J. Cell Biol. 165:517-28

Abstract

Fat cadherins form a distinct subfamily of the cadherin gene superfamily, and are featured by their unusually large extracellular domain. In this work, we investigated the function of a mammalian Fat cadherin. Fat1 was localized at filopodial tips, lamellipodial edges, and cell-cell boundaries, overlapping with dynamic actin structures. RNA interference-mediated knockdown of Fat1 resulted in disorganization of cell junction-associated F-actin and other actin fibers/cables, disturbance of cell-cell contacts, and also inhibition of cell polarity formation at wound margins. Furthermore, we identified Ena/vasodilator-stimulated phosphoproteins as a potential downstream effector of Fat1. These results suggest that Fat1 regulates actin cytoskeletal organization at cell peripheries, thereby modulating cell contacts and polarity.

Links

PubMed PMC2172355 Online version:10.1083/jcb.200403006

Keywords

Actin Cytoskeleton/metabolism; Actin Cytoskeleton/ultrastructure; Actins/metabolism; Animals; Binding Sites/genetics; Cadherins/genetics; Cadherins/metabolism; Cell Adhesion/genetics; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cell Line; Cell Polarity/genetics; Fetus; Humans; Intercellular Junctions/metabolism; Intercellular Junctions/ultrastructure; Mice; Protein Binding/genetics; Protein Structure, Tertiary/genetics; Pseudopodia/metabolism; Pseudopodia/ultrastructure; Wound Healing/genetics

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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