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PMID:15131783

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Citation

Ireland, H, Kemp, R, Houghton, C, Howard, L, Clarke, AR, Sansom, OJ and Winton, DJ (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology 126:1236-46

Abstract

A system for introducing specific gene mutations into the epithelia of the adult murine gastrointestinal tract by the transcriptional regulation of Cre recombinase is presented and applied to delete beta-catenin, a central mediator of Wnt signaling, within the small intestine (SI).

Links

PubMed

Keywords

Animals; Cell Differentiation/physiology; Cell Division/physiology; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/physiology; DNA Nucleotidyltransferases/genetics; Digestive System/metabolism; Enzyme Inhibitors/pharmacology; Gene Expression/physiology; Gene Silencing; Goblet Cells/cytology; Intestinal Mucosa/metabolism; Intestines/cytology; Mice; Mice, Mutant Strains; Mice, Transgenic; Microvilli/metabolism; Rats; Recombination, Genetic; Tissue Distribution; Trans-Activators/genetics; Trans-Activators/physiology; beta Catenin; beta-Galactosidase/metabolism; beta-Naphthoflavone/pharmacology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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